Journal ArticleDOI
Integrins: a family of cell surface receptors.
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This brief review of sequence data from embryogenesis, thrombosis, and lymphocyte help and killing is summarized and attempts to clarify the relationships among the members of this family of cell surface receptors.About:
This article is published in Cell.The article was published on 1987-02-27. It has received 4229 citations till now. The article focuses on the topics: Integrin & Cell adhesion.read more
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Transforming growth factor beta enhances integrin expression and type IV collagenase secretion in human monocytes.
TL;DR: TGF-beta may play a pivotal role in the early phases of inflammation and repair through its ability to mediate monocyte adhesion, chemotaxis, and enzymatic digestion of extracellular matrix, whereas in chronic lesions, excess TGF- beta may contribute to persistent leukocyte accumulation.
Journal ArticleDOI
Muc-1, Integrin, and Osteopontin Expression During the Implantation Cascade in Sheep
Greg A. Johnson,Fuller W. Bazer,Laurie A. Jaeger,Hakhyun Ka,Jane E. Garlow,Christiane Pfarrer,Thomas E. Spencer,Robert C. Burghardt +7 more
TL;DR: A physiological framework is provided for the role of OPN, a potential mediator of implantation in sheep, as a bridge between integrin heterodimers expressed by Tr and uterine LE responsible for adhesion for initial conceptus attachment.
Journal Article
Generalizations regarding the process and phenomenon of osseointegration. Part II. In vitro studies.
TL;DR: Cell culture provides access to molecular and cellular information that fosters nanostructural engineering approaches to implant design and significant hypotheses to be tested in vivo, and offers unique insights into the process and phenomenon of osseointegration.
Journal ArticleDOI
Syndecan from embryonic tooth mesenchyme binds tenascin.
Markku Salmivirta,Klaus Elenius,Seppo Vainio,U Hofer,R Chiquet-Ehrismann,Irma Thesleff,Markku Jalkanen +6 more
TL;DR: Syndecan is a cell surface heparan sulfate-rich proteoglycan found on various epithelial cells but also in some embryonic mesenchymal tissues as discussed by the authors.
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Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis.
A Laffon,Rosario García-Vicuña,A. Humbría,Antonio Postigo,Angel L. Corbí,M O de Landázuri,Francisco Sánchez-Madrid +6 more
TL;DR: The results show that activated T cells selectively localize at sites of tissue injury in RA disease and provide evidence for the in vivo regulation of the expression and function of the VLA-4 integrin.
References
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Arg-Gly-Asp: a versatile cell recognition signal.
TL;DR: The RGD sequence as a basic unit of a widespread cellular recognition system is established and the same peptides also inhibit the attachment of fibroblasts to a number of other proteins, including vitronectin.
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Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage
TL;DR: The interaction of the purified CSAT antigen with these cytoskeletal components is investigated, and an interaction specifically between theCSAT antigen and talin is demonstrated.
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Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins.
TL;DR: Recognition of the molecular pathogenesis of this disorder has allowed rich insights into the role of cellular adherence reactions in inflammation and host defense.
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Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor
TL;DR: Affinity chromatography on wheat germ agglutinin-Sepharose showed that the 140 kd protein is a glycoprotein and, in combination with the fibronectin fragment chromatography, gave highly enriched preparations of the 140Kd protein.
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Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors
TL;DR: The results establish the existence of a family of adhesion receptors that recognize the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen.