Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
Robert J. Motzer,Bernard Escudier,David F. McDermott,Saby George,Hans J. Hammers,Sandhya Srinivas,Scott S. Tykodi,Jeffrey A. Sosman,Giuseppe Procopio,Elizabeth R. Plimack,Daniel Castellano,Toni K. Choueiri,Howard Gurney,Frede Donskov,Petri Bono,John Wagstaff,Thomas Gauler,Takeshi Ueda,Yoshihiko Tomita,Fabio A.B. Schutz,Christian Kollmannsberger,James Larkin,Alain Ravaud,Jason S. Simon,Li-an Xu,Ian M. Waxman,Padmanee Sharma +26 more
TLDR
Overall survival was longer and fewer grade 3 or 4 adverse events occurred with nivolumab than with everolimus among patients with previously treated advanced renal-cell carcinoma.Abstract:
BackgroundNivolumab, a programmed death 1 (PD-1) checkpoint inhibitor, was associated with encouraging overall survival in uncontrolled studies involving previously treated patients with advanced renal-cell carcinoma. This randomized, open-label, phase 3 study compared nivolumab with everolimus in patients with renal-cell carcinoma who had received previous treatment. MethodsA total of 821 patients with advanced clear-cell renal-cell carcinoma for which they had received previous treatment with one or two regimens of antiangiogenic therapy were randomly assigned (in a 1:1 ratio) to receive 3 mg of nivolumab per kilogram of body weight intravenously every 2 weeks or a 10-mg everolimus tablet orally once daily. The primary end point was overall survival. The secondary end points included the objective response rate and safety. ResultsThe median overall survival was 25.0 months (95% confidence interval [CI], 21.8 to not estimable) with nivolumab and 19.6 months (95% CI, 17.6 to 23.1) with everolimus. The haz...read more
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Improved survival after cytoreductive nephrectomy for metastatic renal cell carcinoma in the contemporary immunotherapy era: An analysis of the National Cancer Database.
Nirmish Singla,Ryan Hutchinson,Rashed Ghandour,Yuval Freifeld,Dong Fang,Arthur I. Sagalowsky,Yair Lotan,Aditya Bagrodia,Vitaly Margulis,Hans J. Hammers,Solomon L. Woldu +10 more
TL;DR: Using a large, national, registry-based cohort, the first report of survival outcomes in mRCC patients treated with CN combined with modern IO is provided, supporting an oncologic role for CN in the ICI era and providing preliminary evidence regarding the timing and safety of CN relative to IO administration.
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Hiroki Ishihara,Toshio Takagi,Tsunenori Kondo,Chie Homma,Hidekazu Tachibana,Hironori Fukuda,Kazuhiko Yoshida,Junpei Iizuka,Hirohito Kobayashi,Masayoshi Okumi,Hideki Ishida,Kazunari Tanabe +11 more
TL;DR: A retrospective study revealed a significant association between nivolumab-associated irAEs and prognosis in previously treated mRCC and further prospective studies are necessary to confirm the findings.
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Clinical response to PD-1 blockade correlates with a sub-fraction of peripheral central memory CD4+ T cells in patients with malignant melanoma.
Yoshiko Takeuchi,Atsushi Tanemura,Yasuko Tada,Ichiro Katayama,Atsushi Kumanogoh,Hiroyoshi Nishikawa +5 more
TL;DR: It is proposed that increases in this subset of central memory CD4+ T cells in peripheral blood can be potentially used as a predictor of clinical response to PD-1 blockade therapy in patients with malignant melanoma.
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Programmed Cell Death 1 (PD-1) and Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA-4) in Viral Hepatitis.
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TL;DR: Among patients with advanced, previously treated squamous-cell NSCLC, overall survival, response rate, and progression-free survival were significantly better with nivolumab than with docetaxel, regardless of PD-L1 expression level.
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