Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice.
Zunji Shi,Zunji Shi,Hehua Lei,Gui Chen,Peihong Yuan,Zheng Cao,Hooi-Leng Ser,Xuehang Zhu,Fang Wu,Caixiang Liu,Manyuan Dong,Yuchen Song,Yangyang Guo,Chuan Chen,Kexin Hu,Yifan Zhu,Xin An Zeng,Jinlin Zhou,Yu-Jing Lu,Andrew D. Patterson,Limin Zhang +20 more
- Vol. 6, Iss: 1
TLDR
In this article, the authors identify a mechanism linking intestinal Akkermansia muciniphila and the aryl hydrocarbon receptor (AHR) to saccharin/sucralose-induced nonalcoholic fatty liver disease (NAFLD) in mice.Abstract:
Noncaloric artificial sweeteners (NAS) are extensively introduced into commonly consumed drinks and foods worldwide. However, data on the health effects of NAS consumption remain elusive. Saccharin and sucralose have been shown to pass through the human gastrointestinal tract without undergoing absorption and metabolism and directly encounter the gut microbiota community. Here, we aimed to identify a novel mechanism linking intestinal Akkermansia muciniphila and the aryl hydrocarbon receptor (AHR) to saccharin/sucralose-induced nonalcoholic fatty liver disease (NAFLD) in mice. Saccharin/sucralose consumption altered the gut microbial community structure, with significant depletion of A. muciniphila abundance in the cecal contents of mice, resulting in disruption of intestinal permeability and a high level of serum lipopolysaccharide, which likely contributed to systemic inflammation and caused NAFLD in mice. Saccharin/sucralose also markedly decreased microbiota-derived AHR ligands and colonic AHR expression, which are closely associated with many metabolic syndromes. Metformin or fructo-oligosaccharide supplementation significantly restored A. muciniphila and AHR ligands in sucralose-consuming mice, consequently ameliorating NAFLD.IMPORTANCE Our findings indicate that the gut-liver signaling axis contributes to saccharin/sucralose consumption-induced NAFLD. Supplementation with metformin or fructo-oligosaccharide is a potential therapeutic strategy for NAFLD treatment. In addition, we also developed a new nutritional strategy by using a natural sweetener (neohesperidin dihydrochalcone [NHDC]) as a substitute for NAS and free sugars.read more
Citations
More filters
Journal ArticleDOI
T Cell Subsets and Natural Killer Cells in the Pathogenesis of Nonalcoholic Fatty Liver Disease
Yoseph Asmelash Gebru,Haripriya Gupta,Hyeong Seop Kim,Jung A Eom,Goo Hyun Kwon,Eun-Ju Park,Jin-Ju Jeong,Sung-Min Won,Satya Priya Sharma,Raja Ganesan,Dong Joon Kim,Ki Tae Suk +11 more
TL;DR: In this article, the authors discussed the nature and pathophysiological roles of T cell subsets including γδ T cells, NKT cells, Mucosal-associated invariant T (MAIT) cells as well as NK cells in NAFLD.
Journal ArticleDOI
Gut Microbiota Manipulation to Mitigate the Detrimental Effects of Environmental Pollutants
TL;DR: The ecotoxicology and human health risks of environmental pollutants are creating global concern, especially in the context of the prevalent and severe contamination of environmental abiotic and biotic compartments as discussed by the authors.
Journal ArticleDOI
Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver
Jian Jin,Jian Jin,Banrida Wahlang,Monika Thapa,Kimberly Z. Head,Josiah E. Hardesty,Sudhir Srivastava,Sudhir Srivastava,Michael L. Merchant,Shesh N. Rai,Russell A. Prough,Matthew C. Cave +11 more
TL;DR: In this article, aryl hydrocarbon receptor (AHR) biology, metabolic phenotyping and liver proteomics were performed in mice following ligand-activation or whole-body genetic ablation of this receptor.
Journal ArticleDOI
Dose-Dependent Beneficial Effects of Tryptophan and Its Derived Metabolites on Akkermansia In Vitro: A Preliminary Prospective Study
TL;DR: In this article, the possible effects of tryptophan and its derived metabolites on Akkermansia muciniphila were preliminarily investigated, including growth, physiological function, and metabolism.
Journal ArticleDOI
Alteration of fecal microbiome and metabolome by mung bean coat improves diet-induced non-alcoholic fatty liver disease in mice
TL;DR: Zhang et al. as discussed by the authors investigated whether MBC, which is rich in dietary fiber and phytochemicals, can protect against HFD-induced hepatic steatosis in mice via targeting gut microbiota and its metabolites.
References
More filters
Journal ArticleDOI
New insights and therapeutic implication of gut microbiota in non-alcoholic fatty liver disease and its associated liver cancer.
TL;DR: Dysbiosis of the gut microbiota, commonly considered as perturbation of microbiota diversity and composition, has been associated with intestinal and extra-intestinal diseases, including non-alcoholic fatty liver disease ( NAFLD) and its associated hepatocellular carcinoma (NAFLD-HCC).
Journal ArticleDOI
Quantitative proteomics reveals systematic dysregulations of liver protein metabolism in sucralose-treated mice.
TL;DR: The first quantitative proteomics for mice liver proteome was demonstrated, proposed that enhanced inflammation may be triggered by ribosomal inactivation in sucralose treated mice liver, and revealed the systematic dysregulations of protein metabolism after Sucralose treatment.
Journal ArticleDOI
Core Fucosylation of Intestinal Epithelial Cells Protects Against Salmonella Typhi Infection via Up-Regulating the Biological Antagonism of Intestinal Microbiota.
Sijia Hao,Qingjie Fan,Yaqiang Bai,Hui Fang,Jiaorui Zhou,Tomohiko Fukuda,Jianguo Gu,Ming Li,Wenzhe Li +8 more
TL;DR: In vitro and in vivo studies demonstrated that Wnt/β-catenin signaling pathway mediated the elevation of IECs core fucosylation level upon infection of S. Typhi, and revealed that the I ECs coreFut8 plays an important role in protecting against S Typhi infection via up-regulating the biological antagonism of intestinal microbiota.
Related Papers (5)
Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome.
Jane M. Natividad,Allison Agus,Julien Planchais,Bruno Lamas,Bruno Lamas,Anne-Charlotte Jarry,Rebeca Martín,Marie-Laure Michel,Caroline Chong-Nguyen,Ronan Roussel,Ronan Roussel,Marjolène Straube,Sarah Jegou,Claire McQuitty,Maude Le Gall,Grégory Da Costa,Emmanuelle Lecornet,Chloé Michaudel,Morgane Modoux,Morgane Modoux,Jérémy Glodt,Chantal Bridonneau,Bruno Sovran,Louise Dupraz,Louise Dupraz,André Bado,Mathias L. Richard,Philippe Langella,Boris Hansel,Boris Hansel,Jean-Marie Launay,Ramnik J. Xavier,Henri Duboc,Harry Sokol,Harry Sokol,Harry Sokol +35 more
Dietary betaine prevents obesity through gut microbiota-drived microRNA-378a family.
Jingjing Du,Peiwen Zhang,Jiang Luo,Linyuan Shen,Shunhua Zhang,Hao Gu,Jin He,Linghui Wang,Xue Zhao,Mailing Gan,Liu Yang,Lili Niu,Ye Zhao,Qianzi Tang,Guoqing Tang,Dongmei Jiang,Yanzhi Jiang,Mingzhou Li,Anan Jiang,Long Jin,Jideng Ma,Surong Shuai,Lin Bai,Jinyong Wang,Bo Zeng,De Wu,Xuewei Li,Li Zhu +27 more