Nonalcoholic fatty liver disease a feature of the metabolic syndrome
Giulio Marchesini,Mara Brizi,Giampaolo Bianchi,Sara Tomassetti,Elisabetta Bugianesi,Marco Lenzi,Arthur J. McCullough,S. Natale,Gabriele Forlani,Nazario Melchionda +9 more
TLDR
It is concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity.Abstract:
Insulin sensitivity (euglycemic clamp, insulin infusion rate: 40 mU m(-2) min(-1)) was studied in 30 subjects with biopsy-proven nonalcoholic fatty liver disease (NAFLD), normal glucose tolerance, and a BMI <30 kg/m(2) Of those 30 subjects, 9 had pure fatty liver and 21 had evidence of steatohepatitis In addition, 10 patients with type 2 diabetes under good metabolic control and 10 healthy subjects were studied Most NAFLD patients had central fat accumulation, increased triglycerides and uric acid, and low HDL cholesterol, irrespective of BMI Glucose disposal during the clamp was reduced by nearly 50% in NAFLD patients, as well as in patients with normal body weight, to an extent similar to that of the type 2 diabetic patients Basal free fatty acids were increased, whereas insulin-mediated suppression of lipolysis was less effective (-69% in NAFLD vs -84% in control subjects; P = 0003) Postabsorptive hepatic glucose production (HGP), measured by [6,6-(2)H(2)]glucose, was normal In response to insulin infusion, HGP decreased by only 63% of basal in NAFLD vs 84% in control subjects (P = 0002) Compared with type 2 diabetic patients, NAFLD patients were characterized by lower basal HGP, but with similarly reduced insulin-mediated suppression of HGP There was laboratory evidence of iron overload in many NAFLD patients, but clinical, histological, and biochemical data (including insulin sensitivity) were not correlated with iron status Four subjects were heterozygous for mutation His63Asp of the HFE gene of familiar hemochromatosis We concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity NAFLD may be considered an additional feature of the metabolic syndrome, with specific hepatic insulin resistanceread more
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The Role of Non-Alcoholic Fatty Liver Disease in Cardiovascular Disease
TL;DR: NAFLD is characterized by the early onset of the typical metabolic and vascular pathogenic alterations of atherosclerosis, and the evidence for the association between NAFLD and CVD is weak.
Journal ArticleDOI
Apoptotic markers indicate nonalcoholic steatohepatitis in polycystic ovary syndrome.
Susanne Tan,Lars P. Bechmann,Lars P. Bechmann,Sven Benson,T. Dietz,S. Eichner,Susanne Hahn,Onno E. Janssen,Harald Lahner,Guido Gerken,Klaus Mann,Ali Canbay +11 more
TL;DR: Elevation of apoptotic cell death, its correlation with IR, and a high prevalence of NASH in PCOS patients are demonstrated, indicating PCOS may be a risk factor for progressive hepatic sequelae.
Journal ArticleDOI
Higher fructose intake is inversely associated with risk of nonalcoholic fatty liver disease in older Finnish adults
TL;DR: The cross-sectional results did not support the current hypothesis that high intake of fructose is associated with a higher prevalence of nonalcoholic fatty liver disease as assessed by using the FLI and NAFLD liver fat score.
Journal ArticleDOI
Adipokines and Redox Signaling: Impact on Fatty Liver Disease
Maurizio Parola,Fabio Marra +1 more
TL;DR: A review of recent data suggests a significant role for oxidative stress, reactive oxygen species, and redox signaling in mediating actions of adipokines that are relevant in the pathogenesis of nonalcoholic fatty liver disease, including hepatic insulin resistance, inflammation, and fibrosis.
Journal ArticleDOI
Fatty Liver Index Predicts Further Metabolic Deteriorations in Women with Previous Gestational Diabetes
Latife Bozkurt,Christian S. Göbl,Andrea Tura,Marek Chmelik,Thomas Prikoszovich,Lana Kosi,Oswald Wagner,Michael Roden,Giovanni Pacini,Amalia Gastaldelli,Alexandra Kautzky-Willer +10 more
TL;DR: FL is closely linked to GDM, especially to IR and inflammation, and subjects with the highest FLI values showed significant alterations in FFA kinetics and a higher risk to develop T2DM in future.
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