Journal ArticleDOI
Nanogapped Au Antennas for Ultrasensitive Surface-Enhanced Infrared Absorption Spectroscopy
Liangliang Dong,Xiao Yang,Chao Zhang,Benjamin Cerjan,Linan Zhou,Ming Lun Tseng,Yu Zhang,Alessandro Alabastri,Peter Nordlander,Naomi J. Halas +9 more
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TLDR
A new ultrasensitive infrared antenna designed to bring surface-enhanced infrared absorption (SEIRA) spectroscopy into the few-molecule detection range is reported, which offers a new platform for analyzing the IR vibrations of minute quantities of molecules and lends insight into the ultimate limit of single-Molecule SEIRA detection.Abstract:
Surface-enhanced infrared absorption (SEIRA) spectroscopy has outstanding potential in chemical detection as a complement to surface-enhanced Raman spectroscopy (SERS), yet it has historically lagged well behind SERS in detection sensitivity. Here we report a new ultrasensitive infrared antenna designed to bring SEIRA spectroscopy into the few-molecule detection range. Our antenna consists of a bowtie-shaped Au structure with a sub-3 nm gap, positioned to create a cavity above a reflective substrate. This three-dimensional geometry tightly confines incident mid-infrared radiation into its ultrasmall junction, yielding a hot spot with a theoretical SEIRA enhancement factor of more than 107, which can be designed to span the range of frequencies useful for SEIRA. We quantitatively evaluated the IR detection limit of this antenna design using mixed monolayers of 4-nitrothiophenol (4-NTP) and 4-methoxythiolphenol (4-MTP). The optimized antenna structure allows the detection of as few as ∼500 molecules of 4-NT...read more
Citations
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Journal ArticleDOI
Present and Future of Surface-Enhanced Raman Scattering
Judith Langer,Dorleta Jimenez de Aberasturi,Javier Aizpurua,Ramon A. Alvarez-Puebla,Baptiste Auguié,Baptiste Auguié,Jeremy J. Baumberg,Guillermo C. Bazan,Steven E. J. Bell,Anja Boisen,Alexandre G. Brolo,Jaebum Choo,Dana Cialla-May,Dana Cialla-May,Volker Deckert,Volker Deckert,Laura Fabris,Karen Faulds,F. Javier García de Abajo,Royston Goodacre,Duncan Graham,Amanda J. Haes,Christy L. Haynes,Christian W. Huck,Tamitake Itoh,Mikael Käll,Janina Kneipp,Nicholas A. Kotov,Hua Kuang,Eric C. Le Ru,Eric C. Le Ru,Hiang Kwee Lee,Jian-Feng Li,Xing Yi Ling,Stefan A. Maier,Thomas G. Mayerhöfer,Thomas G. Mayerhöfer,Martin Moskovits,Kei Murakoshi,Jwa-Min Nam,Shuming Nie,Yukihiro Ozaki,Isabel Pastoriza-Santos,Jorge Pérez-Juste,Juergen Popp,Juergen Popp,Annemarie Pucci,Stephanie Reich,Bin Ren,George C. Schatz,Timur Shegai,Sebastian Schlücker,Li-Lin Tay,K. George Thomas,Zhong-Qun Tian,Richard P. Van Duyne,Tuan Vo-Dinh,Yue Wang,Katherine A. Willets,Chuanlai Xu,Hongxing Xu,Yikai Xu,Yuko S. Yamamoto,Bing Zhao,Luis M. Liz-Marzán +64 more
TL;DR: Prominent authors from all over the world joined efforts to summarize the current state-of-the-art in understanding and using SERS, as well as to propose what can be expected in the near future, in terms of research, applications, and technological development.
Journal ArticleDOI
Imaging-based molecular barcoding with pixelated dielectric metasurfaces.
Andreas Tittl,Aleksandrs Leitis,Mingkai Liu,Filiz Yesilkoy,Duk-Yong Choi,Dragomir N. Neshev,Yuri S. Kivshar,Hatice Altug +7 more
TL;DR: An imaging-based nanophotonic technique can resolve absorption fingerprints without the need for spectrometry, frequency scanning, or moving mechanical parts, thereby paving the way toward sensitive and versatile miniaturized mid-infrared spectroscopy devices.
Journal ArticleDOI
A review on recent advances in the applications of surface-enhanced Raman scattering in analytical chemistry
TL;DR: This review is focused on recent developments of surface-enhanced Raman scattering (SERS) applications in Analytical Chemistry and covers advances in the fabrication methods of SERS substrates, including nanoparticles immobilization techniques and advanced nanopatterning with metallic features.
Journal ArticleDOI
Angle-multiplexed all-dielectric metasurfaces for broadband molecular fingerprint retrieval
Aleksandrs Leitis,Andreas Tittl,Mingkai Liu,Bang Hyun Lee,Man Bock Gu,Yuri S. Kivshar,Hatice Altug +6 more
TL;DR: This work develops germanium-based high-Q metasurfaces capable of delivering a multitude of spectrally selective and surface-sensitive resonances between 1100 and 1800 cm−1, and uses this approach to detect distinct absorption signatures of different interacting analytes including proteins, aptamers, and polylysine.
Journal ArticleDOI
Advances and applications of nanophotonic biosensors
TL;DR: In this article , the authors provide an overview of the recent developments of label-free nanophotonic biosensors using evanescent-field-based sensing with plasmon resonances in metals and Mie resonance in dielectrics and highlight the prospects of achieving an improved sensor performance and added functionalities by leveraging nanostructures and on-chip and optoelectronic integration, as well as microfluidics, biochemistry and data science toolkits.
References
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Journal ArticleDOI
Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS)
Katrin Kneipp,Katrin Kneipp,Yang Wang,Yang Wang,Harald Kneipp,Harald Kneipp,Lev T. Perelman,Lev T. Perelman,Irving Itzkan,Irving Itzkan,Ramachandra R. Dasari,Ramachandra R. Dasari,Michael S. Feld,Michael S. Feld +13 more
TL;DR: In this article, the first observation of single molecule Raman scattering was made using a single crystal violet molecule in aqueous colloidal silver solution using one second collection time and about $2.
Journal ArticleDOI
Nanoparticles with Raman Spectroscopic Fingerprints for DNA and RNA Detection
TL;DR: Six dissimilar DNA targets with six Raman-labeled nanoparticle probes were distinguished, as well as two RNA targets with single nucleotide polymorphisms, and the current unoptimized detection limit of this method is 20 femtomolar.
Journal ArticleDOI
Shell-isolated nanoparticle-enhanced Raman spectroscopy
Jian-Feng Li,Yi-Fan Huang,Yong（ Georgia Inst Technol Sch Mat Sci Engn） Ding,Zhilin Yang,Song Bo Li,Xiao-Shun Zhou,Fengru Fan,Fengru Fan,Wei Zhang,Zhi-You Zhou,De-Yin Wu,Bin Ren,Zhong Lin（ Georgia Inst Technol Sch Mat Sci Engn） Wang,Zhong-Qun Tian +13 more
TL;DR: Shell-isolated nanoparticle-enhanced Raman spectroscopy is reported, in which the Raman signal amplification is provided by gold nanoparticles with an ultrathin silica or alumina shell, which significantly expands the flexibility of SERS for useful applications in the materials and life sciences, as well as for the inspection of food safety, drugs, explosives and environment pollutants.
Journal ArticleDOI
Resonant optical antennas.
TL;DR: N nanometer-scale gold dipole antennas designed to be resonant at optical frequencies are fabricated, in contradiction to classical antenna theory but in qualitative accordance with computer simulations that take into account the finite metallic conductivity at optical frequency.
Journal ArticleDOI
Ag Nanocrystal Junctions as the Site for Surface-Enhanced Raman Scattering of Single Rhodamine 6G Molecules
TL;DR: In this article, the surface-enhanced Raman scattering (SERS) of single molecules of Rhodamine (R6G) is investigated and it is shown that the SERS signal is significantly higher when the excitation wavelength is resonant with the absorption band of R6G.