Journal ArticleDOI
Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation.
Alexander W. Fischer,Alexander W. Fischer,Michelle Y. Jaeckstein,Kristina Gottschling,Markus Heine,Frederike Sass,N. Mangels,Christian Schlein,Anna Worthmann,Oliver T. Bruns,Yucheng Yuan,Hua Zhu,Ou Chen,Harald Ittrich,Stefan K. Nilsson,Patrik Stefanicka,Jozef Ukropec,Miroslav Balaz,Hua Dong,Wenfei Sun,Rudolf Reimer,Ludger Scheja,Joerg Heeren +22 more
TLDR
In this article, vascular endothelial cells in adipose tissues endocytose substantial amounts of triglyceride-rich lipoproteins (TRL) particles, which subsequently follow the endosomal-lysosomal pathway, where they undergo lysosomal acid lipase (LAL)-mediated processing.About:
This article is published in Cell Metabolism.The article was published on 2021-03-02. It has received 34 citations till now. The article focuses on the topics: Adipose tissue & White adipose tissue.read more
Citations
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Journal ArticleDOI
Metabolic-associated fatty liver disease and lipoprotein metabolism.
Joerg Heeren,Ludger Scheja +1 more
TL;DR: In this article, a review article discusses recent research addressing hepatic lipid synthesis, VLDL production, and lipoprotein internalization as well as the lipid exchange between adipose tissue and the liver in the context of metabolic-associated fatty liver disease.
Journal ArticleDOI
Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment.
TL;DR: In this paper, convergent and disparate metabolic networks regulated by oncogenic mutant KRAS in colon, lung and pancreas tumours, with an emphasis on cooccurring mutations and the role of the tumour microenvironment.
Journal ArticleDOI
Addressing dyslipidemic risk beyond LDL-cholesterol
TL;DR: In this paper , Apolipoprotein C3 (APOC3) and angiopoietin-like 3 (ANGPTL3) have emerged as targets for inhibition by antibody, antisense, or RNAi approaches.
Journal ArticleDOI
Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine
Birte Niemann,Saskia Haufs-Brusberg,Laura Puetz,Martin Feickert,Michelle Y. Jaeckstein,Anne Hoffmann,Jelena Zurkovic,Markus Heine,Eva-Maria Trautmann,Christa E. Müller,Anke Tönjes,Christian Schlein,Azin Jafari,Holger K. Eltzschig,Thorsten Gnad,Matthias Blüher,Natalie Krahmer,Peter Kovacs,Joerg Heeren,Alexander Pfeifer +19 more
TL;DR: In this article , an untargeted metabolomics demonstrated that apoptotic brown adipocytes release a specific pattern of metabolites with purine metabolites being highly enriched, which is mediated by the purine inosine that stimulates energy expenditure in brown adipocyte by the cyclic adenosine monophosphate-protein kinase A signalling pathway.
Journal ArticleDOI
Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia
TL;DR: An overview of the pathways involved in triglyceride-rich lipoprotein (TRL) assembly and intravascular processing is provided, and how the dysregulation of triglyceride transport can result in hypertriglyceridaemia is discussed.
References
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Comprehensive Integration of Single-Cell Data.
Tim Stuart,Andrew Butler,Paul J. Hoffman,Christoph Hafemeister,Efthymia Papalexi,William M. Mauck,Yuhan Hao,Marlon Stoeckius,Peter Smibert,Rahul Satija +9 more
TL;DR: A strategy to "anchor" diverse datasets together, enabling us to integrate single-cell measurements not only across scRNA-seq technologies, but also across different modalities.
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Brown Adipose Tissue: Function and Physiological Significance
Barbara Cannon,Jan Nedergaard +1 more
TL;DR: The development of brown adipose tissue with its characteristic protein, uncoupling protein-1 (UCP1), was probably determinative for the evolutionary success of mammals, as its thermogenesis enhances neonatal survival and allows for active life even in cold surroundings.
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Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Jun Wu,Pontus Boström,Lauren M. Sparks,Li Ye,Jang Hyun Choi,An Hoa Giang,Melin J. Khandekar,Kirsi A. Virtanen,Pirjo Nuutila,Gert Schaart,Kexin Huang,Hua Tu,Wouter D. van Marken Lichtenbelt,Joris Hoeks,Sven Enerbäck,Patrick Schrauwen,Bruce M. Spiegelman +16 more
TL;DR: Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin, providing evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes.
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Size-dependent internalization of particles via the pathways of clathrin-and caveolae-mediated endocytosis
TL;DR: The data indicate that the size itself of (ligand-devoid) particles can determine the pathway of entry in non-phagocytic B16 cells, and kinetic parameters may determine the almost exclusive internalization of such particles along this pathway rather than via caveolae.
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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.
Gregg L. Semenza,Guang L. Wang +1 more
TL;DR: A functionally tripartite, 50-nt hypoxia-inducible enhancer which binds several nuclear factors, one of which is induced by Hypoxia via de novo protein synthesis.