Journal ArticleDOI
Integrins: a family of cell surface receptors.
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TLDR
This brief review of sequence data from embryogenesis, thrombosis, and lymphocyte help and killing is summarized and attempts to clarify the relationships among the members of this family of cell surface receptors.About:
This article is published in Cell.The article was published on 1987-02-27. It has received 4229 citations till now. The article focuses on the topics: Integrin & Cell adhesion.read more
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A role for fibronectin in the migration of avian precardiac cells. II. Rotation of the heart-forming region during different stages and its effects.
Kersti K. Linask,James W. Lash +1 more
TL;DR: It is indicated that precardiac cells do follow cues established by a FN concentration difference at the mesoderm-endoderm interface in the lateral region and that anti-fibronectin can inhibit normal cell migration during heart formation.
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Control of junB and extracellular matrix protein expression by transforming growth factor-beta 1 is independent of simian virus 40 T antigen-sensitive growth-sensitive growth-inhibitory events
Marikki Laiho,Lars Rönnstrand,Jyrki Heino,James A. DeCaprio,J W Ludlow,David M. Livingston,Joan Massagué +6 more
TL;DR: In this article, the effect of transforming growth factor-beta 1 (TGF-beta) on the expression of extracellular matrix proteins in lung epithelial cells has been investigated.
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Fibrinogen acts as a bridging molecule in the adherence of Staphylococcus aureus to cultured human endothelial cells.
TL;DR: Adherence assays were developed to study the role of blood factors in the mediation of staphylococcal adherence to cultured human umbilical vein endothelium in vitro and indicate that the preferential attachment of S. aureus to endothelial cells is mediated by fibrinogen adsorbed from plasma onto the endothelial surface.
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Role of fibronectin-stimulated tumor cell migration in glioma invasion in vivo: clinical significance of fibronectin and fibronectin receptor expressed in human glioma tissues.
Takanori Ohnishi,Shoju Hiraga,Shuichi Izumoto,Hirotaka Matsumura,Yonehiro Kanemura,Norio Arita,Toru Hayakawa +6 more
TL;DR: Fructose deposited in the extracellular matrix of tumors, which can be derived from both plasma and the tumor cell itself, strongly promotes the migration of glioma cells, and that expression of the fibronectin receptor may play a critical role in the biological behavior of the tumor cells, particularly in fibronctin-stimulated cell migration in vivo is suggested.
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The lipoxygenase metabolite 12(S)‐hete induces a cytoskeleton‐dependent increase in surface expression of integrin αiibβ3 on melanoma cells
Hemi Chopra,Jozsef Timar,Yong Q. Chen,Xianhui Rong,Irma M. Grossi,Laurence A. Fitzgerald,John D. Taylor,Kenneth V. Honn +7 more
TL;DR: The lipoxygenase metabolite of arachidonic acid, 120‐(s)‐HETE, regulates the surface expression and function of the αIIbβ3, integrin in B16a cells, and the hypothesis that microfilaments and intermediate filaments have a profound role in regulating the expression of a multifunctional integrin is supported.
References
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Arg-Gly-Asp: a versatile cell recognition signal.
TL;DR: The RGD sequence as a basic unit of a widespread cellular recognition system is established and the same peptides also inhibit the attachment of fibroblasts to a number of other proteins, including vitronectin.
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Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage
TL;DR: The interaction of the purified CSAT antigen with these cytoskeletal components is investigated, and an interaction specifically between theCSAT antigen and talin is demonstrated.
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Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins.
TL;DR: Recognition of the molecular pathogenesis of this disorder has allowed rich insights into the role of cellular adherence reactions in inflammation and host defense.
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Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor
TL;DR: Affinity chromatography on wheat germ agglutinin-Sepharose showed that the 140 kd protein is a glycoprotein and, in combination with the fibronectin fragment chromatography, gave highly enriched preparations of the 140Kd protein.
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Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors
TL;DR: The results establish the existence of a family of adhesion receptors that recognize the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen.