Journal ArticleDOI
Integrins: a family of cell surface receptors.
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TLDR
This brief review of sequence data from embryogenesis, thrombosis, and lymphocyte help and killing is summarized and attempts to clarify the relationships among the members of this family of cell surface receptors.About:
This article is published in Cell.The article was published on 1987-02-27. It has received 4229 citations till now. The article focuses on the topics: Integrin & Cell adhesion.read more
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Journal ArticleDOI
Control of intracellular pH and growth by fibronectin in capillary endothelial cells
TL;DR: It is concluded that FN and FGF exert their growth-modulating effects in part through activation of the Na+/H+ exchanger, although they appear to trigger this system via separate pathways.
Journal ArticleDOI
Matrix and the retinal pigment epithelium in proliferative retinal disease.
TL;DR: The development of PVR, and the resulting tractional distortion of the neuroretina, appears to be dependent on RPE-matrix interactions and the interactions present a number of potential therapeutic targets for the management of the disorder.
Journal ArticleDOI
Regeneration after acute tubular necrosis.
TL;DR: A 44 year-old woman took six mercuric bichloride tablets and entered the hospital with nausea and abdominal cramps three hours later and died on the 29th day after clearances of inulin, creatinine and PAH were infinitesimal on six occasions.
Journal ArticleDOI
Tenascin mediates cell attachment through an RGD-dependent receptor.
M A Bourdon,Erkki Ruoslahti +1 more
TL;DR: The results identify the tenascin receptor as a member of the fibronectin receptor family within the integrin superfamily of receptors, suggesting that cell adhesion and motility may be modulated at those sites whereTenascin is expressed in the extracellular matrix.
Reference EntryDOI
von Willebrand factor.
TL;DR: The von Willebrand factor is a multimeric plasma glycoprotein synthesized by endothelial cells and megakaryotes and it serves as both a carrier for factor VIII and as a mediator of initial platelet adhesion to the subendothelium.
References
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Journal ArticleDOI
Arg-Gly-Asp: a versatile cell recognition signal.
TL;DR: The RGD sequence as a basic unit of a widespread cellular recognition system is established and the same peptides also inhibit the attachment of fibroblasts to a number of other proteins, including vitronectin.
Journal ArticleDOI
Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage
TL;DR: The interaction of the purified CSAT antigen with these cytoskeletal components is investigated, and an interaction specifically between theCSAT antigen and talin is demonstrated.
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Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins.
TL;DR: Recognition of the molecular pathogenesis of this disorder has allowed rich insights into the role of cellular adherence reactions in inflammation and host defense.
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Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor
TL;DR: Affinity chromatography on wheat germ agglutinin-Sepharose showed that the 140 kd protein is a glycoprotein and, in combination with the fibronectin fragment chromatography, gave highly enriched preparations of the 140Kd protein.
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Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors
TL;DR: The results establish the existence of a family of adhesion receptors that recognize the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen.