Nonalcoholic fatty liver disease a feature of the metabolic syndrome
Giulio Marchesini,Mara Brizi,Giampaolo Bianchi,Sara Tomassetti,Elisabetta Bugianesi,Marco Lenzi,Arthur J. McCullough,S. Natale,Gabriele Forlani,Nazario Melchionda +9 more
TLDR
It is concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity.Abstract:
Insulin sensitivity (euglycemic clamp, insulin infusion rate: 40 mU m(-2) min(-1)) was studied in 30 subjects with biopsy-proven nonalcoholic fatty liver disease (NAFLD), normal glucose tolerance, and a BMI <30 kg/m(2) Of those 30 subjects, 9 had pure fatty liver and 21 had evidence of steatohepatitis In addition, 10 patients with type 2 diabetes under good metabolic control and 10 healthy subjects were studied Most NAFLD patients had central fat accumulation, increased triglycerides and uric acid, and low HDL cholesterol, irrespective of BMI Glucose disposal during the clamp was reduced by nearly 50% in NAFLD patients, as well as in patients with normal body weight, to an extent similar to that of the type 2 diabetic patients Basal free fatty acids were increased, whereas insulin-mediated suppression of lipolysis was less effective (-69% in NAFLD vs -84% in control subjects; P = 0003) Postabsorptive hepatic glucose production (HGP), measured by [6,6-(2)H(2)]glucose, was normal In response to insulin infusion, HGP decreased by only 63% of basal in NAFLD vs 84% in control subjects (P = 0002) Compared with type 2 diabetic patients, NAFLD patients were characterized by lower basal HGP, but with similarly reduced insulin-mediated suppression of HGP There was laboratory evidence of iron overload in many NAFLD patients, but clinical, histological, and biochemical data (including insulin sensitivity) were not correlated with iron status Four subjects were heterozygous for mutation His63Asp of the HFE gene of familiar hemochromatosis We concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity NAFLD may be considered an additional feature of the metabolic syndrome, with specific hepatic insulin resistanceread more
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Evaluation of Polygenic Determinants of Non-Alcoholic Fatty Liver Disease (NAFLD) By a Candidate Genes Resequencing Strategy
Alessia Di Costanzo,Francesca Belardinilli,Diego Bailetti,Marialuisa Sponziello,Laura D'Erasmo,Licia Polimeni,Francesco Baratta,Daniele Pastori,Fabrizio Ceci,Anna Montali,Gabriella Girelli,Bruna De Masi,Antonio Angeloni,Giuseppe Giannini,Maria Del Ben,Francesco Angelico,Marcello Arca +16 more
TL;DR: Overall, TM6SF2, GCKR, PNPLA3 and MBOAT7 were confirmed to be associated with NAFLD and a score based on these genes was highly predictive of this condition, and Interestingly, rs61756425 in PPP1R3B and rs641738 in MBOat7 genes were predictors ofNAFLD severity.
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Validation of the BARD scoring system in Polish patients with nonalcoholic fatty liver disease (NAFLD)
Joanna Raszeja-Wyszomirska,Barbara Szymanik,Małgorzata Ławniczak,Maciej Kajor,Alina Chwist,Piotr Milkiewicz,Marek Hartleb +6 more
TL;DR: The results demonstrate that the BARD scoring system has value in the non-invasive diagnosis of advanced fibrosis in NAFLD patients, and the vast majority of patients withNAFLD would avoid liver biopsy if BARD was broadly introduced into the clinic.
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Curcumin inhibits hyperlipidemia and hepatic fat accumulation in high-fructose-fed male Wistar rats
Nachimuthu Maithilikarpagaselvi,Magadi Gopalakrishna Sridhar,Rathinam Palamalai Swaminathan,Ramalingam Sripradha,Bhawana Ashok Badhe +4 more
TL;DR: Curcumin supplementation significantly lowered TAG content and decreased the protein expression of LXR-α and SREBP1c in the liver and suppressed the expression of lipogenic enzymes, ACLY, ACC, ACC and FAS in rats fed with high-fructose diet.
Journal ArticleDOI
Diabetogenic Impact of Long-Chain ω-3 Fatty Acids on Pancreatic β-Cell Function and the Regulation of Endogenous Glucose Production
TL;DR: Substitution of long-chain ω-3 fatty acids for a small percentage of dietary saturated fat prevents high-saturated fat feeding-induced insulin resistance with respect to peripheral glucose disposal and reverses insulin hypersecretion in response to glucose in vivo.
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Fasting in healthy subjects is associated with intrahepatic accumulation of lipids as assessed by 1H-magnetic resonance spectroscopy
TL;DR: IHL content increases in healthy male subjects during fasting, which demonstrates that nutritional status should be accounted for when assessing IHLs in clinical studies and positively correlated with the concentration of 3-hydroxybutyrate.
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