Nonalcoholic fatty liver disease a feature of the metabolic syndrome
Giulio Marchesini,Mara Brizi,Giampaolo Bianchi,Sara Tomassetti,Elisabetta Bugianesi,Marco Lenzi,Arthur J. McCullough,S. Natale,Gabriele Forlani,Nazario Melchionda +9 more
TLDR
It is concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity.Abstract:
Insulin sensitivity (euglycemic clamp, insulin infusion rate: 40 mU m(-2) min(-1)) was studied in 30 subjects with biopsy-proven nonalcoholic fatty liver disease (NAFLD), normal glucose tolerance, and a BMI <30 kg/m(2) Of those 30 subjects, 9 had pure fatty liver and 21 had evidence of steatohepatitis In addition, 10 patients with type 2 diabetes under good metabolic control and 10 healthy subjects were studied Most NAFLD patients had central fat accumulation, increased triglycerides and uric acid, and low HDL cholesterol, irrespective of BMI Glucose disposal during the clamp was reduced by nearly 50% in NAFLD patients, as well as in patients with normal body weight, to an extent similar to that of the type 2 diabetic patients Basal free fatty acids were increased, whereas insulin-mediated suppression of lipolysis was less effective (-69% in NAFLD vs -84% in control subjects; P = 0003) Postabsorptive hepatic glucose production (HGP), measured by [6,6-(2)H(2)]glucose, was normal In response to insulin infusion, HGP decreased by only 63% of basal in NAFLD vs 84% in control subjects (P = 0002) Compared with type 2 diabetic patients, NAFLD patients were characterized by lower basal HGP, but with similarly reduced insulin-mediated suppression of HGP There was laboratory evidence of iron overload in many NAFLD patients, but clinical, histological, and biochemical data (including insulin sensitivity) were not correlated with iron status Four subjects were heterozygous for mutation His63Asp of the HFE gene of familiar hemochromatosis We concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity NAFLD may be considered an additional feature of the metabolic syndrome, with specific hepatic insulin resistanceread more
Citations
More filters
Journal ArticleDOI
Gender-specific differences in adipose distribution and adipocytokines influence adolescent nonalcoholic fatty liver disease
Oyekoya T. Ayonrinde,John K. Olynyk,Lawrence J. Beilin,Lawrence J. Beilin,Lawrence J. Beilin,Trevor A. Mori,Trevor A. Mori,Craig E. Pennell,Craig E. Pennell,Nicholas de Klerk,Wendy H. Oddy,Peter Shipman,Leon A. Adams,Leon A. Adams,Leon A. Adams +14 more
TL;DR: The male phenotype ofNAFLD is associated with more adverse metabolic features and greater visceral adiposity than the female phenotype despite the lower prevalence of NAFLD, which is related to differences in adipose distribution and adipocytokines.
Journal ArticleDOI
Fatty pancreas, insulin resistance, and β-cell function: a population study using fat-water magnetic resonance imaging.
Vincent Wai-Sun Wong,Grace Lai-Hung Wong,David K.W. Yeung,Jill Abrigo,Alice P.S. Kong,Ruth Chan,Angel Mei-Ling Chim,Jiayun Shen,Chung-Shun Ho,Jean Woo,Winnie C.W. Chu,Henry Lik-Yuen Chan +11 more
TL;DR: 16.1% of this community cohort of adult Hong Kong Chinese volunteers had a fatty pancreas by the definition of the normal range of pancreatic fat, and central obesity, hypertriglyceridemia, and hyperferritinemia are associated with fatty Pancreas.
Journal ArticleDOI
Prevalence of non-alcoholic fatty liver disease in urban south Indians in relation to different grades of glucose intolerance and metabolic syndrome
TL;DR: NAFLD is present in a third of urban Asian Indians and its prevalence increases with increasing severity of glucose intolerance and in MS, the first population-based prevalence of NAFLD from south Asia which faces the brunt of the diabetes epidemic.
Journal ArticleDOI
Insulin resistance and C-reactive protein as independent risk factors for non-alcoholic fatty liver disease in non-obese Asian men.
Seung Ha Park,Byung Ik Kim,Jung Won Yun,Jeong Wook Kim,Dong Il Park,Yong Kyun Cho,In Kyung Sung,Chang Young Park,Chong Il Sohn,Woo Kyu Jeon,Hyang Kim,Eun-Jung Rhee,Won Young Lee,Sun Woo Kim +13 more
TL;DR: The goal of the present study was to examine if insulin resistance and systemic inflammatory markers are independent predictors of NAFLD in non‐obese men.
Journal ArticleDOI
Current concepts in the pathogenesis of nonalcoholic fatty liver disease
TL;DR: A review of the current literature on pathogenesis of NAFLD is presented and recommendations on treatment are scarce and are based mainly on lifestyle changes, including diet and exercise.
References
More filters
Journal ArticleDOI
Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
TL;DR: The correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
Journal ArticleDOI
Role of Insulin Resistance in Human Disease
TL;DR: The possibility is raised that resistance to insulin-stimulated glucose uptake and hyperinsulinemia are involved in the etiology and clinical course of three major related diseases— NIDDM, hypertension, and CAD.
Journal ArticleDOI
Report of the expert committee on the diagnosis and classification of diabetes mellitus
James R. Gavin,K. G M M Alberti,Mayer B. Davidson,Ralph A. DeFronzo,Allan Drash,Steven G. Gabbe,Saul M. Genuth,Maureen I. Harris,Richard Kahn,Harry Keen,William C. Knowler,Harold E. Lebovitz,Noel K. Maclaren,Jerry P. Palmer,Philip Raskin,Robert A. Rizza,Michael P. Stern +16 more
TL;DR: It was deemed essential to develop an appropriate, uniform terminology and a functional, working classification of diabetes that reflects the current knowledge about the disease.
Journal ArticleDOI
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
TL;DR: Methods for the quantification of beta-cell sensitivity to glucose (hyperglycemic clamp technique) and of tissue sensitivity to insulin (euglycemic insulin clamp technique] are described.
Journal ArticleDOI
Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease
TL;DR: In summary, insulin resistance appears to be a syndrome that is associated with a clustering of metabolic disorders, including non-insulin-dependent diabetes mellitus, obesity, hypertension, lipid abnormalities, and atherosclerotic cardiovascular disease.