Nonalcoholic fatty liver disease a feature of the metabolic syndrome
Giulio Marchesini,Mara Brizi,Giampaolo Bianchi,Sara Tomassetti,Elisabetta Bugianesi,Marco Lenzi,Arthur J. McCullough,S. Natale,Gabriele Forlani,Nazario Melchionda +9 more
TLDR
It is concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity.Abstract:
Insulin sensitivity (euglycemic clamp, insulin infusion rate: 40 mU m(-2) min(-1)) was studied in 30 subjects with biopsy-proven nonalcoholic fatty liver disease (NAFLD), normal glucose tolerance, and a BMI <30 kg/m(2) Of those 30 subjects, 9 had pure fatty liver and 21 had evidence of steatohepatitis In addition, 10 patients with type 2 diabetes under good metabolic control and 10 healthy subjects were studied Most NAFLD patients had central fat accumulation, increased triglycerides and uric acid, and low HDL cholesterol, irrespective of BMI Glucose disposal during the clamp was reduced by nearly 50% in NAFLD patients, as well as in patients with normal body weight, to an extent similar to that of the type 2 diabetic patients Basal free fatty acids were increased, whereas insulin-mediated suppression of lipolysis was less effective (-69% in NAFLD vs -84% in control subjects; P = 0003) Postabsorptive hepatic glucose production (HGP), measured by [6,6-(2)H(2)]glucose, was normal In response to insulin infusion, HGP decreased by only 63% of basal in NAFLD vs 84% in control subjects (P = 0002) Compared with type 2 diabetic patients, NAFLD patients were characterized by lower basal HGP, but with similarly reduced insulin-mediated suppression of HGP There was laboratory evidence of iron overload in many NAFLD patients, but clinical, histological, and biochemical data (including insulin sensitivity) were not correlated with iron status Four subjects were heterozygous for mutation His63Asp of the HFE gene of familiar hemochromatosis We concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity NAFLD may be considered an additional feature of the metabolic syndrome, with specific hepatic insulin resistanceread more
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Evaluation of the immune response to pneumococcal capsular polysaccharides.
André Scheen,Françoise Luyckx +1 more
TL;DR: Substantial weight loss is accompanied by a marked attenuation of insulin resistance and related metabolic syndrome and, concomitantly, by an important regression of liver steatosis in most patients, although mild inflammation may be detected in some subjects.
Journal ArticleDOI
Short-term strength training reduces gluconeogenesis and NAFLD in obese mice.
Rodrigo Martins Pereira,Kellen Cristina da Cruz Rodrigues,Chadi Pellegrini Anaruma,Marcella Ramos Sant'Ana,Thaís Dantis Pereira de Campos,Rodrigo S. Gaspar,Raphael dos Santos Canciglieri,Diego Gomes de Melo,Rania A. Mekary,Rania A. Mekary,Adelino Sanchez Ramos da Silva,Dennys E. Cintra,Eduardo R. Ropelle,José Rodrigo Pauli,Leandro Pereira de Moura +14 more
TL;DR: There was a reduction of obesity-related hepatic lipogenesis and inflammation after short-term strength training, independent of weight loss, leading to improvements in hepatic insulin sensitivity and glycemic homeostasis in obese mice.
Journal ArticleDOI
3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea attenuates high glucose-induced hepatic lipogenesis in human HepG2 cells through activation of the liver kinase B1 and silent information regulator T1/AMPK-dependent pathway
Yong Pil Hwang,Yong Pil Hwang,Hyung Gyun Kim,Jae Ho Choi,Minh Truong Do,Thu Phuong Tran,Hyo Kon Chun,Young Chul Chung,Tae Cheon Jeong,Hye Gwang Jeong +9 more
TL;DR: Results indicate that CDCQ prevented lipid accumulation by blocking the expression of SREBP-1c and FAS through LKB1/SIRT1 and AMPK activation in HepG2 cells, suggesting thatCDCQ plays a potential role in the prevention of lipogenesis by AM PK activation.
Journal ArticleDOI
Associates of change in liver fat content in the morbidly obese after laparoscopic gastric banding surgery
Madeleine L Phillips,Madeleine L Phillips,S Boase,Sara Wahlroos,Sara Wahlroos,Manish Dugar,Lilian Kow,Jurgen Stahl,John P. Slavotinek,Robin Valentine,James Toouli,James Toouli,Campbell H. Thompson,Campbell H. Thompson +13 more
TL;DR: This study aimed to define the closest associates of change in liver fat content in a population of obese females following laparoscopic gastric banding surgery.
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Nonalcoholic Fatty Liver Disease Markers Are Associated with Insulin Resistance in Type 1 Diabetes
TL;DR: These findings indicate that higher levels of ALT, AST and ALK are additional markers of insulin resistance in type 1 diabetes and suggest that those subjects must be considered as potentially affected not only by a hepatic but also by a multisystemic disease through altered insulin sensitivity.
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