Is any but a tiny fraction of handedness variance likely to be due to the external environment
TLDR
In this paper, non-shared environmental variance (NSEV) accounts for 76% of variance in genetic modelling of handedness and it is very misleading to suggest that NSEV, "highlights the importance of non-gene...Abstract:
Non-shared environmental variance (NSEV) accounts for 76% of variance in genetic modelling of handedness. However, it is very misleading to suggest that NSEV, “highlights the importance of non-gene...read more
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Journal ArticleDOI
Handedness and its genetic influences are associated with structural asymmetries of the cerebral cortex in 31,864 individuals.
Zhiqiang Sha,Antonietta Pepe,Antonietta Pepe,Antonietta Pepe,Dick Schijven,Amaia Carrion-Castillo,James M Roe,René Westerhausen,Marc Joliot,Marc Joliot,Marc Joliot,Simon E. Fisher,Simon E. Fisher,Fabrice Crivello,Fabrice Crivello,Fabrice Crivello,Clyde Francks,Clyde Francks +17 more
TL;DR: In this paper, structural brain image data from 28,802 right handers and 3,062 left handers were resampled to a symmetrical surface template, and mapped asymmetries for each of 8,681 vertices across the cerebral cortex in each individual.
Journal ArticleDOI
Recent Advances in Handedness Genetics
TL;DR: The latest findings from molecular genetic studies are reviewed as well as the implications of using different ways of assessing handedness, which demonstrate that handedness is a highly polygenic trait.
Journal ArticleDOI
Cerebral Polymorphisms for Lateralisation: Modelling the Genetic and Phenotypic Architectures of Multiple Functional Modules
TL;DR: The original, monogenic McManus DC (dextral-chance) model of handedness and language dominance is extended to multiple functional modules, and to a polygenic DC model compatible with the molecular genetics ofhandedness, and with the biology of visceral asymmetries found in primary ciliary dyskinesia.
Journal ArticleDOI
It Is Not Just in the Genes
TL;DR: In this article, a review combines data from human and animal research (especially on birds) and outlines a multi-level model for asymmetry formation in the human brain, showing that the relative impact of genetic and nongenetic factors varies between different developmental phases and neuronal structures.
Journal ArticleDOI
DNA methylation in peripheral tissues and left-handedness
TL;DR: In a meta-analysis of 3914 adults of whole-blood DNA methylation, this paper found that CpG sites located in proximity of handedness-associated genetic variants were more strongly associated with left-handedness than other sites (P = 0.04), but did not identify any differentially methylated positions.
References
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Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles
TL;DR: In the present study, 2-NBA, 3-NBA and selected PAHs and Nitro-PAHs were determined in fine particle samples collected in a bus station and an outdoor site, showing low cancer risk incidence and incremental lifetime cancer risk (ILCR) calculated for both places.
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The distribution of manual asymmetry
TL;DR: It is concluded that the basic normal distribution probably depends on accidental variation while the human shift to the right may be a product of both cultural and genetic influences.
Journal ArticleDOI
Genetic influences on handedness: Data from 25,732 Australian and Dutch twin families
Sarah E. Medland,Sarah E. Medland,David L. Duffy,Margaret J. Wright,Gina M. Geffen,David A. Hay,Florence Levy,Catherina E.M. van-Beijsterveldt,Gonneke Willemsen,Grant Townsend,Vicki White,Alex W. Hewitt,David A. Mackey,J. Michael Bailey,Wendy S. Slutske,Dale R. Nyholt,Susan A. Treloar,Nicholas G. Martin,Dorret I. Boomsma +18 more
TL;DR: Analysis from a large international collaborative study of handedness in Australian and Dutch twins and their siblings revealed no evidence of hormonal transfer, mirror imaging or twin specific effects and additive genetic effects accounted for about a quarter of the variance.
Journal ArticleDOI
Commentary: Why are children in the same family so different? Non-shared environment three decades later
TL;DR: Reflecting on non-shared environment three decades after the topic emerged is to suggest some new directions for research in this area.
Journal ArticleDOI
Some genetic tests on asymmetry of sternopleural chaeta number in Drosophila
TL;DR: The experimental evidence suggests that sternopleural asymmetry cannot be considered a measure of general developmental stability, particularly as the level of asymmetry can be reduced by selection well below that of typical wild stocks.
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