JAK-STAT Pathway: A Novel Target to Tackle Viral Infections
TLDR
In this article, the authors review the diversity of strategies that viruses have evolved to interfere with JAK-STAT signaling, stressing the relevance of this pathway as a putative antiviral target.Abstract:
Modulation of the antiviral innate immune response has been proposed as a putative cellular target for the development of novel pan-viral therapeutic strategies. The Janus kinase–signal transducer and activator of transcription (JAK-STAT) pathway is especially relevant due to its essential role in the regulation of local and systemic inflammation in response to viral infections, being, therefore, a putative therapeutic target. Here, we review the extraordinary diversity of strategies that viruses have evolved to interfere with JAK-STAT signaling, stressing the relevance of this pathway as a putative antiviral target. Moreover, due to the recent remarkable progress on the development of novel JAK inhibitors (JAKi), the current knowledge on its efficacy against distinct viral infections is also discussed. JAKi have a proven efficacy against a broad spectrum of disorders and exhibit safety profiles comparable to biologics, therefore representing good candidates for drug repurposing strategies, including viral infections.read more
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Infectious Bronchitis Virus Nsp14 Degrades JAK1 to Inhibit the JAK-STAT Signaling Pathway in HD11 Cells
Peng Ma,Kui Gu,HaoCheng Li,Yu Zhao,Chao Li,Renqiao Wen,Chang Zhou,Chang-Wei Lei,Xin Yang,Hongning Wang +9 more
TL;DR: It is reported that IBV Nsp14 was a JAK-STAT signaling pathway antagonist in chicken macrophage (HD11) cells, indicating a novel mechanism by which IBV inhibits the host antiviral response and provide new insights into the selection of antiviral targets against CoV.
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HSP90AA1 interacts with CSFV NS5A protein and regulates CSFV replication via the JAK/STAT and NF-κB signaling pathway
Chenchen Liu,Wei Zhao,Jiankun Su,Xiaochun Chen,Fei-Yan Zhao,Jindai Fan,Xiaowen Li,Xiaodi Liu,L. Zou,Mengru Zhang,Zilin Zhang,Liangliang Zhang,Shuangqi Fan,Yuwan Li,Mingqiu Zhao,Jinding Chen,Lin Yi +16 more
TL;DR: Wang et al. as mentioned in this paper found that HSP90AA1 overexpression significantly inhibited CSFV replication and may inhibit SCV replication by interacting with NS5A and activating JAK/STAT and NF-κB signaling pathways.
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