Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer.
Takashi Nishina,Yutaka Deguchi,Daisuke Ohshima,Wakami Takeda,Wakami Takeda,Masato Ohtsuka,Shigeyuki Shichino,Satoshi Ueha,Soh Yamazaki,Mika Kawauchi,Eri Nakamura,Chiharu Nishiyama,Yuko Kojima,Satomi Adachi-Akahane,Mizuho Hasegawa,Mizuho Nakayama,Masanobu Oshima,Hideo Yagita,Kazutoshi Shibuya,Tetuo Mikami,Naohiro Inohara,Kouji Matsushima,Norihiro Tada,Hiroyasu Nakano +23 more
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TLDR
In this paper, the origin and functions of IL-11-producing (IL-11+) cells are not fully understood, but they appear in the colon in murine tumor and acute colitis models and express fibroblast markers and genes associated with cell proliferation and tissue repair.Abstract:
Interleukin (IL)-11 is a member of the IL-6 family of cytokines and is involved in multiple cellular responses, including tumor development. However, the origin and functions of IL-11-producing (IL-11+) cells are not fully understood. To characterize IL-11+ cells in vivo, we generate Il11 reporter mice. IL-11+ cells appear in the colon in murine tumor and acute colitis models. Il11ra1 or Il11 deletion attenuates the development of colitis-associated colorectal cancer. IL-11+ cells express fibroblast markers and genes associated with cell proliferation and tissue repair. IL-11 induces the activation of colonic fibroblasts and epithelial cells through phosphorylation of STAT3. Human cancer database analysis reveals that the expression of genes enriched in IL-11+ fibroblasts is elevated in human colorectal cancer and correlated with reduced recurrence-free survival. IL-11+ fibroblasts activate both tumor cells and fibroblasts via secretion of IL-11, thereby constituting a feed-forward loop between tumor cells and fibroblasts in the tumor microenvironment.read more
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Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing
Guadalupe J. Jasso,Alok Jaiswal,Mukund Varma,Tyler Laszewski,Angelo Grauel,Abdifatah S. Omar,Nilsa Silva,Glenn Dranoff,Jeffrey A. Porter,Keith G. Mansfield,Viviana Cremasco,Aviv Regev,Ramnik J. Xavier,Daniel B. Graham +13 more
TL;DR: A critical role for the metalloprotease Adamdec1 at the interface between tissue remodeling and healing during colitis is supported, demonstrating its requirement for colon epithelial integrity.
Journal ArticleDOI
The Versatile Roles of Cancer-Associated Fibroblasts in Colorectal Cancer and Therapeutic Implications.
TL;DR: In this paper, the authors outline the emerging concept of cancer-associated fibroblasts in colorectal cancer, with an emphasis on their origins, biomarkers, prognostic significance, as well as their functional roles and underlying mechanisms in CRC biology.
Journal ArticleDOI
Interleukin-11 signaling promotes cellular reprogramming and limits fibrotic scarring during tissue regeneration
Srinivas Allanki,Srinivas Allanki,Boris Strilic,Lilly Scheinberger,Yeszamin L. Onderwater,Alora Marks,Stefan Günther,Jens Preussner,Khrievono Kikhi,Mario Looso,Didier Y.R. Stainier,Sven Reischauer,Sven Reischauer +12 more
TL;DR: In contrast, species like zebrafish can regenerate damaged tissues without excessive fibribr... as mentioned in this paper, which is a leading cause of morbidity in mammals and is the most common cause of fibrotic scarring.
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The Analysis of Inflammation-Related Proteins in a Cargo of Exosomes Derived from the Serum of Uveal Melanoma Patients Reveals Potential Biomarkers of Disease Progression.
Joanna Wróblewska,Michał Stefan Lach,Katarzyna Kulcenty,Łukasz Galus,Wiktoria Maria Suchorska,Daniel Rösel,Jan Brábek,Andrzej Marszałek +7 more
TL;DR: In this article, a panel of exosomal proteins for early detection of uveal melanoma progression into metastatic disease was proposed based on the obtained results, which showed a significant correlation between the disease stage and the concentration of these inflammation-related proteins from exosome cargo.
Journal ArticleDOI
IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues
Anissa A. Widjaja,Sonia Chothani,Sivakumar Viswanathan,Joyce Goh Wei Ting,Wei-Wen Lim,Stuart A. Cook +5 more
TL;DR: RNA sequencing over a time course of IL11 stimulation revealed a robust short-lived transcriptional response, which was enriched for gene set hallmarks of inflammation and characterized by upregulation of SERPINB2, TNFRSF18, IL33, CCL20, IL1RL1, CXCL3/5/8, ICAM1 and IL11 itself.
References
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