Monoaminergic neuropathology in Alzheimer's disease.
Goran Šimić,Mirjana Babić Leko,Selina Wray,Charles R. Harrington,Ivana Delalle,Nataša Jovanov-Milošević,Danira Bažadona,Luc Buée,Rohan de Silva,Giuseppe Di Giovanni,Claude M. Wischik,Patrick R. Hof +11 more
TLDR
Special emphasis is given to the serotonergic dorsal raphe nucleus (DRN) and noradrenergic LC, among the first to be affected by tau protein abnormalities in the course of sporadic AD, causing behavioral and cognitive symptoms of variable severity.About:
This article is published in Progress in Neurobiology.The article was published on 2017-04-01 and is currently open access. It has received 203 citations till now. The article focuses on the topics: Monoaminergic & Tau protein.read more
Citations
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Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?
TL;DR: The present review highlights the interplays existing between Tau pathology and the innate/adaptive immune responses and indicates an adaptive immune response takes place conjointly during the disease course.
Journal ArticleDOI
Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms
Krista L. Lanctôt,Joan Amatniek,Sonia Ancoli-Israel,Steven E. Arnold,Clive Ballard,Clive Ballard,Jiska Cohen-Mansfield,Zahinoor Ismail,Constantine G. Lyketsos,David Miller,Erik S. Musiek,Ricardo S. Osorio,Paul B. Rosenberg,Andrew Satlin,David C. Steffens,Pierre N. Tariot,Lisa J. Bain,Maria C. Carrillo,James Hendrix,Heidi Jurgens,Brendon P. Boot +20 more
TL;DR: This review will explore the neurobiology of NPSs in AD and specific symptoms common in AD such as psychosis, agitation, apathy, depression, and sleep disturbances.
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A clinicopathological approach to the diagnosis of dementia
Fanny M. Elahi,Bruce L. Miller +1 more
TL;DR: An overview of the salient features of the most common dementia subtypes — Alzheimer disease, vascular dementia, frontotemporal dementia and related syndromes, Lewy body dementias, and prion diseases — with an emphasis on neuropathology, relevant epidemiology, risk factors, and signature signs and symptoms is presented.
Journal ArticleDOI
Locus coeruleus cellular and molecular pathology during the progression of Alzheimer’s disease
Sarah C. Kelly,Bin He,Sylvia E. Perez,Stephen D. Ginsberg,Stephen D. Ginsberg,Elliott J. Mufson,Scott E. Counts +6 more
TL;DR: Observations suggest that noradrenergic LC cellular and molecular pathology is a prominent feature of prodromal disease that contributes to cognitive dysfunction and lend support to a rational basis for targeting LC neuroprotection as a disease modifying strategy.
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Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases
Bao-liang Sun,Li-hua Wang,Tuo Yang,Jing-yi Sun,Leilei Mao,Ming-feng Yang,Hui Yuan,Robert A. Colvin,Xiao-yi Yang +8 more
TL;DR: The clinical importance of ependymal route-based targeted gene therapy and intranasal drug administration in the brain by taking advantage of the unique role played by brain lymphatic pathways in the regulation of CSF flow and ISF/CSF exchange is highlighted.
References
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Journal ArticleDOI
“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more
TL;DR: The workgroup sought to ensure that the revised criteria would be flexible enough to be used by both general healthcare providers without access to neuropsychological testing, advanced imaging, and cerebrospinal fluid measures, and specialized investigators involved in research or in clinical trial studies who would have these tools available.
Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TL;DR: The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.