Journal ArticleDOI
Overcoming the Incompatibility Challenge in Chemoenzymatic and Multi-Catalytic Cascade Reactions.
TLDR
This Minireview will summarize recent synthetic examples of (chemo)enzymatic cascade reactions and outline promising methods for their spatial control either by using bio-derived or synthetic systems.Abstract:
Multi-catalytic cascade reactions bear a great potential to minimize downstream and purification steps, leading to a drastic reduction of the produced waste. In many examples, the compatibility of chemo- and biocatalytic steps could be easily achieved. Problems associated with the incompatibility of the catalysts and their reactions, however, are very frequent. Cascade-like reactions can hardly occur in this way. One possible solution to combine, in principle, incompatible chemo- and biocatalytic reactions is the defined control of the microenvironment by compartmentalization or scaffolding. Current methods for the control of the microenvironment of biocatalysts go far beyond classical enzyme immobilization and are thus believed to be very promising tools to overcome incompatibility issues and to facilitate the synthetic application of cascade reactions. In this Minireview, we will summarize recent synthetic examples of (chemo)enzymatic cascade reactions and outline promising methods for their spatial control either by using bio-derived or synthetic systems.read more
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Journal ArticleDOI
Compartmentalization of Multiple Catalysts into Outerand Inner Shells of Hollow Mesoporous Nanospheres for HeterogeneousMulti-Catalyzed/Multi-Component Asymmetric Organocascade
TL;DR: In this article, double-shelled hollow mesoporous nanospheres with isolators were used for heterogenization of multicatalyzed cascade/tandem reactions, which often suffers from the detrimental interactions of incompatible catalysts.
Journal ArticleDOI
Multifunctional Integrated Compartment Systems for Incompatible Cascade Reactions Based on Onion-Like Photonic Spheres.
Kang Zhou,Tian Tian,Chen Wang,Hongwei Zhao,Ning Gao,Hang Yin,Peng Wang,Bart Jan Ravoo,Guangtao Li +8 more
TL;DR: A novel strategy called "iterative etching-grafting" is proposed based on monodispersed photonic spheres (PSs) prepared by microfluidics, which constructs a universal platform for incompatible cascade reactions and shows excellent catalytic performance, convenient monitoring, and efficient substrate selectivity in the deacetalization-Knoevenagel cascade reaction.
Journal ArticleDOI
DESign of Sustainable One-Pot Chemoenzymatic Organic Transformations in Deep Eutectic Solvents for the Synthesis of 1,2- Disubstituted Aromatic Olefins
Nicolás Ríos-Lombardía,María J. Rodríguez-Álvarez,Francisco Morís,Robert Kourist,Natalia Comino,Fernando López-Gallego,Javier González-Sabín,Joaquín García-Álvarez +7 more
TL;DR: The self-assembly of styrene-type olefins into the corresponding stilbenes was conveniently performed in the Deep Eutectic Solvent mixture 1ChCl/2Gly under air and in the absence of hazardous organic co-solvents using a one-pot chemo-biocatalytic route.
Journal ArticleDOI
Biocompatible metal-assisted C–C cross-coupling combined with biocatalytic chiral reductions in a concurrent tandem cascade
Patricia Schaaf,Thomas Bayer,Moumita Koley,Michael Schnürch,Uwe T. Bornscheuer,Florian Rudroff,Marko D. Mihovilovic +6 more
TL;DR: A concurrent chemo/biocatalytic one pot reaction cascade by combining a metal (Pd/Cu) assisted Liebeskind-Srogl (L-S) coupling with an enantioselective enzymatic reduction for the production of chiral amines and alcohols is presented.
Journal ArticleDOI
New reaction pathways by integrating chemo- and biocatalysis
TL;DR: In this paper , the authors highlight recent trends for the combination of enzymes with chemocatalysts and discuss accordingly how integrated catalysis not only delivers benign substitutes for known transformations but moreover enables transformations that would be otherwise impossible.
References
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Synthesis of polycaprolactone: a review
Marianne Labet,Wim Thielemans +1 more
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Journal ArticleDOI
Industrial Methods for the Production of Optically Active Intermediates
Michael Breuer,Klaus Ditrich,Tilo Habicher,Bernhard Hauer,Maria Kesseler,Rainer Stürmer,Thomas Zelinski +6 more
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Journal ArticleDOI
Highly permeable polymeric membranes based on the incorporation of the functional water channel protein Aquaporin Z
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