Journal ArticleDOI
Integrins: a family of cell surface receptors.
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TLDR
This brief review of sequence data from embryogenesis, thrombosis, and lymphocyte help and killing is summarized and attempts to clarify the relationships among the members of this family of cell surface receptors.About:
This article is published in Cell.The article was published on 1987-02-27. It has received 4229 citations till now. The article focuses on the topics: Integrin & Cell adhesion.read more
Citations
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Alpha 2 beta 1 integrins from different cell types show different binding specificities.
TL;DR: Functional analysis using rechromatography of purified receptors on laminin and collagen-Sepharose showed that endothelial alpha 2 beta 1 was able to bind to lamin in, whereas its counterpart from platelets did not.
Journal ArticleDOI
Beta amyloid precursor protein mediates neuronal cell-cell and cell-surface adhesion.
TL;DR: The data suggest that the APP, which is expressed primarily on differentiated neuronal cells, may play a role in the mediation of both cell‐cell and cell‐substrate adhesion.
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Tamm-Horsfall protein--uromodulin (1950-1990).
Satish Kumar,Andrew V. Muchmore +1 more
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The role of the LFA-1/ICAM-1 interaction in human leukocyte homing and adhesion
S O Wawryk,J R Novotny,Ian P. Wicks,D. Wilkinson,D. Maher,E Salvaris,K. Welch,JV Fecondo,Andrew W. Boyd +8 more
TL;DR: The analysis of some of the mechanisms which mediate leukocyte binding to vascular endothehum and of the subsequent events within the tissues will be the major focus of this review.
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The major non-integrin laminin binding protein of macrophages is identical to carbohydrate binding protein 35 (Mac-2).
TL;DR: It is reported here that the major non-integrin LBP of murine macrophages exhibits an Mr of 35,000 and is expressed on the cell surface and is identical to carbohydrate binding protein 35, which is the macrophage antigen Mac-2.
References
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Arg-Gly-Asp: a versatile cell recognition signal.
TL;DR: The RGD sequence as a basic unit of a widespread cellular recognition system is established and the same peptides also inhibit the attachment of fibroblasts to a number of other proteins, including vitronectin.
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Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage
TL;DR: The interaction of the purified CSAT antigen with these cytoskeletal components is investigated, and an interaction specifically between theCSAT antigen and talin is demonstrated.
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Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins.
TL;DR: Recognition of the molecular pathogenesis of this disorder has allowed rich insights into the role of cellular adherence reactions in inflammation and host defense.
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Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor
TL;DR: Affinity chromatography on wheat germ agglutinin-Sepharose showed that the 140 kd protein is a glycoprotein and, in combination with the fibronectin fragment chromatography, gave highly enriched preparations of the 140Kd protein.
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Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors
TL;DR: The results establish the existence of a family of adhesion receptors that recognize the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen.