Lessons From the Testosterone Trials
Peter J. Snyder,Shalender Bhasin,Glenn R. Cunningham,Alvin M. Matsumoto,Alisa J. Stephens-Shields,Jane A. Cauley,Thomas M. Gill,Elizabeth Barrett-Connor,Ronald S. Swerdloff,Christina Wang,Kristine E. Ensrud,Kristine E. Ensrud,Cora E. Lewis,John T. Farrar,David Cella,Raymond C. Rosen,Marco Pahor,Jill P. Crandall,Mark E. Molitch,Susan M. Resnick,Matthew J. Budoff,Emile R. Mohler,Nanette K. Wenger,Harvey J. Cohen,Stanley L. Schrier,Tony M. Keaveny,David L. Kopperdahl,David Lee,Denise Cifelli,Susan S. Ellenberg +29 more
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TLDR
Although testosterone was not associated with more cardiovascular or prostate adverse events than placebo, a trial of a much larger number of men for a much longer period would be necessary to determine whether testosterone increases cardiovascular or Prostate risk.Abstract:
The Testosterone Trials (TTrials) were a coordinated set of seven placebo-controlled, double-blind trials in 788 men with a mean age of 72 years to determine the efficacy of increasing the testosterone levels of older men with low testosterone. Testosterone treatment increased the median testosterone level from unequivocally low at baseline to midnormal for young men after 3 months and maintained that level until month 12. In the Sexual Function Trial, testosterone increased sexual activity, sexual desire, and erectile function. In the Physical Function Trial, testosterone did not increase the distance walked in 6 minutes in men whose walk speed was slow; however, in all TTrial participants, testosterone did increase the distance walked. In the Vitality Trial, testosterone did not increase energy but slightly improved mood and depressive symptoms. In the Cognitive Function Trial, testosterone did not improve cognitive function. In the Anemia Trial, testosterone increased hemoglobin in both men who had anemia of a known cause and in men with unexplained anemia. In the Bone Trial, testosterone increased volumetric bone mineral density and the estimated strength of the spine and hip. In the Cardiovascular Trial, testosterone increased the coronary artery noncalcified plaque volume as assessed using computed tomographic angiography. Although testosterone was not associated with more cardiovascular or prostate adverse events than placebo, a trial of a much larger number of men for a much longer period would be necessary to determine whether testosterone increases cardiovascular or prostate risk.read more
Citations
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Cardiovascular Risks Associated with Gender and Aging.
Jennifer L. Rodgers,Jarrod Jones,Samuel Ignatious Bolleddu,Sahit Vanthenapalli,Lydia E. Rodgers,Kinjal Shah,Krishna Karia,Siva K. Panguluri +7 more
TL;DR: Current findings regarding the impacts of age and gender on heart disease are discussed and hormone replacement therapies are largely shown to not improve outcomes in older patients and may also increase the risks of cardiac events in older adults.
Journal ArticleDOI
Using human genetics to understand the disease impacts of testosterone in men and women
Katherine S. Ruth,Felix R. Day,Jessica Tyrrell,Deborah J. Thompson,Andrew R. Wood,Anubha Mahajan,Robin N Beaumont,Laura B. L. Wittemans,Laura B. L. Wittemans,Susan Martin,Alexander S Busch,Alexander S Busch,A. Mesut Erzurumluoglu,Benjamin Hollis,Tracy A. O'Mara,Mark I. McCarthy,Claudia Langenberg,Douglas F. Easton,Nicholas J. Wareham,Stephen Burgess,Anna Murray,Ken K. Ong,Ken K. Ong,Timothy M. Frayling,John R. B. Perry +24 more
TL;DR: Genetic analysis of data from over 400,000 participants in the UK Biobank Study shows that circulating testosterone levels have sex-specific implications for cardiometabolic diseases and cancer outcomes and the genetic determinants of testosterone levels are substantially different between sexes.
Journal ArticleDOI
European Association of Urology Guidelines on Sexual and Reproductive Health-2021 Update: Male Sexual Dysfunction.
Andrea Salonia,C Bettocchi,Luca Boeri,Paolo Capogrosso,Joana Carvalho,Nusret Can Cilesiz,Andrea Cocci,Giovanni Corona,Kostantinos Dimitropoulos,Murat Gul,Georgios Hatzichristodoulou,T Hugh Jones,Ates Kadioglu,Juan Ignatio Martínez Salamanca,Uros Milenkovic,Vaibhav Modgil,Giorgio Ivan Russo,Ege Can Serefoglu,Tharu Tharakan,Paolo Verze,Suks Minhas +20 more
TL;DR: The European Association of Urology (EAU) guidelines on male sexual health were updated in March 2019, with a last comprehensive update in January 2019 as mentioned in this paper, with a systematic review of the evidence or a consensus opinion from the expert panel.
Journal ArticleDOI
European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: Endorsing organization: European Society of Endocrinology.
Giovanni Corona,Dimitrios G. Goulis,Ilpo Huhtaniemi,Ilpo Huhtaniemi,Michael Zitzmann,Jorma Toppari,Jorma Toppari,Gianni Forti,Dirk Vanderschueren,Frederick C. W. Wu +9 more
TL;DR: Evidence regarding functional hypog onadism, previously referred to as ‘late‐onset’ hypogonadism’, has increased substantially during the last 10 year.
Journal ArticleDOI
Association of Testosterone Treatment With Alleviation of Depressive Symptoms in Men: A Systematic Review and Meta-analysis.
TL;DR: Testosterone treatment appears to be effective and efficacious in reducing depressive symptoms in men, particularly when higher-dosage regimens were applied in carefully selected samples, although the heterogeneity of the included RCTs means more preregistered trials are needed.
References
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