Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice.
Zunji Shi,Zunji Shi,Hehua Lei,Gui Chen,Peihong Yuan,Zheng Cao,Hooi-Leng Ser,Xuehang Zhu,Fang Wu,Caixiang Liu,Manyuan Dong,Yuchen Song,Yangyang Guo,Chuan Chen,Kexin Hu,Yifan Zhu,Xin An Zeng,Jinlin Zhou,Yu-Jing Lu,Andrew D. Patterson,Limin Zhang +20 more
- Vol. 6, Iss: 1
TLDR
In this article, the authors identify a mechanism linking intestinal Akkermansia muciniphila and the aryl hydrocarbon receptor (AHR) to saccharin/sucralose-induced nonalcoholic fatty liver disease (NAFLD) in mice.Abstract:
Noncaloric artificial sweeteners (NAS) are extensively introduced into commonly consumed drinks and foods worldwide. However, data on the health effects of NAS consumption remain elusive. Saccharin and sucralose have been shown to pass through the human gastrointestinal tract without undergoing absorption and metabolism and directly encounter the gut microbiota community. Here, we aimed to identify a novel mechanism linking intestinal Akkermansia muciniphila and the aryl hydrocarbon receptor (AHR) to saccharin/sucralose-induced nonalcoholic fatty liver disease (NAFLD) in mice. Saccharin/sucralose consumption altered the gut microbial community structure, with significant depletion of A. muciniphila abundance in the cecal contents of mice, resulting in disruption of intestinal permeability and a high level of serum lipopolysaccharide, which likely contributed to systemic inflammation and caused NAFLD in mice. Saccharin/sucralose also markedly decreased microbiota-derived AHR ligands and colonic AHR expression, which are closely associated with many metabolic syndromes. Metformin or fructo-oligosaccharide supplementation significantly restored A. muciniphila and AHR ligands in sucralose-consuming mice, consequently ameliorating NAFLD.IMPORTANCE Our findings indicate that the gut-liver signaling axis contributes to saccharin/sucralose consumption-induced NAFLD. Supplementation with metformin or fructo-oligosaccharide is a potential therapeutic strategy for NAFLD treatment. In addition, we also developed a new nutritional strategy by using a natural sweetener (neohesperidin dihydrochalcone [NHDC]) as a substitute for NAS and free sugars.read more
Citations
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Journal ArticleDOI
Dietary Isoquercetin Reduces Hepatic Cholesterol and Triglyceride in NAFLD Mice by Modulating Bile Acid Metabolism via Intestinal FXR-FGF15 Signaling.
Ce Zhang,Zunji Shi,Hehua Lei,Fang Wu,Chuan Chen,Zheng Cao,Yuchen Song,Cui Zhang,Jinlin Zhou,Yu-Jing Lu,Limin Zhang +10 more
TL;DR: In this paper , a combination of 16S rRNA gene sequencing, targeted quantification of bile acids (BAs), and biological assays was employed to investigate the beneficial effects of isoquercetin on NAFLD in mice.
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Perillartine protects against metabolic associated fatty liver in high-fat diet-induced obese mice.
Yang Xiao,Lianggui Xiao,Mingming Li,Songsong Liu,Yuwei Wang,Liang Huang,Siqi Liu,Tianyu Jiang,Li Zhou,Yixing Li +9 more
TL;DR: In this article , a natural product called perillartine derived from Perilla frutescens (L) was used to treat metabolic associated fatty liver disease (MAL) in mice.
Journal ArticleDOI
Swainsonine Induces Liver Inflammation in Mice via Disturbance of Gut Microbiota and Bile Acid Metabolism.
Keyi Fu,Xin Chen,Na Shou,Zilong Wang,X Yuan,Dapeng Wu,Qi Wang,Ya-Chih Cheng,Ning Ling,Zunji Shi +9 more
TL;DR: The authors showed that swainsonine significantly upregulated the levels of deoxycholic acid and taurine-β-muricholic acid in the serum and liver of mice due to the markedly increased genus Clostridium and decreased genus Lactobacillus in the gut.
Journal ArticleDOI
Function of Akkermansia muciniphila in type 2 diabetes and related diseases
TL;DR: A. muciniphila is considered the "next-generation probiotic" for alleviating metabolic disorders and the inflammatory response as discussed by the authors , which has been shown to improve metabolism, alleviating inflammation, enhancing intestinal barrier function, and maintaining microbiota homeostasis.
Journal ArticleDOI
Interplay of Lymphocytes with the Intestinal Microbiota in Children with Nonalcoholic Fatty Liver Disease
TL;DR: In this paper , the effect of lymphocytes on the gut microbiota of children with nonalcoholic fatty liver disease (NAFLD) was explored using 16S rRNA gene and metagenomic sequencing.
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Journal ArticleDOI
Alterations of the human gut microbiome in liver cirrhosis
Nan Qin,Fengling Yang,Ang Li,Edi Prifti,Yanfei Chen,Li Shao,Jing Guo,Jian Yao,Lingjiao Wu,Jiawei Zhou,Ni Shujun,Lin Liu,Nicolas Pons,Jean-Michel Batto,Sean Kennedy,Pierre Leonard,Chunhui Yuan,Wenchao Ding,Yuanting Chen,Xinjun Hu,Beiwen Zheng,Guirong Qian,Wei Xu,S. Dusko Ehrlich,Shu-Sen Zheng,Lanjuan Li +25 more
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Journal ArticleDOI
Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22
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TL;DR: A metabolic pathway whereby Trp metabolites from the microbiota balance mucosal reactivity in mice is described, whereby highly adaptive lactobacilli are expanded and produce an aryl hydrocarbon receptor (AhR) ligand-indole-3-aldehyde-that contributes to AhR-dependent Il22 transcription.
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