Journal ArticleDOI
Integrins: a family of cell surface receptors.
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TLDR
This brief review of sequence data from embryogenesis, thrombosis, and lymphocyte help and killing is summarized and attempts to clarify the relationships among the members of this family of cell surface receptors.About:
This article is published in Cell.The article was published on 1987-02-27. It has received 4229 citations till now. The article focuses on the topics: Integrin & Cell adhesion.read more
Citations
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G1/S control of anchorage-independent growth in the fibroblast cell cycle.
T M Guadagno,Richard K. Assoian +1 more
TL;DR: It is indicated that anchorage mediates G1/S control in fibroblasts and identified a physiologic circumstance in which the phenotype of mammalian cell cycle arrest would closely resemble Saccharomyces cerevisiae START.
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Cellular chemomechanics at interfaces: sensing, integration and response
TL;DR: Micro- and nanotechnology-based tools that have been used to study how chemical and mechanical cues modulate the responses of single cells in contact with the extracellular environment are highlighted.
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Identification of integrin-like matrix receptors with affinity for interstitial collagens.
TL;DR: Data is presented indicating that proteins with Mr around 145,000 and 170,000 are associated in noncovalently linked complexes with the Mr 115,000 protein, which indicates the presence of collagen receptors that share the beta-subunit with the HFNR but that are not directed to RGD sequences.
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Cloning of glycoprotein IIIa cDNA from human erythroleukemia cells and localization of the gene to chromosome 17
Jean-Philippe Rosa,Paul F. Bray,Odile Gayet,Geoffrey I. Johnston,Richard G. Cook,Kenneth W. Jackson,Marc A. Shuman,Rodger P. McEver +7 more
TL;DR: The virtual identity of the endothelial and HEL cell cDNA sequences provides direct evidence that GPIIIa is a subunit common to cell-adhesion receptors present in more than one cell type.
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Alpha 7 beta 1 integrin is a component of the myotendinous junction on skeletal muscle.
TL;DR: Differences between these two junctions were developed further using an antibody against phosphotyrosine (PY20), thought to participate in the organization and stabilization of adhesions, and points to possible origins of junctional specificity on muscle.
References
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Arg-Gly-Asp: a versatile cell recognition signal.
TL;DR: The RGD sequence as a basic unit of a widespread cellular recognition system is established and the same peptides also inhibit the attachment of fibroblasts to a number of other proteins, including vitronectin.
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Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage
TL;DR: The interaction of the purified CSAT antigen with these cytoskeletal components is investigated, and an interaction specifically between theCSAT antigen and talin is demonstrated.
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Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins.
TL;DR: Recognition of the molecular pathogenesis of this disorder has allowed rich insights into the role of cellular adherence reactions in inflammation and host defense.
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Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor
TL;DR: Affinity chromatography on wheat germ agglutinin-Sepharose showed that the 140 kd protein is a glycoprotein and, in combination with the fibronectin fragment chromatography, gave highly enriched preparations of the 140Kd protein.
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Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors
TL;DR: The results establish the existence of a family of adhesion receptors that recognize the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen.