Interleukin (IL)-1F6, IL-1F8, and IL-1F9 Signal through IL-1Rrp2 and IL-1RAcP to Activate the Pathway Leading to NF-κB and MAPKs
TLDR
It is demonstrated that IL-1F6 and IL- 1F8, in addition to IL-2F9, activate the pathway leading to NF-κB in an IL-3Rrp2-dependent manner in Jurkat cells as well as in multiple other human and mouse cell lines, and thatIL-1RrP2 antibodies block activation of the pathwayLeading to NF -κB by IL-0F6, IL-8, and Il-1About:
This article is published in Journal of Biological Chemistry.The article was published on 2004-04-02 and is currently open access. It has received 395 citations till now. The article focuses on the topics: Jurkat cells & Interleukin 36 receptor antagonist.read more
Citations
More filters
Journal ArticleDOI
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
Jochen Schmitz,Alexander Owyang,Elizabeth R. Oldham,Yaoli Song,Erin Murphy,Terril K. McClanahan,Gerard Zurawski,Mehrdad M. Moshrefi,Jinzhong Qin,Xiaoxia Li,Daniel M. Gorman,J. Fernando Bazan,Robert A. Kastelein +12 more
TL;DR: A member of theIL-1 family, IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T( H)2 cells is reported.
Journal ArticleDOI
Immunological and Inflammatory Functions of the Interleukin-1 Family
TL;DR: The IL-1 family includes members that suppress inflammation, both specifically within the IL-2 family but also nonspecifically for TLR ligands and the innate immune response.
Journal ArticleDOI
The IL-1 family: regulators of immunity
John E. Sims,Dirk E. Smith +1 more
TL;DR: This Review provides an overview of both the long-established and more recently characterized members of the IL-1 family and their effects on immune cells, their involvement in human disease and disease models is discussed.
Journal ArticleDOI
An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist
Ivona Aksentijevich,Seth L. Masters,Polly J. Ferguson,Paul Dancey,Joost Frenkel,Annet van Royen-Kerkhoff,R. M. Laxer,Ulf Tedgård,Edward W. Cowen,Tuyet-Hang Pham,Matthew G. Booty,Jacob D. Estes,Netanya G. Sandler,Nicole Plass,Deborah L. Stone,Maria L. Turner,Suvimol Hill,John A. Butman,Rayfel Schneider,Paul Babyn,Hatem El-Shanti,Elena Pope,Karyl S. Barron,Xinyu Bing,Arian Laurence,Chyi-Chia Richard Lee,Dawn Chapelle,Gillian I. Clarke,Kamal Ohson,Marc Nicholson,Massimo Gadina,Barbara Yang,Benjamin D. Korman,Peter K. Gregersen,P. Martin van Hagen,A. Elisabeth Hak,Marjan Huizing,Proton Rahman,Daniel C. Douek,Elaine F. Remmers,Daniel L. Kastner,Raphaela Goldbach-Mansky +41 more
TL;DR: The term deficiency of the interleukin-1-receptor antagonist, or DIRA, is proposed to denote this autosomal recessive autoinflammatory disease caused by mutations affecting IL1RN, resulting in life-threatening systemic inflammation with skin and bone involvement.
Journal ArticleDOI
Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis
Slaheddine Marrakchi,Philippe Guigue,Blair R. Renshaw,Anne Puel,Xue-Yuan Pei,Sylvie Fraitag,Jihen Zribi,Elodie Bal,Céline Cluzeau,Maya Chrabieh,Jennifer E. Towne,Jason Douangpanya,Christian Pons,Sourour Mansour,Valérie Serre,Hafedh Makni,Nadia Mahfoudh,Faiza Fakhfakh,Christine Bodemer,Josué Feingold,Smail Hadj-Rabia,Michel Favre,Emmanuelle Génin,Mourad Sahbatou,Arnold Munnich,Jean-Laurent Casanova,John E. Sims,Hamida Turki,Hervé Bachelez,Asma Smahi +29 more
TL;DR: Aberrant interleukin-36Ra structure and function lead to unregulated secretion of inflammatory cytokines and generalized pustular psoriasis.
References
More filters
Journal ArticleDOI
Cloning of a new cytokine that induces IFN-gamma production by T cells.
Haruki Okamura,H Tsutsi,T Komatsu,M Yutsudo,A Hakura,T Tanimoto,K Torigoe,T Okura,Y Nukada,K Hattori +9 more
TL;DR: The cloning of a recently identified IFN-γ-inducing factor (IGIF) that augments natural killer activity in spleen cells and may be involved in the development of Thl cells and also in mechanisms of tissue injury in inflammatory reactions is reported.
Journal ArticleDOI
Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth.
Harikrishna Nakshatri,Poornima Bhat-Nakshatri,Daniel A. Martin,Robert J. Goulet,George W. Sledge +4 more
TL;DR: Since ER inhibits the constitutive as well as inducible activation function of NF-kappaB in a dose-dependent manner, it is proposed that breast cancers that lack functional ER overexpress NF- kappaB-regulated genes.
Journal Article
IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production.
Tomohiro Yoshimoto,Kiyoshi Takeda,Takashi Tanaka,Kazunobu Ohkusu,Shin-ichiro Kashiwamura,Haruki Okamura,Shizuo Akira,Kenji Nakanishi +7 more
TL;DR: It is shown that IL-12 and IL-18 promptly and synergistically induce T and B cells to develop into IFN-gamma-producing cells without engaging their Ag receptors and the mechanism underlying differences inIL-18 responsiveness between Th1 and Th2 cells is studied.
Journal ArticleDOI
Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist.
TL;DR: There is growing evidence that the production and activity of IL-1, particularly IL- 1 beta, are tightly regulated events as if nature has placed specific "road blocks" to reduce the response toIL-1 during disease.
Journal ArticleDOI
Interleukin-18 Binding Protein: A Novel Modulator of the Th1 Cytokine Response
Daniela Novick,Soohyun Kim,Giamila Fantuzzi,Leonid L. Reznikov,Charles A. Dinarello,Menachem Rubinstein +5 more
TL;DR: Interleukin-18 binding protein functions as an inhibitor of the early Th1 cytokine response, suggesting that viral products may attenuate IL-18 and interfere with the cytotoxic T cell response.
Related Papers (5)
Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis
Slaheddine Marrakchi,Philippe Guigue,Blair R. Renshaw,Anne Puel,Xue-Yuan Pei,Sylvie Fraitag,Jihen Zribi,Elodie Bal,Céline Cluzeau,Maya Chrabieh,Jennifer E. Towne,Jason Douangpanya,Christian Pons,Sourour Mansour,Valérie Serre,Hafedh Makni,Nadia Mahfoudh,Faiza Fakhfakh,Christine Bodemer,Josué Feingold,Smail Hadj-Rabia,Michel Favre,Emmanuelle Génin,Mourad Sahbatou,Arnold Munnich,Jean-Laurent Casanova,John E. Sims,Hamida Turki,Hervé Bachelez,Asma Smahi +29 more