PD-L1 Expression by Two Complementary Diagnostic Assays and mRNA In Situ Hybridization in Small Cell Lung Cancer
Hui Yu,Cory Batenchuk,Andrzej Badzio,Theresa A. Boyle,Piotr Czapiewski,Daniel C. Chan,Xian Lu,Dexiang Gao,Kim Ellison,Ashley Kowalewski,Christopher J. Rivard,Rafal Dziadziuszko,Caicun Zhou,Maen A. Hussein,Donald A. Richards,Sharon Wilks,Marc Monte,William Jeffery Edenfield,Jerome Goldschmidt,Ray D. Page,Brian Ulrich,David M. Waterhouse,Sandra Close,Jacek Jassem,Kimary Kulig,Fred R. Hirsch +25 more
TLDR
A subset of SCLCs is characterized by positive PD‐L1 and/or mRNA expression in tumor cells, and higher PD‐ L1 and mRNA expression correlate with more infiltration of TIICs.About:
This article is published in Journal of Thoracic Oncology.The article was published on 2017-01-01 and is currently open access. It has received 97 citations till now. The article focuses on the topics: Primary tumor & In situ hybridization.read more
Citations
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PD-L1 Immunohistochemistry Comparability Study in Real-Life Clinical Samples: Results of Blueprint Phase 2 Project.
Ming-Sound Tsao,Keith M. Kerr,Mark M. Kockx,Mary Beth Beasley,Alain C. Borczuk,Johan Botling,Lukas Bubendorf,Lucian R. Chirieac,Gang Chen,Teh Ying Chou,Jin Haeng Chung,Sanja Dacic,Sylvie Lantuejoul,Mari Mino-Kenudson,Andre L. Moreira,Andrew G. Nicholson,Masayuki Noguchi,Giuseppe Pelosi,Claudia Poleri,Prudence A. Russell,Jennifer L. Sauter,Erik Thunnissen,Ignacio I. Wistuba,Hui Yu,Murry W. Wynes,Melania Pintilie,Yasushi Yatabe,Fred R. Hirsch +27 more
TL;DR: The Blueprint (BP) Programmed Death Ligand 1 (PD-L1) Immunohistochemistry Comparability Project is a pivotal academic/professional society and industrial collaboration to assess the feasibility of harmonizing the clinical use of five independently developed commercial PD-L 1 immunohistochemical assays.
Journal ArticleDOI
Multiplex digital spatial profiling of proteins and RNA in fixed tissue.
Chris Merritt,Giang T. Ong,Sarah E. Church,Kristi Barker,Patrick Danaher,Gary K. Geiss,Margaret L. Hoang,Jaemyeong Jung,Yan Liang,Jill McKay-Fleisch,Karen Nguyen,Zach Norgaard,Kristina Sorg,Isaac Sprague,Charles Warren,Sarah Warren,Philippa J. Webster,Zoey Zhou,Daniel R. Zollinger,Dwayne Dunaway,Gordon B. Mills,Joseph M. Beechem +21 more
TL;DR: DSP may be used to profile not only proteins and RNAs in biobanked samples but also immune markers in patient samples, with potential prognostic and predictive potential for clinical decision-making.
Journal ArticleDOI
Unravelling the biology of SCLC: implications for therapy
Joshua K. Sabari,Benjamin H. Lok,James Laird,John T. Poirier,Charles M. Rudin,Charles M. Rudin +5 more
TL;DR: Progress made in uncovering aspects of the biology of SCLC and its microenvironment that are defining new therapeutic strategies and offering renewed hope for patients are reviewed.
Journal ArticleDOI
Precision medicine for urothelial bladder cancer: update on tumour genomics and immunotherapy
TL;DR: Several immune checkpoint inhibitors that target programmed cell death protein 1, its ligand PDL1, and cytotoxic T lymphocyte-associated protein 4 (CTLA4) have already been approved for use in bladder cancer, representing the most important change to the urological oncologist's tool-kit in over a decade.
Journal ArticleDOI
A phase Ib study of pembrolizumab plus chemotherapy in patients with advanced cancer (PembroPlus)
Glen J. Weiss,Jordan Waypa,Lisa Blaydorn,Jessica Coats,Kayla McGahey,Ashish Sangal,Jiaxin Niu,Cynthia Lynch,John H. Farley,Vivek Khemka +9 more
TL;DR: Standard dose P can be safely combined with G, G+NP, G+, G+V, I and LD and evaluation to determine if response and duration of response are more robust than what would be expected for chemotherapy or immunotherapy alone requires further validation.
References
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Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
Suzanne L. Topalian,F. Stephen Hodi,Julie R. Brahmer,Scott N. Gettinger,David Smith,David F. McDermott,John D. Powderly,Richard D. Carvajal,Jeffrey A. Sosman,Michael B. Atkins,Philip D. Leming,David R. Spigel,Scott J. Antonia,Leora Horn,Charles G. Drake,Drew M. Pardoll,Lieping Chen,William H. Sharfman,Robert A. Anders,Janis M. Taube,Tracee L. McMiller,Haiying Xu,Alan J. Korman,Maria Jure-Kunkel,Shruti Agrawal,Dan McDonald,Georgia Kollia,Ashok Kumar Gupta,Jon M. Wigginton,Mario Sznol +29 more
TL;DR: Anti-PD-1 antibody produced objective responses in approximately one in four to one in five patients with non-small-cell lung cancer, melanoma, or renal-cell cancer; the adverse-event profile does not appear to preclude its use.
Journal ArticleDOI
Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer
Hossein Borghaei,Luis Paz-Ares,Leora Horn,D. R. Spigel,M. Steins,Neal Ready,L.Q. Chow,Everett E. Vokes,Enriqueta Felip,Esther Holgado,F. Barlesi,M. Kohlhufl,Oscar Arrieta,Marco Angelo Burgio,J. Fayette,H. Lena,Elena Poddubskaya,David E. Gerber,Scott N. Gettinger,Charles M. Rudin,Naiyer A. Rizvi,L. Crina,G. R. Blumenschein,Scott J. Antonia,C. Dorange,C. T. Harbison,F. Graf Finckenstein,Julie R. Brahmer +27 more
TL;DR: Nivolumab was associated with even greater efficacy than docetaxel across all end points in subgroups defined according to prespecified levels of tumor-membrane expression (≥1, ≥5%, and ≥10%) of the PD-1 ligand.
Journal ArticleDOI
Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
Julie R. Brahmer,Karen L. Reckamp,Paul Baas,Lucio Crinò,Wilfried Eberhardt,Elena Poddubskaya,Scott J. Antonia,Adam Pluzanski,Everett E. Vokes,Esther Holgado,David M. Waterhouse,Neal Ready,Justin F. Gainor,Osvaldo Arén Frontera,Libor Havel,Martin Steins,Marina Chiara Garassino,Joachim G.J.V. Aerts,Manuel Domine,Luis Paz-Ares,Martin Reck,Christine Baudelet,Christopher T. Harbison,Brian Lestini,David R. Spigel +24 more
TL;DR: Among patients with advanced, previously treated squamous-cell NSCLC, overall survival, response rate, and progression-free survival were significantly better with nivolumab than with docetaxel, regardless of PD-L1 expression level.
Journal ArticleDOI
Pembrolizumab for the treatment of non-small cell lung cancer
Edward B. Garon,Naiyer A. Rizvi,Rina Hui,Natasha B. Leighl,Ani Sarkis Balmanoukian,Joseph Paul Eder,Amita Patnaik,Charu Aggarwal,Matthew A. Gubens,Leora Horn,Enric Carcereny,Myung-Ju Ahn,Enriqueta Felip,Jong-Seok Lee,Matthew D. Hellmann,Omid Hamid,Jonathan W. Goldman,Jean-Charles Soria,Marisa Dolled-Filhart,Ruth Z. Rutledge,Jin Zhang,Jared Lunceford,Reshma A. Rangwala,Gregory M. Lubiniecki,Charlotte Roach,Kenneth Emancipator,Leena Gandhi +26 more
TL;DR: Pembrolizumab had an acceptable side-effect profile and showed antitumor activity in patients with advanced non-small-cell lung cancer and PD-L1 expression in at least 50% of tumor cells correlated with improved efficacy of pembrolIZumab.
Journal ArticleDOI
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
Roy S. Herbst,Jean-Charles Soria,Marcin Kowanetz,Gregg Fine,Omid Hamid,Michael S. Gordon,J. A. Sosman,David F. McDermott,John D. Powderly,Scott N. Gettinger,Holbrook E Kohrt,Leora Horn,Donald P. Lawrence,Sandra Rost,Maya Leabman,Yuanyuan Xiao,Ahmad Mokatrin,Hartmut Koeppen,Priti S. Hegde,Ira Mellman,Daniel S. Chen,F. Stephen Hodi +21 more
TL;DR: Evaluated data suggest that MPDL3280A is most effective in patients in which pre-existing immunity is suppressed by PD-L1, and is re-invigorated on antibody treatment, as well as across multiple cancer types.
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