Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
Robert J. Motzer,Bernard Escudier,David F. McDermott,Saby George,Hans J. Hammers,Sandhya Srinivas,Scott S. Tykodi,Jeffrey A. Sosman,Giuseppe Procopio,Elizabeth R. Plimack,Daniel Castellano,Toni K. Choueiri,Howard Gurney,Frede Donskov,Petri Bono,John Wagstaff,Thomas Gauler,Takeshi Ueda,Yoshihiko Tomita,Fabio A.B. Schutz,Christian Kollmannsberger,James Larkin,Alain Ravaud,Jason S. Simon,Li-an Xu,Ian M. Waxman,Padmanee Sharma +26 more
TLDR
Overall survival was longer and fewer grade 3 or 4 adverse events occurred with nivolumab than with everolimus among patients with previously treated advanced renal-cell carcinoma.Abstract:
BackgroundNivolumab, a programmed death 1 (PD-1) checkpoint inhibitor, was associated with encouraging overall survival in uncontrolled studies involving previously treated patients with advanced renal-cell carcinoma. This randomized, open-label, phase 3 study compared nivolumab with everolimus in patients with renal-cell carcinoma who had received previous treatment. MethodsA total of 821 patients with advanced clear-cell renal-cell carcinoma for which they had received previous treatment with one or two regimens of antiangiogenic therapy were randomly assigned (in a 1:1 ratio) to receive 3 mg of nivolumab per kilogram of body weight intravenously every 2 weeks or a 10-mg everolimus tablet orally once daily. The primary end point was overall survival. The secondary end points included the objective response rate and safety. ResultsThe median overall survival was 25.0 months (95% confidence interval [CI], 21.8 to not estimable) with nivolumab and 19.6 months (95% CI, 17.6 to 23.1) with everolimus. The haz...read more
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Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study.
Tomoko Kobayashi,Shintaro Iwama,Yoshinori Yasuda,Norio Okada,Taku Tsunekawa,Takeshi Onoue,Hiroshi Takagi,Daisuke Hagiwara,Yoshihiro Ito,Yoshiaki Morishita,Motomitsu Goto,Hidetaka Suga,Ryoichi Banno,Kenji Yokota,Tetsunari Hase,Masahiro Morise,Naozumi Hashimoto,Masahiko Ando,Hitoshi Kiyoi,Momokazu Gotoh,Yuichi Ando,Masashi Akiyama,Yoshinori Hasegawa,Hiroshi Arima +23 more
TL;DR: The real-world data showed that destructive thyroiditis was an endocrine irAE that was frequently induced by nivolumab and was significantly associated with positive anti-thyroglobulin Abs and/or TPOAbs before treatment.
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Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy
Hengfeng Yuan,Hengfeng Yuan,Wen Jiang,Christina A. von Roemeling,Yaqing Qie,Xiujie Liu,Yuanxin Chen,Yifan Wang,Robert E. Wharen,Kyuson Yun,Guojun Bu,Keith L. Knutson,Betty Y.S. Kim +12 more
TL;DR: Although the initial immune activation mediated by the mBiNE was receptor dependent, the subsequent antitumour immunity also generated protective effects against tumour-cell populations that lacked the HER2 receptor.
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Nivolumab for advanced melanoma: pretreatment prognostic factors and early outcome markers during therapy.
Yoshio Nakamura,Shigehisa Kitano,Akira Takahashi,Arata Tsutsumida,Kenjiro Namikawa,Keiji Tanese,Takayuki Abe,Takeru Funakoshi,Noboru Yamamoto,Masayuki Amagai,Naoya Yamazaki +10 more
TL;DR: Clinical findings of 98 consecutive patients with unresectable stage III or IV melanoma treated with nivolumab between July 2014 and July 2016 are retrospectively analyzed to find early markers associated with OS that might have minimal efficacy in patients with a massive tumor burden.
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Hao-Wen Sim,Jennifer J. Knox +1 more
TL;DR: The clinical evidence for immunotherapy in advanced hepatocellular carcinoma is reviewed, ideas for future drug development are presented, and new therapeutic opportunities are presented.
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Management of patients with recurrent/advanced cervical cancer beyond first line platinum regimens: Where do we stand? A literature review
Stergios Boussios,Esmeralda Seraj,George Zarkavelis,Dimitrios Petrakis,Aristomenes Kollas,Aikaterini Kafantari,Abraam Assi,Konstantina Tatsi,Nicholas Pavlidis,George Pentheroudakis +9 more
TL;DR: Progress in the management of recurrent and advanced cervical cancer patients has been slow and restricted to palliative intent, and patients with locally recurrent and metastatic disease after platinum failure should be considered for clinical trials of novel targeted agents and/or immunotherapy.
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TL;DR: Among patients with advanced, previously treated squamous-cell NSCLC, overall survival, response rate, and progression-free survival were significantly better with nivolumab than with docetaxel, regardless of PD-L1 expression level.
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