Nonalcoholic fatty liver disease a feature of the metabolic syndrome
Giulio Marchesini,Mara Brizi,Giampaolo Bianchi,Sara Tomassetti,Elisabetta Bugianesi,Marco Lenzi,Arthur J. McCullough,S. Natale,Gabriele Forlani,Nazario Melchionda +9 more
TLDR
It is concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity.Abstract:
Insulin sensitivity (euglycemic clamp, insulin infusion rate: 40 mU m(-2) min(-1)) was studied in 30 subjects with biopsy-proven nonalcoholic fatty liver disease (NAFLD), normal glucose tolerance, and a BMI <30 kg/m(2) Of those 30 subjects, 9 had pure fatty liver and 21 had evidence of steatohepatitis In addition, 10 patients with type 2 diabetes under good metabolic control and 10 healthy subjects were studied Most NAFLD patients had central fat accumulation, increased triglycerides and uric acid, and low HDL cholesterol, irrespective of BMI Glucose disposal during the clamp was reduced by nearly 50% in NAFLD patients, as well as in patients with normal body weight, to an extent similar to that of the type 2 diabetic patients Basal free fatty acids were increased, whereas insulin-mediated suppression of lipolysis was less effective (-69% in NAFLD vs -84% in control subjects; P = 0003) Postabsorptive hepatic glucose production (HGP), measured by [6,6-(2)H(2)]glucose, was normal In response to insulin infusion, HGP decreased by only 63% of basal in NAFLD vs 84% in control subjects (P = 0002) Compared with type 2 diabetic patients, NAFLD patients were characterized by lower basal HGP, but with similarly reduced insulin-mediated suppression of HGP There was laboratory evidence of iron overload in many NAFLD patients, but clinical, histological, and biochemical data (including insulin sensitivity) were not correlated with iron status Four subjects were heterozygous for mutation His63Asp of the HFE gene of familiar hemochromatosis We concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity NAFLD may be considered an additional feature of the metabolic syndrome, with specific hepatic insulin resistanceread more
Citations
More filters
Journal ArticleDOI
The histologic spectrum of nonalcoholic fatty liver disease
TL;DR: An understanding of the histologic features of NAFLD and the potential pitfalls in the Histologic assessment of this condition is provided.
Journal ArticleDOI
Clinical, anthropometric, biochemical, and histological characteristics of nonobese nonalcoholic fatty liver disease patients of Bangladesh
Shahinul Alam,Utpal Das Gupta,Mahbubul Alam,Jahangir Kabir,Ziaur Rahman Chowdhury,A.K.M. Khorshed Alam +5 more
TL;DR: Nonobese was 25.6 % among NAFLD patients of Bangladesh, and 53.1 % of nonobeseNAFLD cases were NASH, and NASH and fibrosis were similar in the obese andnonobese patients.
Journal ArticleDOI
The Relationship between Normal Serum Uric Acid and Nonalcoholic Fatty Liver Disease
TL;DR: The results suggest that increased SUA concentrations, even within the normal range, are independently associated with the presence of NAFLD.
Journal ArticleDOI
Reproducibility of hepatic fat fraction measurement by magnetic resonance imaging.
Arian Mashhood,Radha Railkar,Takeshi Yokoo,Yakir S Levin,Lisa Clark,Sabrina Fox-Bosetti,Michael S. Middleton,Jonathan K. Riek,Eunkyung Kauh,Bernard J. Dardzinski,Donald E. Williams,Claude B. Sirlin,Norah J. Shire +12 more
TL;DR: To evaluate the reproducibility of magnetic resonance imaging (MRI)‐determined hepatic fat fraction (%) across imaging sites with different magnet types and field strength, MRI‐based methods are used and the results are compared against MR spectroscopy.
Journal ArticleDOI
Weight gain within the normal weight range predicts ultrasonographically detected fatty liver in healthy Korean men
Yoosoo Chang,Seungho Ryu,Eunju Sung,Hee-Yeon Woo,Sung-Il Cho,S. H. Yoo,H. Y. Ahn,Nam Kyong Choi +7 more
TL;DR: Avoiding weight gain per se appears to increase the risk for developing USFL, and avoiding weight gain, even among lean adult individuals, can be helpful in preventing this disease.
References
More filters
Journal ArticleDOI
Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
TL;DR: The correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
Journal ArticleDOI
Role of Insulin Resistance in Human Disease
TL;DR: The possibility is raised that resistance to insulin-stimulated glucose uptake and hyperinsulinemia are involved in the etiology and clinical course of three major related diseases— NIDDM, hypertension, and CAD.
Journal ArticleDOI
Report of the expert committee on the diagnosis and classification of diabetes mellitus
James R. Gavin,K. G M M Alberti,Mayer B. Davidson,Ralph A. DeFronzo,Allan Drash,Steven G. Gabbe,Saul M. Genuth,Maureen I. Harris,Richard Kahn,Harry Keen,William C. Knowler,Harold E. Lebovitz,Noel K. Maclaren,Jerry P. Palmer,Philip Raskin,Robert A. Rizza,Michael P. Stern +16 more
TL;DR: It was deemed essential to develop an appropriate, uniform terminology and a functional, working classification of diabetes that reflects the current knowledge about the disease.
Journal ArticleDOI
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
TL;DR: Methods for the quantification of beta-cell sensitivity to glucose (hyperglycemic clamp technique) and of tissue sensitivity to insulin (euglycemic insulin clamp technique] are described.
Journal ArticleDOI
Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease
TL;DR: In summary, insulin resistance appears to be a syndrome that is associated with a clustering of metabolic disorders, including non-insulin-dependent diabetes mellitus, obesity, hypertension, lipid abnormalities, and atherosclerotic cardiovascular disease.