Nanodrug Delivery: Is the Enhanced Permeability and Retention Effect Sufficient for Curing Cancer?
TLDR
Various barriers for nanosized drug delivery are overviewed with an emphasis on the capillary wall's resistance, the main obstacle to delivering drugs.About:
This article is published in Bioconjugate Chemistry.The article was published on 2016-09-02 and is currently open access. It has received 637 citations till now. The article focuses on the topics: Enhanced permeability and retention effect & Drug delivery.read more
Citations
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The entry of nanoparticles into solid tumours
Shrey Sindhwani,Abdullah Muhammad Syed,Jessica Ngai,Benjamin R. Kingston,Laura Maiorino,Laura Maiorino,Jeremy Rothschild,Presley MacMillan,Yuwei Zhang,Netra Unni Rajesh,Tran Hoang,Jamie L. Y. Wu,Stefan Wilhelm,Anton Zilman,Suresh Gadde,Andrew Sulaiman,Ben Ouyang,Zachary Lin,Lisheng Wang,Mikala Egeblad,Warren C. W. Chan +20 more
TL;DR: The dominant mechanism of nanoparticle entry into solid tumours has now been shown to be an active trans- endothelial pathway rather than the currently established passive transport via inter-endothelial gaps.
Journal ArticleDOI
Rethinking cancer nanotheranostics.
TL;DR: The evolution and state of the art of cancer nanotheranostics is described, with an emphasis on clinical impact and translation, and how diagnosis and therapy are interwoven to solve clinical issues and improve treatment outcomes.
Journal ArticleDOI
Cisplatin: The first metal based anticancer drug.
TL;DR: This article highlights a systematic description on cisplatin which includes a brief history, synthesis, action mechanism, resistance, uses, side effects and modulation of side effects.
Journal ArticleDOI
Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433
Susan Monro,Katsuya L. Colón,Huimin Yin,John Roque,Prathyusha Konda,Shashi Gujar,Randolph P. Thummel,Lothar Lilge,Colin G. Cameron,Sherri A. McFarland,Sherri A. McFarland +10 more
TL;DR: The challenges to bringing PDT into mainstream cancer therapy are summarized, the chemical and photophysical solutions that transition metal complexes offer are considered, and the multidisciplinary effort needed to bring a new drug to clinical trial is put into context.
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Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review
Sarwar Hossen,M. Khalid Hossain,Mohammad Khairul Basher,M.N.H. Mia,Moizur Rahman,M. Jalal Uddin +5 more
TL;DR: In this paper, the authors highlight the recent development of smart drug delivery systems for a number of smart nanocarriers, including liposomes, micelles, dendrimers, meso-porous silica nanoparticles, gold nanoparticles and carbon nanotubes.
References
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Journal ArticleDOI
Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
Dariush Mozaffarian,Emelia J. Benjamin,Alan S. Go,Donna K. Arnett,Michael J. Blaha,Mary Cushman,Sandeep R Das,Sarah D. de Ferranti,Jean-Pierre Després,Heather J. Fullerton,Virginia J. Howard,Mark D. Huffman,Carmen R. Isasi,Monik C. Jiménez,Suzanne E. Judd,Brett M. Kissela,Judith H. Lichtman,Lynda D. Lisabeth,Simin Liu,Rachel H. Mackey,David J. Magid,Darren K. McGuire,Emile R. Mohler,Claudia S. Moy,Paul Muntner,Michael E. Mussolino,Khurram Nasir,Robert W. Neumar,Graham Nichol,Latha Palaniappan,Dilip K. Pandey,Mathew J. Reeves,Carlos J. Rodriguez,Wayne D. Rosamond,Paul D. Sorlie,Joel M. Stein,Amytis Towfighi,Tanya N. Turan,Salim S. Virani,Daniel Woo,Robert W. Yeh,Melanie B. Turner +41 more
TL;DR: Author(s): Writing Group Members; Mozaffarian, Dariush; Benjamin, Emelia J; Go, Alan S; Arnett, Donna K; Blaha, Michael J; Cushman, Mary; Das, Sandeep R; de Ferranti, Sarah; Despres, Jean-Pierre; Fullerton, Heather J; Howard, Virginia J; Huffman, Mark D; Isasi, Carmen R; Jimenez, Monik C; Judd, Suzanne
Journal ArticleDOI
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
TL;DR: Emerging evidence supporting an alternative hypothesis is reviewed—that certain antiangiogenic agents can also transiently “normalize” the abnormal structure and function of tumor vasculature to make it more efficient for oxygen and drug delivery.
Journal ArticleDOI
The extracellular matrix at a glance
TL;DR: The extracellular matrix is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue development.
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