Nonalcoholic fatty liver disease a feature of the metabolic syndrome
Giulio Marchesini,Mara Brizi,Giampaolo Bianchi,Sara Tomassetti,Elisabetta Bugianesi,Marco Lenzi,Arthur J. McCullough,S. Natale,Gabriele Forlani,Nazario Melchionda +9 more
TLDR
It is concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity.Abstract:
Insulin sensitivity (euglycemic clamp, insulin infusion rate: 40 mU m(-2) min(-1)) was studied in 30 subjects with biopsy-proven nonalcoholic fatty liver disease (NAFLD), normal glucose tolerance, and a BMI <30 kg/m(2) Of those 30 subjects, 9 had pure fatty liver and 21 had evidence of steatohepatitis In addition, 10 patients with type 2 diabetes under good metabolic control and 10 healthy subjects were studied Most NAFLD patients had central fat accumulation, increased triglycerides and uric acid, and low HDL cholesterol, irrespective of BMI Glucose disposal during the clamp was reduced by nearly 50% in NAFLD patients, as well as in patients with normal body weight, to an extent similar to that of the type 2 diabetic patients Basal free fatty acids were increased, whereas insulin-mediated suppression of lipolysis was less effective (-69% in NAFLD vs -84% in control subjects; P = 0003) Postabsorptive hepatic glucose production (HGP), measured by [6,6-(2)H(2)]glucose, was normal In response to insulin infusion, HGP decreased by only 63% of basal in NAFLD vs 84% in control subjects (P = 0002) Compared with type 2 diabetic patients, NAFLD patients were characterized by lower basal HGP, but with similarly reduced insulin-mediated suppression of HGP There was laboratory evidence of iron overload in many NAFLD patients, but clinical, histological, and biochemical data (including insulin sensitivity) were not correlated with iron status Four subjects were heterozygous for mutation His63Asp of the HFE gene of familiar hemochromatosis We concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity NAFLD may be considered an additional feature of the metabolic syndrome, with specific hepatic insulin resistanceread more
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Non-alcoholic fatty liver disease: a narrative review of genetics.
TL;DR: The current understanding of the genetics underpinning the development of hepatic steatosis and the progression of NASH is reviewed to transform the strategy to risk-stratify patients with NAFLD and to identify new potential therapeutic targets.
Journal ArticleDOI
Intrahepatic vascular changes in non-alcoholic fatty liver disease: Potential role of insulin-resistance and endothelial dysfunction.
TL;DR: The effects of insulin on the liver microvasculature and the effects of IR on sinusoidal endothelial cells have been studied in animal models of non-alcoholic fatty liver disease and the hypotheses derived and the potential translation of these results into humans are critically discussed.
Journal ArticleDOI
Metabolic syndrome after laparoscopic bariatric surgery.
Clare Nugent,Clare Nugent,Chunhong Bai,Chunhong Bai,Hazem Elariny,Hazem Elariny,Priya Gopalakrishnan,Caitlin Quigley,Michael Garone,Mariam Afendy,Mariam Afendy,Oscar Chan,Angela Wheeler,Angela Wheeler,Arian Afendy,Arian Afendy,Zobair M. Younossi,Zobair M. Younossi +17 more
TL;DR: Patients who underwent malabsorptive bariatric procedures experienced a significantly greater percent excess weight loss than patients who underwent restrictive procedures, and a significant improvement in AST/ALT ratio was noted in those undergoing restrictive surgery.
Journal ArticleDOI
Non-alcoholic fatty liver disease (nafld) - a novel common aspect of the metabolic syndrome
Katerina Bogdanova,Hana Poczatkova,Lenka Uherkova,Dagmar Riegrova,Miroslav Rypka,János Fehér,Giulio Marchesini,Jaroslav Vesely +7 more
TL;DR: There is urgent need in terms of both intensive research pursuits and effective practical measures to deal with this common threat of non-alcoholic fatty liver disease.
Journal ArticleDOI
Effect of traditional Chinese medicine formula Sinisan on chronic restraint stress-induced nonalcoholic fatty liver disease: a rat study.
Fafeng Cheng,Chongyang Ma,Xueqian Wang,Changming Zhai,Guoli Wang,Xiaolin Xu,Jie Mu,Changxiang Li,Zisong Wang,Xiaoyu Zhang,Wenchao Yue,Xin Du,Yajun Lian,Wenxiang Zhu,Xiangjun Yin,Wei Zhen,Wenjie Song,Qingguo Wang +17 more
TL;DR: This study’s results demonstrate that psychological stress may be a significant risk factor of NAFLD and the traditional Chinese medicine formula SNS may have some beneficial effect in antagonizing psychological stress and stress-relatedNAFLD.
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