Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
Robert J. Motzer,Bernard Escudier,David F. McDermott,Saby George,Hans J. Hammers,Sandhya Srinivas,Scott S. Tykodi,Jeffrey A. Sosman,Giuseppe Procopio,Elizabeth R. Plimack,Daniel Castellano,Toni K. Choueiri,Howard Gurney,Frede Donskov,Petri Bono,John Wagstaff,Thomas Gauler,Takeshi Ueda,Yoshihiko Tomita,Fabio A.B. Schutz,Christian Kollmannsberger,James Larkin,Alain Ravaud,Jason S. Simon,Li-an Xu,Ian M. Waxman,Padmanee Sharma +26 more
TLDR
Overall survival was longer and fewer grade 3 or 4 adverse events occurred with nivolumab than with everolimus among patients with previously treated advanced renal-cell carcinoma.Abstract:
BackgroundNivolumab, a programmed death 1 (PD-1) checkpoint inhibitor, was associated with encouraging overall survival in uncontrolled studies involving previously treated patients with advanced renal-cell carcinoma. This randomized, open-label, phase 3 study compared nivolumab with everolimus in patients with renal-cell carcinoma who had received previous treatment. MethodsA total of 821 patients with advanced clear-cell renal-cell carcinoma for which they had received previous treatment with one or two regimens of antiangiogenic therapy were randomly assigned (in a 1:1 ratio) to receive 3 mg of nivolumab per kilogram of body weight intravenously every 2 weeks or a 10-mg everolimus tablet orally once daily. The primary end point was overall survival. The secondary end points included the objective response rate and safety. ResultsThe median overall survival was 25.0 months (95% confidence interval [CI], 21.8 to not estimable) with nivolumab and 19.6 months (95% CI, 17.6 to 23.1) with everolimus. The haz...read more
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Immunotherapy in renal cell carcinoma: latest evidence and clinical implications
Matteo Santoni,Francesco Massari,Vincenzo Di Nunno,Alessandro Conti,Alessia Cimadamore,Marina Scarpelli,Rodolfo Montironi,Liang Cheng,Nicola Battelli,Antonio Lopez-Beltran +9 more
Abstract: Advances in understanding the mechanisms of tumour-induced immunosuppression have led to the development of immune-checkpoint inhibitors in cancer patients, including those with renal cell carcinoma (RCC). The optimal combination between immunotherapy and targeted agents (as well as the possible favourable sequential therapy of these two classes of drugs) remains an open question at this moment. Several trials are currently underway to assess the combination of anti-programmed-death 1 (PD-1) or anti-PD-ligand(L)1 agents with other immunotherapies or with anti-vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs). In this editorial, we described the results of the most recent clinical trials on the use of immunotherapies in RCC and the emerging data on the research for reliable biomarkers of tumour response in this setting. In addition, we have focused on the role of the gut microbiome and tumour microenvironment in the development of future therapeutic strategies for RCC patients.
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Clinical Importance of Epstein⁻Barr Virus-Associated Gastric Cancer.
Jun Nishikawa,Hisashi Iizasa,Hironori Yoshiyama,Kanami Shimokuri,Yuki Kobayashi,Sho Sasaki,Munetaka Nakamura,Hideo Yanai,Kohei Sakai,Yutaka Suehiro,Takahiro Yamasaki,Isao Sakaida +11 more
TL;DR: Clinically, EB VaGC has a significantly low frequency of lymph node metastasis compared with EBV-negative gastric cancer, resulting in a better prognosis and novel therapeutic applications for EBVaGC are discussed.
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A comprehensive review of immunotherapies in prostate cancer
TL;DR: All the completed immune therapy trials in prostate cancer are reviewed and important considerations for the next generation of clinical trials are highlighted.
Journal ArticleDOI
An interdisciplinary consensus on the management of bone metastases from renal cell carcinoma
Viktor Grünwald,Berit Eberhardt,Axel Bex,Anne Flörcken,Thomas Gauler,Thorsten Derlin,Martin Panzica,Hans Roland Dürr,Knut Achim Grötz,Rachel H. Giles,Christian von Falck,Anno Graser,Alexander Muacevic,Michael Staehler +13 more
TL;DR: A meeting of experts with a global perspective to perform an unstructured review and elaborate on current treatment strategies on the basis of published data and expertise formulated recommendations for the diagnosis and treatment of patients with RCC and metastasis to the bone.
Journal ArticleDOI
Safety and clinical activity of vascular endothelial growth factor receptor (VEGFR)–tyrosine kinase inhibitors after programmed cell death 1 inhibitor treatment in patients with metastatic clear cell renal cell carcinoma
Rosa Nadal,Asim Amin,Daniel M. Geynisman,Martin H. Voss,Matthew Weinstock,Jaime Doyle,Zhe Zhang,Antonio Viudez,Elizabeth R. Plimack,David F. McDermott,Robert J. Motzer,Brian I. Rini,Hans J. Hammers +12 more
TL;DR: The efficacy and safety of VEGFR-TKIs after PD-1 inhibition were demonstrated in this retrospective study and the response rate was lower and the median progression-free survival was shorter in those patients who received priorPD-1 in combination with VEGfr-TKI.
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TL;DR: Among patients with advanced, previously treated squamous-cell NSCLC, overall survival, response rate, and progression-free survival were significantly better with nivolumab than with docetaxel, regardless of PD-L1 expression level.
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