Journal ArticleDOI
Overcoming the Incompatibility Challenge in Chemoenzymatic and Multi-Catalytic Cascade Reactions.
TLDR
This Minireview will summarize recent synthetic examples of (chemo)enzymatic cascade reactions and outline promising methods for their spatial control either by using bio-derived or synthetic systems.Abstract:
Multi-catalytic cascade reactions bear a great potential to minimize downstream and purification steps, leading to a drastic reduction of the produced waste. In many examples, the compatibility of chemo- and biocatalytic steps could be easily achieved. Problems associated with the incompatibility of the catalysts and their reactions, however, are very frequent. Cascade-like reactions can hardly occur in this way. One possible solution to combine, in principle, incompatible chemo- and biocatalytic reactions is the defined control of the microenvironment by compartmentalization or scaffolding. Current methods for the control of the microenvironment of biocatalysts go far beyond classical enzyme immobilization and are thus believed to be very promising tools to overcome incompatibility issues and to facilitate the synthetic application of cascade reactions. In this Minireview, we will summarize recent synthetic examples of (chemo)enzymatic cascade reactions and outline promising methods for their spatial control either by using bio-derived or synthetic systems.read more
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Strengthening the Combination between Enzymes and Metals in Aqueous Medium: Concurrent Ruthenium‐Catalyzed Nitrile Hydration ‐ Asymmetric Ketone Bioreduction
Elisa Liardo,Rebeca González-Fernández,Nicolás Ríos-Lombardía,Francisco Morís,Joaquín García-Álvarez,Victorio Cadierno,Pascale Crochet,Francisca Rebolledo,Javier González-Sabín +8 more
TL;DR: In this paper, the authors are indebted to the MINECO of Spain (CTQ2013-40591-P and CTQ2016-75986-P) and the Gobierno del Principado de Asturias (Project GRUPIN14-006) for financial support from the European Union's Horizon 2020 MSCAITN-EID program (grant agreement No 634200).
Journal ArticleDOI
Incorporation of Metals and Enzymes with Porous Imine Molecule Cages for Highly Efficient Semiheterogeneous Chemoenzymatic Catalysis
TL;DR: This work fabricated a semiheterogeneous metal–enzyme-integrated catalyst that combines the advantages of homogeneous and heterogeneous catalysis and presents a novel approach to sustainable materials engineering.
Journal ArticleDOI
Artificial Organelles for Energy Regeneration
Lado Otrin,Christin Kleineberg,Lucas Caire da Silva,Katharina Landfester,Ivan Ivanov,MinHui Wang,Claudia Bednarz,Kai Sundmacher,Tanja Vidaković-Koch +8 more
TL;DR: The present contribution provides an overview of the existing ATP regeneration strategies and the related nicotinamide adenine dinucleotide (NAD+) redox cycling, with a focus on compartmentalized systems.
Journal ArticleDOI
Aqueous chemoenzymatic one-pot enantioselective synthesis of tertiary α-aryl cycloketones via Pd-catalyzed C–C formation and enzymatic CC asymmetric hydrogenation
Pengqian Luan,Yunting Liu,Yunting Liu,Yongxing Li,Ran Chen,Chen Huang,Jing Gao,Frank Hollmann,Yanjun Jiang +8 more
TL;DR: An aqueous chemoenzymatic cascade reaction combining Pd-catalyzed C–C formation and enzymatic CC asymmetric hydrogenation was developed for enantioselective synthesis of tertiary α-aryl cycloketones in good yields and excellent enantiOSElectivities.
Journal ArticleDOI
Controlling Catalyst-Phase Selectivity in Complex Mixtures with Amphiphilic Janus Particles.
TL;DR: The synthesis and characterization of Janus silica particles with a hydrophilic silica domain and a silane-modified hydrophobic domain produced via a wax masking technique are reported, showing promising candidates for efficient and phase-selective interfacial catalysis.
References
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