Journal ArticleDOI
Overcoming the Incompatibility Challenge in Chemoenzymatic and Multi-Catalytic Cascade Reactions.
TLDR
This Minireview will summarize recent synthetic examples of (chemo)enzymatic cascade reactions and outline promising methods for their spatial control either by using bio-derived or synthetic systems.Abstract:
Multi-catalytic cascade reactions bear a great potential to minimize downstream and purification steps, leading to a drastic reduction of the produced waste. In many examples, the compatibility of chemo- and biocatalytic steps could be easily achieved. Problems associated with the incompatibility of the catalysts and their reactions, however, are very frequent. Cascade-like reactions can hardly occur in this way. One possible solution to combine, in principle, incompatible chemo- and biocatalytic reactions is the defined control of the microenvironment by compartmentalization or scaffolding. Current methods for the control of the microenvironment of biocatalysts go far beyond classical enzyme immobilization and are thus believed to be very promising tools to overcome incompatibility issues and to facilitate the synthetic application of cascade reactions. In this Minireview, we will summarize recent synthetic examples of (chemo)enzymatic cascade reactions and outline promising methods for their spatial control either by using bio-derived or synthetic systems.read more
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Journal ArticleDOI
Novel concurrent redox cascades of (R)- and (S)-carvones enables access to carvo-lactones with distinct regio- and enantioselectivity
Naseem Iqbal,Naseem Iqbal,Jon D. Stewart,Peter Macheroux,Florian Rudroff,Marko D. Mihovilovic +5 more
TL;DR: A one-pot enzymatic redox cascade composed of different enoate reductases and various Baeyer-Villiger monooxygenases with complementary regioselectivity that enabled access to six out of eight carvo-lactone stereoisomers starting from readily available natural carvones is investigated.
Journal ArticleDOI
The Synthesis of Chiral γ‐Lactones by Merging Decatungstate Photocatalysis with Biocatalysis
TL;DR: In this paper , a photochemoenzymatic synthesis of aliphatic and aromatic γ-lactones was achieved with up to 99% ee and >99% yield.
Journal ArticleDOI
Nanoreactor with Core–Shell Architectures Used as Spatiotemporal Compartments for “Undisturbed” Tandem Catalysis
TL;DR: In this article, a nanoreactor with bio-inspired compartments made of core-and-shell architectures was proposed to solve the problem of tandem catalysis, where the core and shell architectures allowed the nanoreactors to spatiotemporally separate the tandem catalytic processes from each other.
Journal ArticleDOI
Stereoselective Double Reduction of 3-Methyl-2-cyclohexenone, by Use of Palladium and Platinum Nanoparticles, in Tandem with Alcohol Dehydrogenase
Francesca Coccia,Francesca Coccia,Lucia Tonucci,Piero Del Boccio,Stefano Caporali,Frank Hollmann,Nicola d'Alessandro +6 more
TL;DR: The combination of metal nanoparticles (Pd or Pt NPs) with NAD-dependent thermostable alcohol dehydrogenase (TADH) resulted in the one-flask catalytic double reduction of 3-methyl-2-cyclohexenone to 3-(1S,3S)-methyl cyclohexanol, and the size of the NPs was the critical parameter for the mutual inhibition.
Journal ArticleDOI
Harnessing P450 Enzyme for Biotechnology and Synthetic Biology
Libo Zhang,Libo Zhang,Qian Wang +2 more
TL;DR: Amin et al. as discussed by the authors focus on some recent developments of these strategies which have been used to leverage P450 catalysis, and discuss the remaining challenges and future opportunities for P450 enzymes.
References
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Synthesis of polycaprolactone: a review
Marianne Labet,Wim Thielemans +1 more
TL;DR: This critical review summarises the different conditions which have been described to synthesise PCL, and gives a broad overview of the different catalytic systems that were used (enzymatic, organic and metal catalyst systems).
Journal ArticleDOI
Industrial Methods for the Production of Optically Active Intermediates
Michael Breuer,Klaus Ditrich,Tilo Habicher,Bernhard Hauer,Maria Kesseler,Rainer Stürmer,Thomas Zelinski +6 more
TL;DR: For the industrial implementation of many transformations alternative methods are available and the advantages of the individual methods will be discussed herein and exemplified by syntheses of relevant compounds.
Journal ArticleDOI
Highly permeable polymeric membranes based on the incorporation of the functional water channel protein Aquaporin Z
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