Journal ArticleDOI
Integrins: a family of cell surface receptors.
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TLDR
This brief review of sequence data from embryogenesis, thrombosis, and lymphocyte help and killing is summarized and attempts to clarify the relationships among the members of this family of cell surface receptors.About:
This article is published in Cell.The article was published on 1987-02-27. It has received 4229 citations till now. The article focuses on the topics: Integrin & Cell adhesion.read more
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Identification of the major proteins that promote neuronal process outgrowth on Schwann cells in vitro.
TL;DR: It is shown that Schwann cells are the best substrate yet identified for promoting process growth in vitro by peripheral motor neurons and imply that neuronal growth cones use integrin-class extracellular matrix receptors and at least two CAMs--N-cadherin and L1/Ng-CAM-for growth on Schwan cells in vitro.
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The influence of the microenvironment on the malignant phenotype
TL;DR: This work uses selected examples to illustrate the influence of the microenvironment in the evolution of the malignant phenotype and discusses recent studies that suggest novel therapeutic interventions might be derived from focusing on microenvironment and tumor cells interactions.
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Occupation of the extracellular matrix receptor, integrin, is a control point for myogenic differentiation
A S Menko,David Boettiger +1 more
TL;DR: The data indicate that the interaction of integrin, present on the membrane of replicating myoblasts, with extracellular matrix on the substrate is essential to initiate the terminal stages of myogenic differentiation.
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Structure and mechanics of integrin-based cell adhesion.
TL;DR: Recent advances in the structural elucidation of integrins and integrin-binding cytoskeleton proteins are the subjects of this review.
References
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Arg-Gly-Asp: a versatile cell recognition signal.
TL;DR: The RGD sequence as a basic unit of a widespread cellular recognition system is established and the same peptides also inhibit the attachment of fibroblasts to a number of other proteins, including vitronectin.
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Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage
TL;DR: The interaction of the purified CSAT antigen with these cytoskeletal components is investigated, and an interaction specifically between theCSAT antigen and talin is demonstrated.
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Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins.
TL;DR: Recognition of the molecular pathogenesis of this disorder has allowed rich insights into the role of cellular adherence reactions in inflammation and host defense.
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Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor
TL;DR: Affinity chromatography on wheat germ agglutinin-Sepharose showed that the 140 kd protein is a glycoprotein and, in combination with the fibronectin fragment chromatography, gave highly enriched preparations of the 140Kd protein.
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Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors
TL;DR: The results establish the existence of a family of adhesion receptors that recognize the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen.