Journal ArticleDOI
Overcoming the Incompatibility Challenge in Chemoenzymatic and Multi-Catalytic Cascade Reactions.
TLDR
This Minireview will summarize recent synthetic examples of (chemo)enzymatic cascade reactions and outline promising methods for their spatial control either by using bio-derived or synthetic systems.Abstract:
Multi-catalytic cascade reactions bear a great potential to minimize downstream and purification steps, leading to a drastic reduction of the produced waste. In many examples, the compatibility of chemo- and biocatalytic steps could be easily achieved. Problems associated with the incompatibility of the catalysts and their reactions, however, are very frequent. Cascade-like reactions can hardly occur in this way. One possible solution to combine, in principle, incompatible chemo- and biocatalytic reactions is the defined control of the microenvironment by compartmentalization or scaffolding. Current methods for the control of the microenvironment of biocatalysts go far beyond classical enzyme immobilization and are thus believed to be very promising tools to overcome incompatibility issues and to facilitate the synthetic application of cascade reactions. In this Minireview, we will summarize recent synthetic examples of (chemo)enzymatic cascade reactions and outline promising methods for their spatial control either by using bio-derived or synthetic systems.read more
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Journal ArticleDOI
Opportunities and challenges for combining chemo- and biocatalysis
Florian Rudroff,Marko D. Mihovilovic,Harald Gröger,Radka Snajdrova,Hans Iding,Uwe T. Bornscheuer +5 more
TL;DR: This Review focuses on efforts to combine chemo- and biocatalysts, outlining the opportunities achievable by this approach and also efforts to overcome any incompatibilities between these different systems.
Journal ArticleDOI
Biocatalytic Oxidation Reactions: A Chemist's Perspective
JiaJia Dong,Elena Fernández-Fueyo,Frank Hollmann,Caroline E. Paul,Milja Pesic,Sandy Schmidt,Yonghua Wang,Sabry H. H. Younes,Wuyuan Zhang +8 more
TL;DR: The most important recent developments in the field of biocatalytic oxidation chemistry are critically summarised and the most pressing bottlenecks as well as promising solutions are identified.
Journal ArticleDOI
Photo-Biocatalysis: Biotransformations in the Presence of Light
Luca Schmermund,Valentina Jurkaš,Fatma Feyza Özgen,Giovanni Davide Barone,Hanna C. Büchsenschütz,Christoph K. Winkler,Sandy Schmidt,Robert Kourist,Wolfgang Kroutil +8 more
TL;DR: An overview of the various approaches for using light in biocatalysis is given and enzymes with a light switchable moiety have been investigated to turn off/on or tune the actual reaction.
Journal ArticleDOI
On the taught new tricks of enzymes immobilization: An all-inclusive overview
TL;DR: This review describes the choices of support materials and cross-linkers together with several mechanisms that influence the performance, stabilization and hyperactivation of immobilized enzymes.
References
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Journal ArticleDOI
Dynamic Kinetic Resolution of Primary Alcohols with an Unfunctionalized Stereogenic Center in the β‐Position
TL;DR: In this paper, an enzyme-and metal-catalyzed dynamic kinetic resolution (DKR) was proposed for primary alcohols with an unfunctionalized stereogenic center in the β-position.
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Reaction Design for the Compartmented Combination of Heterogeneous and Enzyme Catalysis
TL;DR: During this study, aimed at the direct synthesis of 2-keto-3-deoxy sugar acids as one intermediate toward biobased building blocks starting from the corresponding sugars by combining heterogeneous inorganic catalysis with enzyme catalysis, several incompatibility problems were overcome.
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Oriented Coimmobilization of Oxidase and Catalase on Tailor-Made Ordered Mesoporous Silica
TL;DR: A uniform pore structural framework was beneficial for enzyme loading, immobilization yield, surface and pore volume filling without hindered adsorption, and catalytic effectiveness of the coimmobilizate and affirm a strategy of optimizing immobilized O2-dependent enzymes via tunable internal structuring of the silica material used as carrier.
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Hybrid Organo- and Biocatalytic Process for the Asymmetric Transformation of Alcohols into Amines in Aqueous Medium
Elisa Liardo,Nicolás Ríos-Lombardía,Francisco Morís,Francisca Rebolledo,Javier González-Sabín +4 more
TL;DR: A hybrid organo- and biocatalytic system for the asymmetric conversion of racemic alcohols into amines was developed and successfully applied to conventional secondary alcohols and sterically hindered β-substituted cycloalkanols.
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A Materials Approach to Site-Isolation of Grubbs Catalysts from Incompatible Solvents and m-Chloroperoxybenzoic Acid
TL;DR: The development of a method for site-isolation of Grubbs second-generation catalyst from MCPBA does not require alteration of structures of the catalysts or reagents, so it may be applied to a wide range of homogeneous catalysts and reagents.