Nonalcoholic fatty liver disease a feature of the metabolic syndrome
Giulio Marchesini,Mara Brizi,Giampaolo Bianchi,Sara Tomassetti,Elisabetta Bugianesi,Marco Lenzi,Arthur J. McCullough,S. Natale,Gabriele Forlani,Nazario Melchionda +9 more
TLDR
It is concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity.Abstract:
Insulin sensitivity (euglycemic clamp, insulin infusion rate: 40 mU m(-2) min(-1)) was studied in 30 subjects with biopsy-proven nonalcoholic fatty liver disease (NAFLD), normal glucose tolerance, and a BMI <30 kg/m(2) Of those 30 subjects, 9 had pure fatty liver and 21 had evidence of steatohepatitis In addition, 10 patients with type 2 diabetes under good metabolic control and 10 healthy subjects were studied Most NAFLD patients had central fat accumulation, increased triglycerides and uric acid, and low HDL cholesterol, irrespective of BMI Glucose disposal during the clamp was reduced by nearly 50% in NAFLD patients, as well as in patients with normal body weight, to an extent similar to that of the type 2 diabetic patients Basal free fatty acids were increased, whereas insulin-mediated suppression of lipolysis was less effective (-69% in NAFLD vs -84% in control subjects; P = 0003) Postabsorptive hepatic glucose production (HGP), measured by [6,6-(2)H(2)]glucose, was normal In response to insulin infusion, HGP decreased by only 63% of basal in NAFLD vs 84% in control subjects (P = 0002) Compared with type 2 diabetic patients, NAFLD patients were characterized by lower basal HGP, but with similarly reduced insulin-mediated suppression of HGP There was laboratory evidence of iron overload in many NAFLD patients, but clinical, histological, and biochemical data (including insulin sensitivity) were not correlated with iron status Four subjects were heterozygous for mutation His63Asp of the HFE gene of familiar hemochromatosis We concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity NAFLD may be considered an additional feature of the metabolic syndrome, with specific hepatic insulin resistanceread more
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Histological Behavior of Hepatic Steatosis in Morbidly Obese Patients after Weight Loss Induced by Bariatric Surgery
Cláudio Corá Mottin,Myriam Moretto,Alexandre Vontobel Padoin,Carlos Kupski,Aline Maria Swarowsky,Luiz Glock,Vinicius Duval,Jefferson Braga Silva +7 more
TL;DR: Significant improvement in the hepatic histology of steatosis was observed after weight loss induced by bariatric surgery in most patients.
Journal ArticleDOI
Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver disease
Daniel J. Cuthbertson,Fariba Shojaee-Moradie,Victoria S. Sprung,Helen Jones,Christopher J. A. Pugh,Paul G. Richardson,Graham J. Kemp,M. Barrett,Nicola Jackson,E L Thomas,Jimmy D. Bell,A. M. Umpleby +11 more
TL;DR: Although supervised exercise effectively reduced liver fat, improving peripheral IR in NAFLD, the reduction in liver fat was insufficient to improve hepatic IR.
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Association of chronic hepatitis B virus infection with insulin resistance and hepatic steatosis
TL;DR: Investigation of the association of chronic HBV infection with insulin resistance and hepatic steatosis found that chronic viral infections may decrease tissue response to insulin, thereby causing insulin resistance.
Journal ArticleDOI
Serum bilirubin levels are inversely associated with nonalcoholic fatty liver disease
Min-Sun Kwak,Donghee Kim,Goh Eun Chung,Seung Joo Kang,Min Jung Park,Yoon Jun Kim,Jung Hwan Yoon,Hyo-Suk Lee +7 more
TL;DR: This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Efficacy of pitavastatin for the treatment of non-alcoholic steatohepatitis with dyslipidemia: An open-label, pilot study.
Hideyuki Hyogo,Tadashi Ikegami,Katsutoshi Tokushige,Etsuko Hashimoto,Kazuo Inui,Yasushi Matsuzaki,Hironori Tokumo,Fumiaki Hino,Susumu Tazuma +8 more
TL;DR: The aim of the present study was to evaluate the efficacy of probucol for the treatment of NASH with dyslipidemia.
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