Journal ArticleDOI
Integrins: a family of cell surface receptors.
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This brief review of sequence data from embryogenesis, thrombosis, and lymphocyte help and killing is summarized and attempts to clarify the relationships among the members of this family of cell surface receptors.About:
This article is published in Cell.The article was published on 1987-02-27. It has received 4229 citations till now. The article focuses on the topics: Integrin & Cell adhesion.read more
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Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix.
Donald E. Ingber,Judah Folkman +1 more
TL;DR: It is proposed that FGF-stimulated endothelial cells may be "switched" between growth, differentiation, and involution modes during angiogenesis by altering the adhesivity or mechanical integrity of their ECM.
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Cell Spreading and Focal Adhesion Dynamics Are Regulated by Spacing of Integrin Ligands
Elisabetta Ada Cavalcanti-Adam,Tova Volberg,Alexandre Micoulet,Horst Kessler,Benjamin Geiger,Joachim P. Spatz +5 more
TL;DR: It is shown that cell-surface attachment is not sensitive to pattern density, whereas the formation of stable focal adhesions and persistent spreading is, and a critical RGD density is essential for the establishment of mature and stable integrin adhesion, which, in turn, induce efficient cell spreading and formation of focal adhesion dynamics.
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Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis.
TL;DR: It is reported that macrophage recognition of apoptotic cells (both neutrophils and lymphocytes) is mediated by the vitronectin receptor, a heterodimer belonging to the β3 or cytoadhesin family of the integrins.
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Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: The 'red complex', a prototype polybacterial pathogenic consortium in periodontitis
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Sensing the environment: a historical perspective on integrin signal transduction.
Cindy K. Miranti,Joan S. Brugge +1 more
TL;DR: This historical perspective traces the key findings that have led to the current understanding of these important functions of integrins.
References
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Arg-Gly-Asp: a versatile cell recognition signal.
TL;DR: The RGD sequence as a basic unit of a widespread cellular recognition system is established and the same peptides also inhibit the attachment of fibroblasts to a number of other proteins, including vitronectin.
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Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage
TL;DR: The interaction of the purified CSAT antigen with these cytoskeletal components is investigated, and an interaction specifically between theCSAT antigen and talin is demonstrated.
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Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins.
TL;DR: Recognition of the molecular pathogenesis of this disorder has allowed rich insights into the role of cellular adherence reactions in inflammation and host defense.
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Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor
TL;DR: Affinity chromatography on wheat germ agglutinin-Sepharose showed that the 140 kd protein is a glycoprotein and, in combination with the fibronectin fragment chromatography, gave highly enriched preparations of the 140Kd protein.
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Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors
TL;DR: The results establish the existence of a family of adhesion receptors that recognize the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen.