Journal ArticleDOI
Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease.
Oliver Wirths,Henning Breyhan,Andrea Marcello,Marie-Caroline Cotel,Wolfgang Brück,Thomas A. Bayer +5 more
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TLDR
Examination of expression levels of various inflammatory and oxidative stress markers in pre-symptomatic and diseased APP/PS1KI mice added further evidence to the assumption that inflammatory processes are tightly associated with axonal degeneration and neuron loss, as is evident in the APP/ PS1KI mouse model.About:
This article is published in Neurobiology of Aging.The article was published on 2010-05-01. It has received 123 citations till now. The article focuses on the topics: Neurodegeneration & Genetically modified mouse.read more
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Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice
Ehud Cohen,Johan Paulsson,Pablo Blinder,Tal Burstyn-Cohen,Deguo Du,Gabriela Estepa,Anthony Adame,Hang M. Pham,Martin Holzenberger,Jeffery W. Kelly,Eliezer Masliah,Andrew Dillin +11 more
TL;DR: It is found that delayed aging by IIS reduction protects the nematode C. elegans from toxicity associated with the aggregation of the Alzheimer's disease-linked human peptide, Aβ, and this indicates that the IGF signaling-regulated mechanism that protects from Aβ toxicity is conserved from worms to mammals.
Journal ArticleDOI
Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease
TL;DR: In this article, the dual roles of microglia in the pathogenesis of Alzheimer's disease (AD) were investigated and it was shown that microglias are involved in AD pathogenesis.
Journal ArticleDOI
Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease
Amanda L. Wright,Raphael Zinn,Raphael Zinn,Barbara Hohensinn,Barbara Hohensinn,Lyndsey M. Konen,Sarah B. Beynon,Richard P. Tan,Ian A. Clark,Andrea Abdipranoto,Bryce Vissel,Bryce Vissel +11 more
TL;DR: The possibility that plaque load may not be the best marker for early AD is raised and it is suggested that activated microglia could be a valuable marker to track disease progression.
Journal ArticleDOI
High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model.
Carl Julien,Cyntia Tremblay,Alix Phivilay,Line Berthiaume,Vincent Emond,Pierre Julien,Frédéric Calon +6 more
TL;DR: Low n-3:n-6 PUFA intake ratio increased insoluble tau regardless of total fat consumption, whereas high-fat diet incorporating a low n- 3: n-n- 6 PUFA ratio also increased soluble tau compared to controls.
Journal ArticleDOI
Contribution of systemic inflammation to chronic neurodegeneration.
TL;DR: The normal homeostatic role that microglia play in signalling about systemic infections and inflammation becomes maladaptive in the aged and diseased brain and this offers a route to therapeutic intervention.
References
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Journal ArticleDOI
Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
TL;DR: Development and application of REST is explained, the usefulness of relative expression in real-time PCR using REST is discussed and the mathematical model used is based on the PCR efficiencies and the mean crossing point deviation between the sample and control group.
Journal ArticleDOI
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
TL;DR: The detected large numbers of HLA-DR-positive reactive microglia (macrophages) in the substantia nigra of all cases studied with Parkinson's disease and parkinsonism and suggest a frequent coexistence of DAT- and Parkinson-type pathology in elderly patients.
Journal ArticleDOI
Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease.
Gorazd B. Stokin,Concepción Lillo,Tomás L. Falzone,Richard G. Brusch,Edward Rockenstein,Stephanie L. Mount,Rema Raman,Peter Davies,Eliezer Masliah,David S. Williams,Lawrence S.B. Goldstein +10 more
TL;DR: Reductions in microtubule-dependent transport may stimulate proteolytic processing of β-amyloid precursor protein, resulting in the development of senile plaques and Alzheimer's disease.
Journal ArticleDOI
Microglia Initiate Central Nervous System Innate and Adaptive Immune Responses through Multiple TLRs
Julie K. Olson,Stephen D. Miller +1 more
TL;DR: Mouse microglia express mRNA for all of the recently identified TLRs, TLR1–9, used for recognition of bacterial and viral molecular patterns, and appear to be a unique and important component of both the innate and adaptive immune response, providing the CNS with a means to rapidly and efficiently respond to a wide variety of pathogens.
Journal ArticleDOI
The pathogenesis of senile plaques
TL;DR: Control the local inflammatory microenvironment of SP may hold promise for slowing lesion pathogenesis, but it still remains a fundamental challenge to determine the mechanism of neurodegeneration that results in widespread neurofibrillary degeneration and eventual synaptic and neuronal loss.
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