Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
Robert J. Motzer,Bernard Escudier,David F. McDermott,Saby George,Hans J. Hammers,Sandhya Srinivas,Scott S. Tykodi,Jeffrey A. Sosman,Giuseppe Procopio,Elizabeth R. Plimack,Daniel Castellano,Toni K. Choueiri,Howard Gurney,Frede Donskov,Petri Bono,John Wagstaff,Thomas Gauler,Takeshi Ueda,Yoshihiko Tomita,Fabio A.B. Schutz,Christian Kollmannsberger,James Larkin,Alain Ravaud,Jason S. Simon,Li-an Xu,Ian M. Waxman,Padmanee Sharma +26 more
TLDR
Overall survival was longer and fewer grade 3 or 4 adverse events occurred with nivolumab than with everolimus among patients with previously treated advanced renal-cell carcinoma.Abstract:
BackgroundNivolumab, a programmed death 1 (PD-1) checkpoint inhibitor, was associated with encouraging overall survival in uncontrolled studies involving previously treated patients with advanced renal-cell carcinoma. This randomized, open-label, phase 3 study compared nivolumab with everolimus in patients with renal-cell carcinoma who had received previous treatment. MethodsA total of 821 patients with advanced clear-cell renal-cell carcinoma for which they had received previous treatment with one or two regimens of antiangiogenic therapy were randomly assigned (in a 1:1 ratio) to receive 3 mg of nivolumab per kilogram of body weight intravenously every 2 weeks or a 10-mg everolimus tablet orally once daily. The primary end point was overall survival. The secondary end points included the objective response rate and safety. ResultsThe median overall survival was 25.0 months (95% confidence interval [CI], 21.8 to not estimable) with nivolumab and 19.6 months (95% CI, 17.6 to 23.1) with everolimus. The haz...read more
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PD-1 and LAG-3 Dominate Checkpoint Receptor–Mediated T-cell Inhibition in Renal Cell Carcinoma
Henning Zelba,Jens Bedke,Jörg Hennenlotter,Sven Mostböck,Markus Zettl,Thomas Zichner,P. Anoop Chandran,Arnulf Stenzl,Hans-Georg Rammensee,Cécile Gouttefangeas +9 more
TL;DR: In vitro analysis of immune checkpoint blockade on intratumoral T cells suggests dual blockade of PD-1 and LAG-3 is a promising checkpoint blockade combination for renal cell carcinoma.
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The Emergence of Precision Urologic Oncology: A Collaborative Review on Biomarker-driven Therapeutics.
TL;DR: The state of the field, current evidence supporting utility of this approach, and gauge potential for the future of biomarker-driven therapeutics in urologic oncology are examined.
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Hyperprogressive Disease in Patients with Non–Small Cell Lung Cancer Treated with Checkpoint Inhibitors: The Role of 18F-FDG PET/CT
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IL17A Blockade Successfully Treated Psoriasiform Dermatologic Toxicity from Immunotherapy.
Daniel H. Johnson,Anisha B. Patel,Marc Uemura,Van Anh Trinh,Natalie Jackson,Chrystia M. Zobniw,Michael T. Tetzlaff,Patrick Hwu,Jonathan L. Curry,Adi Diab +9 more
TL;DR: A case of psoriasiform dermatologic toxicity, induced by inhibition of PD-1 with the mAb pembrolizumab, which resolved after treatment with systemic interleukin IL17A blockade is reported, which suggests a possible pathogenic role of Th17 cells the irAE of the skin in this metastatic melanoma patient.
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