Journal ArticleDOI
Overcoming the Incompatibility Challenge in Chemoenzymatic and Multi-Catalytic Cascade Reactions.
TLDR
This Minireview will summarize recent synthetic examples of (chemo)enzymatic cascade reactions and outline promising methods for their spatial control either by using bio-derived or synthetic systems.Abstract:
Multi-catalytic cascade reactions bear a great potential to minimize downstream and purification steps, leading to a drastic reduction of the produced waste. In many examples, the compatibility of chemo- and biocatalytic steps could be easily achieved. Problems associated with the incompatibility of the catalysts and their reactions, however, are very frequent. Cascade-like reactions can hardly occur in this way. One possible solution to combine, in principle, incompatible chemo- and biocatalytic reactions is the defined control of the microenvironment by compartmentalization or scaffolding. Current methods for the control of the microenvironment of biocatalysts go far beyond classical enzyme immobilization and are thus believed to be very promising tools to overcome incompatibility issues and to facilitate the synthetic application of cascade reactions. In this Minireview, we will summarize recent synthetic examples of (chemo)enzymatic cascade reactions and outline promising methods for their spatial control either by using bio-derived or synthetic systems.read more
Citations
More filters
Journal ArticleDOI
Developing Bicatalytic Cascade Reactions: Ruthenium-catalyzed Hydrogen Generation From Methanol.
TL;DR: A novel state-of-the-art bi-catalytic system for hydrogen generation from aqueous methanol at low temperature and base concentration is described, where a synergistic effect is observed by applying two molecularly-defined ruthenium complexes A and B3 at the same time under the same conditions.
Journal ArticleDOI
Lipase‐oxovanadium heterogeneous catalysis system: a robust protocol for the dynamic kinetic resolution of sec‐alcohols
TL;DR: In this article, a robust and eco-friendly dynamic kinetic resolution (DKR) protocol for secondary alcohols using a combined heterogeneous catalytic CAL−B/VOSO4 system at 50°C in the relatively green solvent heptane was presented.
Journal ArticleDOI
Multienzymatic Processes Involving Baeyer–Villiger Monooxygenases
TL;DR: BVMOs can be included in cascade reactions, coupled to other redox enzymes such as alcohol dehydrogenases (ADHs) or ene-reductases (EREDs), so that the direct conversion of alcohols or α,βunsaturated carbonylic compounds to the corresponding esters can be achieved.
Journal ArticleDOI
Enzymatic Synthesis of Sialic Acids in Microfluidics to Overcome Cross-Inhibitions and Substrate Supply Limitations.
Franziska Obst,Franziska Obst,Michael Mertz,Philipp J. Mehner,Anthony Beck,Kathrin Castiglione,Andreas Richter,Brigitte Voit,Brigitte Voit,Dietmar Appelhans +9 more
TL;DR: In this article, three enzymes required for the synthesis of the biologically active sialic acid cytidine monophosphate N-acetylneuraminic acid (CMP-Neu5Ac) were immobilized into bulk hydrogels and microstructured hydrogel-enzyme-dot arrays, which were then integrated into microfluidic devices.
Book ChapterDOI
On-pot and cell-free biocatalysis using coimmobilized enzymes on advanced materials.
TL;DR: This chapter summarizes the challenges and opportunities of using immobilized multienzyme systems in step-wise chemical transformations and illustrates how the nature and the physicochemical properties of the materials as well as the engineering of the protein surfaces impact on the overall functionality of immobilized multi- enzyme systems to perform cascade reactions.
References
More filters
Journal Article
Polymer vesicles : Materials science: Soft surfaces
Dennis E. Discher,Adi Eisenberg +1 more
TL;DR: Future applications of polymer vesicles will rely on exploiting unique property-performance relations, but results to date underscore the fact that biologically derived vesicle are but a small subset of what is physically and chemically possible.
Journal ArticleDOI
Polymersomes: tough vesicles made from diblock copolymers.
Bohdana M. Discher,You-Yeon Won,David S. Ege,James C. Lee,Frank S. Bates,Dennis E. Discher,Daniel A. Hammer +6 more
TL;DR: The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry, and both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements.
Journal ArticleDOI
Synthesis of polycaprolactone: a review
Marianne Labet,Wim Thielemans +1 more
TL;DR: This critical review summarises the different conditions which have been described to synthesise PCL, and gives a broad overview of the different catalytic systems that were used (enzymatic, organic and metal catalyst systems).
Journal ArticleDOI
Industrial Methods for the Production of Optically Active Intermediates
Michael Breuer,Klaus Ditrich,Tilo Habicher,Bernhard Hauer,Maria Kesseler,Rainer Stürmer,Thomas Zelinski +6 more
TL;DR: For the industrial implementation of many transformations alternative methods are available and the advantages of the individual methods will be discussed herein and exemplified by syntheses of relevant compounds.
Journal ArticleDOI
Highly permeable polymeric membranes based on the incorporation of the functional water channel protein Aquaporin Z
TL;DR: The approach followed here may lead to more productive and sustainable water treatment membranes, whereas the variable levels of permeability obtained with different concentrations of AqpZ may provide a key property for drug delivery applications.