Journal ArticleDOI
Integrins: a family of cell surface receptors.
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TLDR
This brief review of sequence data from embryogenesis, thrombosis, and lymphocyte help and killing is summarized and attempts to clarify the relationships among the members of this family of cell surface receptors.About:
This article is published in Cell.The article was published on 1987-02-27. It has received 4229 citations till now. The article focuses on the topics: Integrin & Cell adhesion.read more
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Talin, vinculin and DRP (utrophin) concentrations are increased at mdx myotendinous junctions following onset of necrosis.
TL;DR: Findings indicate that mdx mice may compensate in part for the absence of dystrophin by increased expression of other molecules that subsume dyStrophin's mechanical function.
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Distinct mechanisms of epithelial adhesion for candida albicans and candida tropicalis identification of the participating ligands and development of inhibitory peptides
TL;DR: Results indicate that the pathogenic yeasts C. albicans and C. tropicalis recognize distinct RGD ligands present at the surface of the epithelial cell and that these interactions can be differentially inhibited by defined RGD peptides containing appropriate flanking sequences.
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Expression of leucocyte adhesion molecules at the human blood-brain barrier (BBB).
TL;DR: In brain tumors and inflammatory brain lesions, an up‐regulation of endothelial ICAM1 and LFA3 expression is observed, whereas other adhesion molecules on endothelial cells remained unchanged.
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Mechanisms of Human Lymphocyte Migration and their Role in the Pathogenesis of Disease
TL;DR: Evidence indicating that adhesive interactions between recirculating lymphocytes and the wall of high endothelial venules (HEV) are thought to play a central role in the pathogenesis of chronic inflammatory diseases and non-Hodgkin's lymphomas is discussed.
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Mechanism of skin morphogenesis. I. Analyses with antibodies to adhesion molecules tenascin, N-CAM, and integrin.
Ting-Xin Jiang,Cheng-Ming Chuong +1 more
TL;DR: The results indicated that these adhesion molecules are independently regulated and each contributes in different phases during morphogenesis of skin appendages.
References
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Arg-Gly-Asp: a versatile cell recognition signal.
TL;DR: The RGD sequence as a basic unit of a widespread cellular recognition system is established and the same peptides also inhibit the attachment of fibroblasts to a number of other proteins, including vitronectin.
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Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage
TL;DR: The interaction of the purified CSAT antigen with these cytoskeletal components is investigated, and an interaction specifically between theCSAT antigen and talin is demonstrated.
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Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins.
TL;DR: Recognition of the molecular pathogenesis of this disorder has allowed rich insights into the role of cellular adherence reactions in inflammation and host defense.
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Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor
TL;DR: Affinity chromatography on wheat germ agglutinin-Sepharose showed that the 140 kd protein is a glycoprotein and, in combination with the fibronectin fragment chromatography, gave highly enriched preparations of the 140Kd protein.
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Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors
TL;DR: The results establish the existence of a family of adhesion receptors that recognize the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen.