Journal ArticleDOI
Overcoming the Incompatibility Challenge in Chemoenzymatic and Multi-Catalytic Cascade Reactions.
TLDR
This Minireview will summarize recent synthetic examples of (chemo)enzymatic cascade reactions and outline promising methods for their spatial control either by using bio-derived or synthetic systems.Abstract:
Multi-catalytic cascade reactions bear a great potential to minimize downstream and purification steps, leading to a drastic reduction of the produced waste. In many examples, the compatibility of chemo- and biocatalytic steps could be easily achieved. Problems associated with the incompatibility of the catalysts and their reactions, however, are very frequent. Cascade-like reactions can hardly occur in this way. One possible solution to combine, in principle, incompatible chemo- and biocatalytic reactions is the defined control of the microenvironment by compartmentalization or scaffolding. Current methods for the control of the microenvironment of biocatalysts go far beyond classical enzyme immobilization and are thus believed to be very promising tools to overcome incompatibility issues and to facilitate the synthetic application of cascade reactions. In this Minireview, we will summarize recent synthetic examples of (chemo)enzymatic cascade reactions and outline promising methods for their spatial control either by using bio-derived or synthetic systems.read more
Citations
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Journal ArticleDOI
A cascade reaction for the synthesis of d-fagomine precursor revisited: Kinetic insight and understanding of the system.
Martina Sudar,Morana Česnik,Pere Clapés,Martina Pohl,Đurđa Vasić-Rački,Zvjezdana Findrik Blažević +5 more
TL;DR: In this paper, aldol adduct (3S,4R)-6-[(benzyloxycarbonyl)amino]-5,6-dideoxyhex-2-ulose, a precursor of the interesting dietary supplement, iminosugar d-fagomine, was studied in a cascade reaction with three enzymes starting from Cbz-N-3-aminopropanol.
Journal ArticleDOI
Chemoenzymatic Cascades Combining Biocatalysis and Transition Metal Catalysis for Asymmetric Synthesis.
TL;DR: In this paper , a minireview is organized based on the action of the metal species (Pd, Ru, Au, Ir, Fe…) in combination with different enzymes, and special attention is paid to the design of sequential processes and concurrent cascades.
Book ChapterDOI
Multi-Enzymatic Cascades In Vitro
TL;DR: The combination of enzymatic reactions in a simultaneous or sequential fashion by designing artificial synthetic cascades allows for the synthesis of complex compounds from simple precursors as mentioned in this paper, which can also lead to a drastic reduction of the produced waste.
OtherDOI
Enzyme Immobilization
TL;DR: In this article , the basic background of the enzyme immobilization process, various factors affecting the immobilization along its applications, and its applications can be a stepping stone for the various industrial sectors as the demand currently is increasing toward more biobased technologies that contribute toward a sustainable present and future.
Journal ArticleDOI
Green One‐Pot Chemo‐Enzymatic Synthesis of a Key Chiral Amine Intermediate: Useful to Pralsetinib Synthesis
Gaikwad Rajendra,Krithika Ganesh,Govinda Rajulu G,Ganesh Sambasivam,Ramaraj Selvaraj,Charan Kumar G,Shashank C Ravikumar,Prajwal C Acharya,Nagashree Shivashankarappa +8 more
TL;DR: In this paper , a facile, chemo-enzymatic one-pot and scalable procedure was developed for the synthesis of the key chiral intermediate of pralsetinib in an aqueous micellar medium.
References
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Dennis E. Discher,Adi Eisenberg +1 more
TL;DR: Future applications of polymer vesicles will rely on exploiting unique property-performance relations, but results to date underscore the fact that biologically derived vesicle are but a small subset of what is physically and chemically possible.
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TL;DR: The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry, and both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements.
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Synthesis of polycaprolactone: a review
Marianne Labet,Wim Thielemans +1 more
TL;DR: This critical review summarises the different conditions which have been described to synthesise PCL, and gives a broad overview of the different catalytic systems that were used (enzymatic, organic and metal catalyst systems).
Journal ArticleDOI
Industrial Methods for the Production of Optically Active Intermediates
Michael Breuer,Klaus Ditrich,Tilo Habicher,Bernhard Hauer,Maria Kesseler,Rainer Stürmer,Thomas Zelinski +6 more
TL;DR: For the industrial implementation of many transformations alternative methods are available and the advantages of the individual methods will be discussed herein and exemplified by syntheses of relevant compounds.
Journal ArticleDOI
Highly permeable polymeric membranes based on the incorporation of the functional water channel protein Aquaporin Z
TL;DR: The approach followed here may lead to more productive and sustainable water treatment membranes, whereas the variable levels of permeability obtained with different concentrations of AqpZ may provide a key property for drug delivery applications.