Impact of obesity on infertility in women.
Zeynep Ozcan Dag,Berna Dilbaz +1 more
TLDR
Overweight women have a higher incidence of menstrual dysfunction and anovulation, and are at a high risk for reproductive health, and weight loss has beneficial effects on the reproductive outcomes in patients.Abstract:
The prevalence of obesity and overweight are increasing and have become an epidemic worldwide. Obesity has detrimental influences on all systems, including reproductive health. The prevalence of obesity in infertile women is high, and it is well known that there is an association between obesity and infertility. The relationship between obesity and reproductive functions is still being explored. Overweight women have a higher incidence of menstrual dysfunction and anovulation. Overweight and obese women are at a high risk for reproductive health. The risk of subfecundity and infertility, conception rates, miscarriage rates, and pregnancy complications are increased in these women. They have poor reproductive outcomes in natural as well as assisted conception. These poor reproductive outcomes include assisted reproduction such as ovulation induction, in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), and ovum donation cycles. Weight loss has beneficial effects on the reproductive outcomes in these patients.read more
Citations
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A Narrative Review of Obesity and Its Associated Complications in Iranian Women
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Elucidation of the changes occurring at the proteome level in ovaries of high‐fat diet‐induced obese rats
Hayal Uzelli Şimşek,M. G. B. Albayrak,Murat Kasap,Turgay Şimşek,Gurler Akpinar,Sertac Ata Guler,N. Zafer Canturk +6 more
TL;DR: The results demonstrated that the mechanisms related to energy production in the ovary tissue were particularly affected by the high‐fat diet.
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Oxidized low-density lipoprotein suppresses mouse granulosa cell differentiation through disruption of the hypoxia-inducible factor 1 pathway.
TL;DR: In this paper, the effect of oxLDL on the HIF1 pathway was investigated and it was found that exposure to oxLDl diminished the expression of HIF 1α and its target genes and suppressed the differentiation of mouse luteinized granulosa cells following induction by human Chorionic gonadotophin (hCG) under hypoxic conditions.
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Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment.
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