Optic nerve regeneration screen identifies multiple genes restricting adult neural repair.
Jane A. Lindborg,Nicholas M. Tran,Devon M. Chenette,Kristin DeLuca,Yram Foli,Ramakrishnan Kannan,Yuichi Sekine,Xingxing Wang,Marius Wollan,In-Jung Kim,Joshua R. Sanes,Stephen M. Strittmatter +11 more
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TLDR
In this article, the authors evaluated nearly 400 genes through a large-scale in-vivo regeneration screen and identified dozens of genes that limit axonal regeneration, including interleukin 22 (IL-22) cytokine.About:
This article is published in Cell Reports.The article was published on 2021-03-02 and is currently open access. It has received 24 citations till now. The article focuses on the topics: Regeneration (biology) & Retinal ganglion cell.read more
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Retinal Ganglion Cell Transplantation: Approaches for Overcoming Challenges to Functional Integration
TL;DR: The current state of experimental RGC transplantation is summarized in this paper, and a set of standard approaches to quantifying and reporting experimental outcomes is proposed to guide a collective effort toward functional RGC replacement and optic nerve regeneration.
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The Role of Lipids, Lipid Metabolism and Ectopic Lipid Accumulation in Axon Growth, Regeneration and Repair after CNS Injury and Disease
Debasish Roy,Andrea Tedeschi +1 more
TL;DR: In this article, the role of lipids, lipid metabolism and ectopic lipid accumulation in axon growth, regeneration and spinal cord repair is discussed, and molecular and pharmacological strategies to fine-tune lipid composition and energy metabolism in neurons and non-neuronal cells that can be exploited to improve neurological recovery after CNS trauma and disease.
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Genome-wide chromatin accessibility analyses provide a map for enhancing optic nerve regeneration.
TL;DR: In this paper, the authors identify transcription factors and open chromatin regions that are enriched in rat embryonic RGCs compared to postnatal RGC cells and find that developmental stage-specific gene expression changes correlated with changes in promoter chromatin accessibility.
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Self-renewing macrophages in dorsal root ganglia contribute to promote nerve regeneration.
TL;DR: In this article , the authors mapped the fate and response of dorsal root ganglia (DRG) cells to nerve injury using macrophage depletion, fate-mapping, and single-cell transcriptomics.
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Axon regeneration after optic nerve injury in rats can be improved via PirB knockdown in the retina
Mei Yang,Lan Jian,Wei Fan,Xing Chen,Huan Zou,Yan-Ming Huang,Xiaofan Chen,Yuan-Guo Zhou,Rongdi Yuan +8 more
TL;DR: In this article, the effect of PirB knockdown on the neuroprotection and axonal regeneration of retinal ganglion cells (RGCs) after optic nerve injury in rats was investigated.
References
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Evan Z. Macosko,Evan Z. Macosko,Anindita Basu,Anindita Basu,Rahul Satija,Rahul Satija,James Nemesh,James Nemesh,Karthik Shekhar,Melissa Goldman,Melissa Goldman,Itay Tirosh,Allison R. Bialas,Nolan Kamitaki,Nolan Kamitaki,Emily M. Martersteck,John J. Trombetta,David A. Weitz,Joshua R. Sanes,Alex K. Shalek,Alex K. Shalek,Alex K. Shalek,Aviv Regev,Aviv Regev,Aviv Regev,Steven A. McCarroll,Steven A. McCarroll +26 more
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Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
Spencer Liang,Xiang-Yang Tan,Deborah Luxenberg,Riyez Karim,Kyriaki Dunussi-Joannopoulos,Mary Collins,Lynette A. Fouser +6 more
TL;DR: IL-22 is identified as a new cytokine expressed by Th17 cells that synergizes with IL- 17A or IL-17F to regulate genes associated with skin innate immunity.
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The Pathophysiology and Treatment of Glaucoma: A Review
TL;DR: Primary care physicians can play an important role in the diagnosis of glaucoma by referring patients with positive family history or with suspicious optic nerve head findings for complete ophthalmologic examination and can improve treatment outcomes by reinforcing the importance of medication adherence and persistence.
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Chondroitinase ABC promotes functional recovery after spinal cord injury
Elizabeth J. Bradbury,Lawrence D. F. Moon,Lawrence D. F. Moon,Reena J Popat,V.R. King,GS Bennett,Preena N. Patel,James W. Fawcett,Stephen B. McMahon +8 more
TL;DR: It is demonstrated that CSPGs are important inhibitory molecules in vivo and suggested that their manipulation will be useful for treatment of human spinal injuries.
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Interleukin-22, a T H 17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Yan Zheng,Dimitry M. Danilenko,Patricia Valdez,Ian Kasman,Jeffrey Eastham-Anderson,Jianfeng Wu,Wenjun Ouyang +6 more
TL;DR: The results suggest that TH17 cells, through the production of both IL-22 and IL-17, might have essential functions in host defence and in the pathogenesis of autoimmune diseases such as psoriasis.