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Journal ArticleDOI

Magnetic resonance imaging for evaluation of Crohn's disease: validation of parameters of severity and quantitative index of activity.

TLDR
The MRI variables that should be evaluated in clinical practice to diagnose active CD and severe CD are validated, as well as the quantitative index of activity for use in research studies.
Abstract
Background:The use of magnetic resonance imaging (MRI) for assessment of Crohn's disease (CD) is expanding. The aim of this study is to define and provide an external validation of the MRI predictors of active CD, severe CD, and a quantitative Magnetic Resonance Index of Activity (MaRIA).Met

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Citations
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Journal ArticleDOI

Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target.

TL;DR: Evidence- and consensus-based recommendations for selecting the goals for treat-to-target strategies in patients with IBD are made available and future studies are needed to determine how these targets will change disease course and patients’ quality of life.
Journal ArticleDOI

British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults

Christopher A. Lamb, +41 more
- 27 Sep 2019 - 
TL;DR: Comprehensive up-to-date guidance is provided regarding indications for, initiation and monitoring of immunosuppressive therapies, nutrition interventions, pre-, peri- and postoperative management, as well as structure and function of the multidisciplinary team and integration between primary and secondary care.
Journal ArticleDOI

Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease.

TL;DR: These guidelines are intended to give practical (whenever possible evidence-based) answers to (pediatric) gastroenterologists who take care of children and adolescents with CD, since many different clinical scenario exist requiring treatment strategies not covered by or different from these guidelines.
References
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Journal ArticleDOI

Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors

TL;DR: In this article, an easily interpretable index of predictive discrimination as well as methods for assessing calibration of predicted survival probabilities are discussed, which are particularly needed for binary, ordinal, and time-to-event outcomes.
Journal ArticleDOI

A note on a general definition of the coefficient of determination

TL;DR: In this article, a generalization of the coefficient of determination R2 to general regression models is discussed, and a modification of an earlier definition to allow for discrete models is proposed.
Book ChapterDOI

Prognostic/Clinical Prediction Models: Multivariable Prognostic Models: Issues in Developing Models, Evaluating Assumptions and Adequacy, and Measuring and Reducing Errors

TL;DR: An easily interpretable index of predictive discrimination as well as methods for assessing calibration of predicted survival probabilities are discussed, applicable to all regression models, but are particularly needed for binary, ordinal, and time-to-event outcomes.

Tutorial in biostatistics multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors

TL;DR: An easily interpretable index of predictive discrimination as well as methods for assessing calibration of predicted survival probabilities are discussed, which are applicable to all regression models, but are particularly needed for binary, ordinal, and time-to-event outcomes.
Journal ArticleDOI

A simple index of Crohn's-disease activity.

R.F. Harvey, +1 more
- 08 Mar 1980 - 
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