Journal ArticleDOI
Overcoming the Incompatibility Challenge in Chemoenzymatic and Multi-Catalytic Cascade Reactions.
TLDR
This Minireview will summarize recent synthetic examples of (chemo)enzymatic cascade reactions and outline promising methods for their spatial control either by using bio-derived or synthetic systems.Abstract:
Multi-catalytic cascade reactions bear a great potential to minimize downstream and purification steps, leading to a drastic reduction of the produced waste. In many examples, the compatibility of chemo- and biocatalytic steps could be easily achieved. Problems associated with the incompatibility of the catalysts and their reactions, however, are very frequent. Cascade-like reactions can hardly occur in this way. One possible solution to combine, in principle, incompatible chemo- and biocatalytic reactions is the defined control of the microenvironment by compartmentalization or scaffolding. Current methods for the control of the microenvironment of biocatalysts go far beyond classical enzyme immobilization and are thus believed to be very promising tools to overcome incompatibility issues and to facilitate the synthetic application of cascade reactions. In this Minireview, we will summarize recent synthetic examples of (chemo)enzymatic cascade reactions and outline promising methods for their spatial control either by using bio-derived or synthetic systems.read more
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Controlling enzyme reactions by supramolecular protection and deprotection of oligosaccharide substrates.
Milad Zangiabadi,Yan Bao Zhao +1 more
TL;DR: Supramolecular protective receptors that outcompete an enzyme in the binding of oligosaccharides are reported that could be used to control products from the same substrate/enzyme mixture and regulate enzymatic reactions reversibly.
Journal ArticleDOI
Advances in One-Pot Chiral Amine Synthesis Enabled by Amine Transaminase Cascades: Pushing the Boundaries of Complexity
Journal ArticleDOI
Integration of chemo- and bio-catalysis to intensify bioprocesses
TL;DR: Chemoenzymatic cascade reactions (CECRs) as discussed by the authors merge the complementary strengths of chemo-catalysis and bio-calysis, such as the wide reactivity of chemon-catalysts and the exquisite selective properties of biocatalysts, representing an important step toward emulating nature to construct artificial systems for achieving bioprocess intensification.
Journal ArticleDOI
Chemoenzymatic Cascades Combining Biocatalysis and Transition Metal Catalysis for Asymmetric Synthesis
Isabelle Mehawej,Gilles Séraphin +1 more
TL;DR: In this paper , a minireview is organized based on the action of the metal species (Pd, Ru, Au, Ir, Fe…) in combination with different enzymes, and special attention is paid to the design of sequential processes and concurrent cascades.
Journal ArticleDOI
FhuA: From Iron-Transporting Transmembrane Protein to Versatile Scaffolds through Protein Engineering.
TL;DR: FhuA is a natural iron transporter located in the outer membrane of Escherichia coli (E. coli) and has a β-barrel structure composed of 22 antiparallel β-sheets, closed by an internal globular "cork" domain this article .
References
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Journal Article
Polymer vesicles : Materials science: Soft surfaces
Dennis E. Discher,Adi Eisenberg +1 more
TL;DR: Future applications of polymer vesicles will rely on exploiting unique property-performance relations, but results to date underscore the fact that biologically derived vesicle are but a small subset of what is physically and chemically possible.
Journal ArticleDOI
Polymersomes: tough vesicles made from diblock copolymers.
Bohdana M. Discher,You-Yeon Won,David S. Ege,James C. Lee,Frank S. Bates,Dennis E. Discher,Daniel A. Hammer +6 more
TL;DR: The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry, and both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements.
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Synthesis of polycaprolactone: a review
Marianne Labet,Wim Thielemans +1 more
TL;DR: This critical review summarises the different conditions which have been described to synthesise PCL, and gives a broad overview of the different catalytic systems that were used (enzymatic, organic and metal catalyst systems).
Journal ArticleDOI
Industrial Methods for the Production of Optically Active Intermediates
Michael Breuer,Klaus Ditrich,Tilo Habicher,Bernhard Hauer,Maria Kesseler,Rainer Stürmer,Thomas Zelinski +6 more
TL;DR: For the industrial implementation of many transformations alternative methods are available and the advantages of the individual methods will be discussed herein and exemplified by syntheses of relevant compounds.
Journal ArticleDOI
Highly permeable polymeric membranes based on the incorporation of the functional water channel protein Aquaporin Z
TL;DR: The approach followed here may lead to more productive and sustainable water treatment membranes, whereas the variable levels of permeability obtained with different concentrations of AqpZ may provide a key property for drug delivery applications.