Neuropsychological Impairments in Schizophrenia and Psychotic Bipolar Disorder: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Study
S. Kristian Hill,James L. Reilly,Richard S.E. Keefe,James M. Gold,Jeffrey R. Bishop,Elliot S. Gershon,Carol A. Tamminga,Godfrey D. Pearlson,Matcheri S. Keshavan,John A. Sweeney +9 more
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TLDR
Robust cognitive deficits are present and familial in schizophrenia and psychotic bipolar disorder and Severity of cognitive impairments across psychotic disorders was consistent with a continuum model, in which more prominent affective features and less enduring psychosis were associated with less cognitive impairment.Abstract:
ObjectiveFamilial neuropsychological deficits are well established in schizophrenia but remain less well characterized in other psychotic disorders. This study from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium 1) compares cognitive impairment in schizophrenia and bipolar disorder with psychosis, 2) tests a continuum model of cognitive dysfunction in psychotic disorders, 3) reports familiality of cognitive impairments across psychotic disorders, and 4) evaluates cognitive impairment among nonpsychotic relatives with and without cluster A personality traits.MethodParticipants included probands with schizophrenia (N=293), psychotic bipolar disorder (N=227), schizoaffective disorder (manic, N=110; depressed, N=55), their first-degree relatives (N=316, N=259, N=133, and N=64, respectively), and healthy comparison subjects (N=295). All participants completed the Brief Assessment of Cognition in Schizophrenia (BACS) neuropsychological battery.ResultsCognitive impairments among...read more
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Polygenic risk for schizophrenia and measured domains of cognition in individuals with psychosis and controls.
Rebecca Shafee,Rebecca Shafee,Pranav Nanda,Jaya Padmanabhan,Neeraj Tandon,Ney Alliey-Rodriguez,Sreeja Kalapurakkel,Sreeja Kalapurakkel,Daniel J. Weiner,Daniel J. Weiner,Raquel E. Gur,Richard S.E. Keefe,Scot Hill,Jeffrey R. Bishop,Brett A. Clementz,Carol A. Tamminga,Elliot S. Gershon,Godfrey D. Pearlson,Matcheri S. Keshavan,John A. Sweeney,Steven A. McCarroll,Steven A. McCarroll,Elise B. Robinson,Elise B. Robinson +23 more
TL;DR: The effect of polygenetic risk for schizophrenia (PRSSCZ) on measures that differ in their relationships with psychosis onset is compared: a measure of current cognitive abilities that is greatly reduced in psychotic disorder patients, a measures of premorbid intelligence that is minimally affected by psychosis onset, and educational attainment, which covaries with both BACS and WRAT.
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Deconstructing Bipolar Disorder and Schizophrenia: A cross-diagnostic cluster analysis of cognitive phenotypes
Junghee Lee,Junghee Lee,Shemra Rizzo,Lori L. Altshuler,David C. Glahn,David C. Glahn,David J. Miklowitz,Catherine A. Sugar,Jonathan K. Wynn,Jonathan K. Wynn,Michael F. Green,Michael F. Green +11 more
TL;DR: The finding of better social cognitive performance of BD patients than SZ patients in the Lowe cluster suggest that relatively preserved social cognition may be important to identify disease process distinct to each disorder.
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Pharmacogenetic associations of the type-3 metabotropic glutamate receptor (GRM3) gene with working memory and clinical symptom response to antipsychotics in first-episode schizophrenia.
Jeffrey R. Bishop,James L. Reilly,Margret S.H. Harris,Shitalben R. Patel,Rick A. Kittles,Judith A. Badner,Konasale M. Prasad,Vishwajit L. Nimgaonkar,Matcheri S. Keshavan,John A. Sweeney +9 more
TL;DR: Findings suggest important pharmacogenetic relationships between GRM3 variants and changes in cognition and symptom response with exposure to antipsychotics may be useful in identifying patients susceptible to adverse cognitive outcomes associated with antipsychotic treatment.
Journal ArticleDOI
The Brief Assessment of Cognition In Affective Disorders (BAC-A):Performance of patients with bipolar depression and healthy controls
Richard S.E. Keefe,Kolleen H. Fox,Vicki G. Davis,Courtney Kennel,Trina M. Walker,Katherine E. Burdick,Philip D. Harvey +6 more
TL;DR: The BAC-A is sensitive to the cognitive impairments in bipolar disorder patients in traditional neuropsychological domains and in cognitive processes believed to be specifically impaired in affective disorders.
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Sleep endophenotypes of schizophrenia: slow waves and sleep spindles in unaffected first-degree relatives.
Armando D'Agostino,Anna Castelnovo,Simone Cavallotti,Cecilia Casetta,Matteo Marcatili,Orsola Gambini,Maria Paola Canevini,Giulio Tononi,Brady A. Riedner,Fabio Ferrarelli,Simone Sarasso +10 more
TL;DR: Given the slow wave deficits observed in FDRs, it is proposed that disrupted cortical synchronisation increases the risk for SCZ, but thalamic dysfunction is necessary for the disorder to fully develop.
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