Nonalcoholic fatty liver disease a feature of the metabolic syndrome
Giulio Marchesini,Mara Brizi,Giampaolo Bianchi,Sara Tomassetti,Elisabetta Bugianesi,Marco Lenzi,Arthur J. McCullough,S. Natale,Gabriele Forlani,Nazario Melchionda +9 more
TLDR
It is concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity.Abstract:
Insulin sensitivity (euglycemic clamp, insulin infusion rate: 40 mU m(-2) min(-1)) was studied in 30 subjects with biopsy-proven nonalcoholic fatty liver disease (NAFLD), normal glucose tolerance, and a BMI <30 kg/m(2) Of those 30 subjects, 9 had pure fatty liver and 21 had evidence of steatohepatitis In addition, 10 patients with type 2 diabetes under good metabolic control and 10 healthy subjects were studied Most NAFLD patients had central fat accumulation, increased triglycerides and uric acid, and low HDL cholesterol, irrespective of BMI Glucose disposal during the clamp was reduced by nearly 50% in NAFLD patients, as well as in patients with normal body weight, to an extent similar to that of the type 2 diabetic patients Basal free fatty acids were increased, whereas insulin-mediated suppression of lipolysis was less effective (-69% in NAFLD vs -84% in control subjects; P = 0003) Postabsorptive hepatic glucose production (HGP), measured by [6,6-(2)H(2)]glucose, was normal In response to insulin infusion, HGP decreased by only 63% of basal in NAFLD vs 84% in control subjects (P = 0002) Compared with type 2 diabetic patients, NAFLD patients were characterized by lower basal HGP, but with similarly reduced insulin-mediated suppression of HGP There was laboratory evidence of iron overload in many NAFLD patients, but clinical, histological, and biochemical data (including insulin sensitivity) were not correlated with iron status Four subjects were heterozygous for mutation His63Asp of the HFE gene of familiar hemochromatosis We concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity NAFLD may be considered an additional feature of the metabolic syndrome, with specific hepatic insulin resistanceread more
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Metformin Prevents and Reverses Inflammation in a Non-Diabetic Mouse Model of Nonalcoholic Steatohepatitis
Yuki Kita,Toshinari Takamura,Hirofumi Misu,Tsuguhito Ota,Seiichiro Kurita,Yumie Takeshita,Masafumi Uno,Naoto Matsuzawa-Nagata,Ken-ichiro Kato,Hitoshi Ando,Akio Fujimura,Koji Hayashi,Toru Kimura,Yinhua Ni,Toshiki Otoda,Ken-ichi Miyamoto,Yoh Zen,Yasuni Nakanuma,Shuichi Kaneko +18 more
TL;DR: Metformin prevented and reversed steatosis and inflammation of NASH in an experimental non-diabetic model without affecting peripheral insulin resistance.
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Nonalcoholic fatty liver disease predicts chronic kidney disease in nonhypertensive and nondiabetic Korean men
Yoosoo Chang,Seungho Ryu,Eunju Sung,Hee-Yeon Woo,Eunock Oh,Kyungsoo Cha,Eunmi Jung,Won Sool Kim +7 more
TL;DR: NAFLD with elevated GGT concentration was associated with an increased CKD risk among nondiabetic, nonhypertensive Korean men, irrespective of metabolic syndrome.
Journal ArticleDOI
Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes?
TL;DR: In conclusion, progressive liver disease and type 2 diabetes are divergent though inter‐related consequences of insulin resistance and the metabolic syndrome.
Journal ArticleDOI
Waist circumference correlates with liver fibrosis in children with non-alcoholic steatohepatitis
Melania Manco,Giorgio Bedogni,Matilde Marcellini,Rita Devito,Paolo Ciampalini,Maria Rita Sartorelli,Donatella Comparcola,Fiorella Piemonte,Valerio Nobili +8 more
TL;DR: In this paper, the authors used multivariable logistic regression models to examine the contribution of waist circumference, high-density lipoprotein (HDL)-cholesterol, triglycerides, blood pressure and glucose to the odds of liver fibrosis as detected by liver biopsy.
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Comparison of purple carrot juice and β-carotene in a high-carbohydrate, high-fat diet-fed rat model of the metabolic syndrome.
TL;DR: In this article, the authors compared the ability of purple carrot juice and β-carotene to reverse structural and functional changes in rats fed a high-carbohydrate, high-fat diet as a model of metabolic syndrome induced by diet.
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