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Open AccessJournal ArticleDOI

Impact of obesity on infertility in women.

TLDR
Overweight women have a higher incidence of menstrual dysfunction and anovulation, and are at a high risk for reproductive health, and weight loss has beneficial effects on the reproductive outcomes in patients.
Abstract
The prevalence of obesity and overweight are increasing and have become an epidemic worldwide. Obesity has detrimental influences on all systems, including reproductive health. The prevalence of obesity in infertile women is high, and it is well known that there is an association between obesity and infertility. The relationship between obesity and reproductive functions is still being explored. Overweight women have a higher incidence of menstrual dysfunction and anovulation. Overweight and obese women are at a high risk for reproductive health. The risk of subfecundity and infertility, conception rates, miscarriage rates, and pregnancy complications are increased in these women. They have poor reproductive outcomes in natural as well as assisted conception. These poor reproductive outcomes include assisted reproduction such as ovulation induction, in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), and ovum donation cycles. Weight loss has beneficial effects on the reproductive outcomes in these patients.

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Citations
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Journal ArticleDOI

Computational and artificial neural network based study of functional SNPs of human LEPR protein associated with reproductive function.

TL;DR: This first comprehensive computational analysis of LEPR gene mutation has identified and analyzed the functional consequence and structural significance of the SNPs in LEPR using recently developed several computational algorithms and developed backpropagation algorithm to forestall the deleterious nature of SNP.
Journal ArticleDOI

Racial/ethnic disparities in infertility treatment utilization in the US, 2011–2019

TL;DR: The report of increased assisted reproductive technology (ART) utilization rates, and marked racial/ethnic differences in ART utilization highlight the importance of expanding knowledge of inequities that continue to impact marginalized groups, a critical step for informing actionable strategy formulations to address these inequities.

Ethno-Gynaeacological Knowledge and Preliminary Phytochemical Screenings of Medicinal Plants used in Lagos State, Nigeria

TL;DR: The prevalence of gynaeacological disorders worldwide has given rise to increased female infertility, morbidity and mortality (Ikechebelu, 2005), and physical factors such as age, stress, poor diet, lack of exercise, overweight, underweight and obesity can lead to abnormal functioning of the female reproductive system.
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Higher preconceptional maternal body mass index is associated with faster early preimplantation embryonic development: the Rotterdam periconception cohort.

TL;DR: In this paper, the impact of maternal BMI on embryo quality and morphokinetic parameters of pre-implantation embryos and predicted implantation potential was investigated and associations with clinical IVF outcomes were investigated.
Journal ArticleDOI

Trajectories and determinants of weight gain in two cohorts of young adult women born 16 years apart.

TL;DR: In this article, the authors compared baseline weights and weight gain trajectories; sociodemographic, behavioural and health characteristics driving weight gain; and estimated average weight in 20 years' time, in two cohorts of young women.
References
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Journal ArticleDOI

The hormone resistin links obesity to diabetes

TL;DR: It is shown that adipocytes secrete a unique signalling molecule, which is named resistin (for resistance to insulin), which circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity.
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Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

TL;DR: The pathophysiology of adiponectin and adiponECTin receptors in insulin resistance, diabetes, and the metabolic syndrome is described and potential versatile therapeutic targets to combat obesity-linked diseases characterized by insulin resistance are described.
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Adiponectin and Adiponectin Receptors

TL;DR: It is shown that AdipoR1 and AdIPoR2 serve as receptors for globular and full-length adiponectin and mediate increased AMP-activated protein kinase, peroxisome proliferator-activated receptor-alpha ligand activities, and glucose uptake and fatty-acid oxidation by adiponECTin.
Journal ArticleDOI

Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment.

TL;DR: Weight loss should be considered as a first option for women who are infertile and overweight, and the cost savings of the programme were considerable.
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