Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
Robert J. Motzer,Bernard Escudier,David F. McDermott,Saby George,Hans J. Hammers,Sandhya Srinivas,Scott S. Tykodi,Jeffrey A. Sosman,Giuseppe Procopio,Elizabeth R. Plimack,Daniel Castellano,Toni K. Choueiri,Howard Gurney,Frede Donskov,Petri Bono,John Wagstaff,Thomas Gauler,Takeshi Ueda,Yoshihiko Tomita,Fabio A.B. Schutz,Christian Kollmannsberger,James Larkin,Alain Ravaud,Jason S. Simon,Li-an Xu,Ian M. Waxman,Padmanee Sharma +26 more
TLDR
Overall survival was longer and fewer grade 3 or 4 adverse events occurred with nivolumab than with everolimus among patients with previously treated advanced renal-cell carcinoma.Abstract:
BackgroundNivolumab, a programmed death 1 (PD-1) checkpoint inhibitor, was associated with encouraging overall survival in uncontrolled studies involving previously treated patients with advanced renal-cell carcinoma. This randomized, open-label, phase 3 study compared nivolumab with everolimus in patients with renal-cell carcinoma who had received previous treatment. MethodsA total of 821 patients with advanced clear-cell renal-cell carcinoma for which they had received previous treatment with one or two regimens of antiangiogenic therapy were randomly assigned (in a 1:1 ratio) to receive 3 mg of nivolumab per kilogram of body weight intravenously every 2 weeks or a 10-mg everolimus tablet orally once daily. The primary end point was overall survival. The secondary end points included the objective response rate and safety. ResultsThe median overall survival was 25.0 months (95% confidence interval [CI], 21.8 to not estimable) with nivolumab and 19.6 months (95% CI, 17.6 to 23.1) with everolimus. The haz...read more
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Chemokines and cancer: new immune checkpoints for cancer therapy.
TL;DR: It is shown that CXCL10 acts on CD4+ and CD8+ T cells to enhance anti-tumor immunity, and it is suggested that blocking the CCR8-CCL1 interaction, alone or combined with other immune checkpoint inhibitors, as an approach to treat malignant diseases.
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Response to salvage chemotherapy after progression on immune checkpoint inhibitors in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck.
Khalil Saleh,Amaury Daste,Nicolas Martin,Elvire Pons-Tostivint,Anne Auperin,Ruth Gabriela Herrera-Gómez,Neus Baste-Rotllan,François Bidault,Joël Guigay,Christophe Le Tourneau,Esma Saada-Bouzid,Caroline Even +11 more
TL;DR: In R/M SCCHN, the ORR to SCT was high (30%) suggesting that exposure to ICI may increase tumour sensitivity to chemotherapy, and the age at SCT, number of prior chemotherapy regimens, type of chemotherapy before ICI, best response to ICi, site of relapse and Eastern Cooperative Oncology Group at S CT were not associated with response to S CT on univariate analysis.
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Oral mucosal changes induced by anticancer targeted therapies and immune checkpoint inhibitors
TL;DR: This review provides the first available structured data on oral toxicities induced by the new recently FDA- and EMA-approved monoclonal antibodies targeting PD-1, and discusses clinical management of these targeted therapy-related oral changes.
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Augmenting Anticancer Immunity Through Combined Targeting of Angiogenic and PD-1/PD-L1 Pathways: Challenges and Opportunities
TL;DR: The principle mechanisms of VEGF-mediated immunosuppression studied in preclinical models or as part of translational clinical studies are discussed and how these concepts and approaches can be further incorporated into clinical practice to improve immunotherapy outcomes for patients with cancer are discussed.
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Thrombocytopenia in patients with melanoma receiving immune checkpoint inhibitor therapy
Eileen Shiuan,Kathryn E. Beckermann,Alpaslan Özgün,Ciara Marie Kelly,Meredith Ann McKean,Jennifer L. McQuade,Mary Ann Thompson,Igor Puzanov,John P. Greer,Suthee Rapisuwon,Michael A. Postow,Michael A. Postow,Michael A. Davies,Zeynep Eroglu,Douglas B. Johnson +14 more
TL;DR: Thrombocytopenia, especially ITP, induced by immune checkpoint inhibitors appears to be an uncommon irAE that is manageable with observation in mild cases and/or standard ITP treatment algorithms.
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TL;DR: Among patients with advanced, previously treated squamous-cell NSCLC, overall survival, response rate, and progression-free survival were significantly better with nivolumab than with docetaxel, regardless of PD-L1 expression level.
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