Journal ArticleDOI
LyP-1-conjugated nanoparticles for targeting drug delivery to lymphatic metastatic tumors.
Guopei Luo,Xianjun Yu,Chen Jin,Feng Yang,Deliang Fu,Jiang Long,Jin Xu,Changyou Zhan,Weiyue Lu +8 more
TLDR
This study indicates that LyP-1-NP is a promising carrier for target-specific drug delivery to lymphatic metastatic tumors.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2010-01-29. It has received 149 citations till now. The article focuses on the topics: Drug delivery & Drug carrier.read more
Citations
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PLGA-based nanoparticles: An overview of biomedical applications
Fabienne Danhier,Eduardo Ansorena,Joana M. Silva,Joana M. Silva,Régis Coco,Aude Le Breton,Véronique Préat +6 more
TL;DR: This review presents why PLGA has been chosen to design nanoparticles as drug delivery systems in various biomedical applications such as vaccination, cancer, inflammation and other diseases.
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Cancer Nanotechnology: The impact of passive and active targeting in the era of modern cancer biology
TL;DR: The fundamental concepts of enhanced permeability and retention effect (EPR) are revisited and the mechanisms proposed to enhance preferential "retention" in the tumor, whether using active targeting of nanoparticles, binding of drugs to their tumoral targets or the presence of tumor associated macrophages are explored.
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Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery
TL;DR: This review will focus on the nature of the polymers involved in the preparation of targeted nanocarriers, the synthesis methods to achieve the desired macromolecular architecture, the selected coupling strategy, and the choice of the homing molecules (vitamins, hormones, peptides, proteins, etc.), as well as the various strategies to display them at the surface of nanoccarriers.
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Nanoparticles as drug delivery systems
TL;DR: Various nanostructures, including liposomes, polymers, dendrimers, silicon or carbon materials, and magnetic nanoparticles, have been tested as carriers in drug delivery systems and their connections with drugs are analyzed.
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Polymeric nanoparticles for targeted drug delivery system for cancer therapy.
TL;DR: In this review, the current implications of encapsulation of anticancer agents within polyhydroxyalkanoates, poly-(lactic-co-glycolic acid) and cyclodextrin based nanoparticles to precisely target the tumor site are highlighted and the promising perspectives in this emerging field are discussed.
References
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Biodegradable polymeric nanoparticles as drug delivery devices
TL;DR: This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.
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Nanoparticle and targeted systems for cancer therapy.
TL;DR: This review explores recent work directed towards more targeted treatment of cancer, whether through more specific anti-cancer agents or through methods of delivery, including delivery by avoiding the reticuloendothelial system, utilizing the enhanced permeability and retention effect and tumor-specific targeting.
Journal ArticleDOI
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
Omid C. Farokhzad,Jianjun Cheng,Jianjun Cheng,Benjamin A. Teply,Ines Sherifi,Sangyong Jon,Philip W. Kantoff,Jerome P. Richie,Robert Langer,Robert Langer +9 more
TL;DR: The potential utility of nanoparticle-aptamer bioconjugates for a therapeutic application is demonstrated and remarkable efficacy and reduced toxicity as measured by mean body weight loss (BWL) in vivo are demonstrated.
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Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery
Jianjun Cheng,Benjamin A. Teply,Benjamin A. Teply,Ines Sherifi,Ines Sherifi,Josephine Sung,Gaurav Luther,Frank X. Gu,Etgar Levy-Nissenbaum,Etgar Levy-Nissenbaum,Aleksandar Filip Radovic-Moreno,Robert Langer,Omid C. Farokhzad,Omid C. Farokhzad +13 more
TL;DR: It is found that NP mean volumetric size correlates linearly with polymer concentration for NPs between 70 and 250 nm in diameter and the ability to control NP size together with targeted delivery may result in favorable biodistribution and development of clinically relevant targeted therapies.
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Lymphangiogenesis in development and human disease
Kari Alitalo,Kari Alitalo,Tuomas Tammela,Tuomas Tammela,Tatiana V. Petrova,Tatiana V. Petrova +5 more
TL;DR: The lymphatic vasculature forms a vessel network that drains interstitial fluid from tissues and returns it to the blood in an important role in the pathogenesis of several diseases, including cancer, lymphoedema and various inflammatory conditions.