Journal ArticleDOI
Integrins: a family of cell surface receptors.
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TLDR
This brief review of sequence data from embryogenesis, thrombosis, and lymphocyte help and killing is summarized and attempts to clarify the relationships among the members of this family of cell surface receptors.About:
This article is published in Cell.The article was published on 1987-02-27. It has received 4229 citations till now. The article focuses on the topics: Integrin & Cell adhesion.read more
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Journal ArticleDOI
Beyond RGD: virus interactions with integrins.
Hosni A. M. Hussein,Lia R. Walker,Usama M. Abdel-Raouf,Sayed A. Desouky,Abdel Khalek M. Montasser,Shaw M. Akula +5 more
TL;DR: The published literature regarding the role of integrins in terms of virus infection and virus-encoded glycosylated proteins that mediate interactions withIntegrins are examined, and the idea of targeting these receptors as a therapeutic treatment option is explored.
Journal ArticleDOI
Expression of native and truncated forms of the human integrin alpha 1 subunit.
TL;DR: Biosynthetic studies using stably expressing cell lines demonstrate that the soluble heterodimers and the native heterODimers are formed independently, strongly suggesting that the transmembrane or cytoplasmic domains of alpha and beta subunits are involved in the assembly of native heterodIMers.
Patent
Comb copolymers for regulating cell-surface interactions
TL;DR: Synthetic comb copolymers which elicit controlled cellular response, methods of applying these polymers to various surfaces, and methods of using the polymers for modifying biomaterial surfaces, in tissue engineering applications and as drug delivery devices are provided as discussed by the authors.
Journal ArticleDOI
Adhesion molecules as determinants of disease: from molecular biology to surgical research
Michael D. Menger,B. Vollmar +1 more
TL;DR: In this article, the role of cell surface receptors (adhesion molecules) and their role in the biological processes of morphogenesis, cell migration and cell-cell communication has been investigated.
Journal ArticleDOI
Tissue-Specific and Developmentally Regulated Expression of a Cluster of Tandemly Arrayed Cell Wall-Associated Kinase-Like Kinase Genes in Arabidopsis
TL;DR: The characterization of group 2 members that are composed of a cluster of seven tandemly arrayed WAKL genes is described, suggesting that they, like some WAK members, are wound inducible and can be defined as pathogenesis-related genes.
References
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Arg-Gly-Asp: a versatile cell recognition signal.
TL;DR: The RGD sequence as a basic unit of a widespread cellular recognition system is established and the same peptides also inhibit the attachment of fibroblasts to a number of other proteins, including vitronectin.
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Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage
TL;DR: The interaction of the purified CSAT antigen with these cytoskeletal components is investigated, and an interaction specifically between theCSAT antigen and talin is demonstrated.
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Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins.
TL;DR: Recognition of the molecular pathogenesis of this disorder has allowed rich insights into the role of cellular adherence reactions in inflammation and host defense.
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Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor
TL;DR: Affinity chromatography on wheat germ agglutinin-Sepharose showed that the 140 kd protein is a glycoprotein and, in combination with the fibronectin fragment chromatography, gave highly enriched preparations of the 140Kd protein.
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Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors
TL;DR: The results establish the existence of a family of adhesion receptors that recognize the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen.