Journal ArticleDOI
Integrins: a family of cell surface receptors.
Reads0
Chats0
TLDR
This brief review of sequence data from embryogenesis, thrombosis, and lymphocyte help and killing is summarized and attempts to clarify the relationships among the members of this family of cell surface receptors.About:
This article is published in Cell.The article was published on 1987-02-27. It has received 4229 citations till now. The article focuses on the topics: Integrin & Cell adhesion.read more
Citations
More filters
Journal ArticleDOI
A Requirement for Caveolin-1 and Associated Kinase Fyn in Integrin Signaling and Anchorage-Dependent Cell Growth
TL;DR: Findings reveal an unexpected function of caveolin-1 and Fyn in integrin signaling and anchorage-dependent cell growth and couple integrins to the Ras-ERK pathway and promote cell cycle progression.
Journal ArticleDOI
Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane
TL;DR: It is reported that tissue-specific vectorial secretion coincides with the formation of functional alveoli-like structures by primary mammary epithelial cells cultured on a reconstituted basement membrane matrix (derived from Engelbreth-Holm-Swarm murine tumour), which reproduce the dual role of mammaries to secrete vectorially and to sequester milk proteins.
Journal ArticleDOI
Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule.
TL;DR: It is demonstrated that PECAM-1 mediates cell-cell adhesion and support the idea that it may be involved in some of the interactive events taking place during thrombosis, wound healing, and angiogenesis.
Journal ArticleDOI
Binding of brain-derived neurotrophic factor to the nerve growth factor receptor
TL;DR: It is found that a 1000-fold excess of the heterologous ligand is needed to reduce binding to the high-affinity receptor by 50%, but that the same concentrations of BDNF and NGF similarly reduce the binding of either ligand to the low-Affinity receptor.
Journal ArticleDOI
Axon guidance and the patterning of neuronal projections in vertebrates
Jane Dodd,Thomas M. Jessell +1 more
TL;DR: Over the past decade, new insights have been obtained into the cellular strategies and molecular mechanisms that guide axons to their targets in the developing vertebrate nervous system.
References
More filters
Journal ArticleDOI
Arg-Gly-Asp: a versatile cell recognition signal.
TL;DR: The RGD sequence as a basic unit of a widespread cellular recognition system is established and the same peptides also inhibit the attachment of fibroblasts to a number of other proteins, including vitronectin.
Journal ArticleDOI
Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage
TL;DR: The interaction of the purified CSAT antigen with these cytoskeletal components is investigated, and an interaction specifically between theCSAT antigen and talin is demonstrated.
Journal ArticleDOI
Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins.
TL;DR: Recognition of the molecular pathogenesis of this disorder has allowed rich insights into the role of cellular adherence reactions in inflammation and host defense.
Journal ArticleDOI
Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor
TL;DR: Affinity chromatography on wheat germ agglutinin-Sepharose showed that the 140 kd protein is a glycoprotein and, in combination with the fibronectin fragment chromatography, gave highly enriched preparations of the 140Kd protein.
Journal ArticleDOI
Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors
TL;DR: The results establish the existence of a family of adhesion receptors that recognize the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen.