Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
Robert J. Motzer,Bernard Escudier,David F. McDermott,Saby George,Hans J. Hammers,Sandhya Srinivas,Scott S. Tykodi,Jeffrey A. Sosman,Giuseppe Procopio,Elizabeth R. Plimack,Daniel Castellano,Toni K. Choueiri,Howard Gurney,Frede Donskov,Petri Bono,John Wagstaff,Thomas Gauler,Takeshi Ueda,Yoshihiko Tomita,Fabio A.B. Schutz,Christian Kollmannsberger,James Larkin,Alain Ravaud,Jason S. Simon,Li-an Xu,Ian M. Waxman,Padmanee Sharma +26 more
TLDR
Overall survival was longer and fewer grade 3 or 4 adverse events occurred with nivolumab than with everolimus among patients with previously treated advanced renal-cell carcinoma.Abstract:
BackgroundNivolumab, a programmed death 1 (PD-1) checkpoint inhibitor, was associated with encouraging overall survival in uncontrolled studies involving previously treated patients with advanced renal-cell carcinoma. This randomized, open-label, phase 3 study compared nivolumab with everolimus in patients with renal-cell carcinoma who had received previous treatment. MethodsA total of 821 patients with advanced clear-cell renal-cell carcinoma for which they had received previous treatment with one or two regimens of antiangiogenic therapy were randomly assigned (in a 1:1 ratio) to receive 3 mg of nivolumab per kilogram of body weight intravenously every 2 weeks or a 10-mg everolimus tablet orally once daily. The primary end point was overall survival. The secondary end points included the objective response rate and safety. ResultsThe median overall survival was 25.0 months (95% confidence interval [CI], 21.8 to not estimable) with nivolumab and 19.6 months (95% CI, 17.6 to 23.1) with everolimus. The haz...read more
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Correlation of genomic alterations assessed by next-generation sequencing (NGS) of tumor tissue DNA and circulating tumor DNA (ctDNA) in metastatic renal cell carcinoma (mRCC): potential clinical implications
Andrew W. Hahn,David Gill,Benjamin L. Maughan,Archana M. Agarwal,Lubina Arjyal,Sumati Gupta,Jessica Streeter,Erin B. Bailey,Sumanta K. Pal,Neeraj Agarwal +9 more
TL;DR: There was discordance in the type of GAs detected suggesting that ctDNA NGS may be more reflective of dynamic tumor genomic heterogeneity, and these two platforms may be considered complementary to each other, rather than interchangeable, for assessment of tumor GAs to guide selection of targeted clinical trial therapies.
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High IDO-1 expression in tumor endothelial cells is associated with response to immunotherapy in metastatic renal cell carcinoma
Andreas Seeber,Gerald Klinglmair,Josef Fritz,Fabian Steinkohl,Kai-Christian Zimmer,Friedrich Aigner,Wolfgang Horninger,Günther Gastl,Bettina Zelger,Andrea Brunner,Renate Pichler +10 more
TL;DR: Investigation for the first time of the predictive role of IDO‐1, a negative immune‐regulatory molecule, on clear cell RCC tissues of 15 patients undergoing nivolumab therapy suggests it may be a more promising predictive biomarker for response to immune‐based cancer therapy in mRCC.
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Nivolumab, anti-programmed death-1 (PD-1) monoclonal antibody immunotherapy: Role in advanced cancers
TL;DR: The clinical trials that have led to the emergence of nivolumab as a treatment option for patients with advanced cancers are outlined and efforts to identify biomarkers of response to nivlumab are ongoing.
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Novel Indications for Bruton’s Tyrosine Kinase Inhibitors, beyond Hematological Malignancies
TL;DR: In addition to the expansion of the role of BTKi monotherapy, combination therapy strategies utilizing ibrutinib with established regimens and combination with modern immunotherapy compounds are being explored.
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Immune Checkpoint Therapies in Prostate Cancer.
TL;DR: The current data on immune checkpoint therapies in prostate cancer and propose future directions are reviewed and patient selection based on clinical attributes and the tumor microenvironment is reviewed.
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